Media Centre - IARC NEWS


IARC marks 25th anniversary of EPIC study
17/09/2018 -
About 100 researchers from around the world are gathering at the International Agency for Research on Cancer (IARC) to celebrate the 25th anniversary of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Designed to investigate the relationships of diet, lifestyle, and environmental factors with the incidence of cancer and other chronic diseases, EPIC is one of the largest cohort studies in the world, with more than half a million participants recruited across 10 European countries. To mark the anniversary, IARC is holding a scientific workshop with presentations highlighting results and ongoing projects of EPIC. Topics being discussed include diet, obesity and cancer, biomarkers for early detection, socioeconomic factors and mortality, and air pollution.

More information , Visit the EPIC website
Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018
12/09/2018 -
The International Agency for Research on Cancer (IARC) today released the latest estimates on the global burden of cancer. The GLOBOCAN 2018 database, accessible online as part of the IARC Global Cancer Observatory (GCO), provides estimates of incidence and mortality in 185 countries for 36 types of cancer and for all cancer sites combined. The updated GCO includes nine new cancer sites and several new features, such as predictions until 2040, high-definition graphics that are downloadable in various formats, and two-page fact sheets on populations and major cancer sites.

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Read IARC Press Release 263 , Visit GCO website
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
12/09/2018 -
A new article by researchers from the International Agency for Research on Cancer (IARC) and partners highlights the large geographical diversity in cancer occurrence and the variations in the magnitude and profile of the disease between and within world regions. The analysis, published today in CA: A Cancer Journal for Clinicians, is based on the latest estimates of the global burden of cancer in 2018 and is published in conjunction with the IARC Global Cancer Observatory.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
CA Cancer J Clin, Published online 12 September 2018;
http://dx.doi.org/10.3322/caac.21492

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WHO Classification of Skin Tumours
10/09/2018 -
The WHO Classification of Skin Tumours is the 11th volume in the 4th edition of the WHO series on the classification of human tumours. These authoritative and concise reference books provide an international standard for anyone involved in cancer research or the care of cancer patients.

WHO Classification of Skin Tumours
WHO Classification of Tumours, 4th Edition, Volume 11
Edited by Elder DE, Massi D, Scolyer RA, Willemze R

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IARC publication highly commended by the British Medical Association
05/09/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce that WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, revised 4th edition, has been highly commended in the Pathology category of the 2018 British Medical Association (BMA) Medical Book Awards. This authoritative, concise reference book provides an international standard for oncologists and pathologists and serves as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

Watch video , See the BMA Medical Book Awards
Professor Supannee Promthet (11 September 1957 – 29 August 2018)
03/09/2018 -
The International Agency for Research on Cancer (IARC) is deeply saddened by the passing of Professor Supannee Promthet (formerly Sriamporn), a longstanding friend and collaborator of the Agency, who died Wednesday 29 August 2018. Our deepest sympathy goes to her family.

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Traditional and commercial alcohols and esophageal cancer risk in Kenya
22/08/2018 -
A new study by scientists from the International Agency for Research on Cancer (IARC) and partners investigates the role of commercial and locally manufactured alcohols in oesophageal cancer in Kenya. The study, published in the International Journal of Cancer, finds that alcohol consumption is a large contributor to the oesophageal cancer burden, particularly in men, even after adjusting for tobacco use. Consumption of the traditional spirit chang'aa is associated with a particularly strong increased risk of oesophageal cancer.

Menya D, Kigen N, Oduor M, Maina SK, Some F, Chumba D, et al.
Traditional and commercial alcohols and esophageal cancer risk in Kenya
Int J Cancer, Published online 17 August 2018;
https://doi.org/10.1002/ijc.31804

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Cancer incidence and mortality patterns in Europe
14/08/2018 -
A new study led by the International Agency for Research on Cancer (IARC), in collaboration with the European Network of Cancer Registries (ENCR) and the European Commission’s Joint Research Centre (JRC), estimates 3.9 million new cases of cancer (excluding non-melanoma skin cancer) and 1.9 million deaths from cancer in Europe in 2018. The report, published in the European Journal of Cancer, describes the estimated incidence and mortality burden from 25 common cancers in 40 European countries, in the European Union’s 28 Member States, and in Europe, for 2018.

Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al.
Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018
Eur J Cancer. Published online 9 August 2018;
https://dx.doi.org/10.1016/j.ejca.2018.07.005

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IARC Monographs Meetings - Volume 124: Shift Work That Involves Circadian Disruption
14/08/2018 -
IARC Monographs Volume 124: Shift Work That Involves Circadian Disruption
4–11 June 2019
Lyon, France

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Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010
09/08/2018 -
New data from the Automated Childhood Cancer Information System (ACCIS), a project coordinated by the International Agency for Research on Cancer (IARC), reveal a continued increase in the incidence rates of cancer in children and adolescents across Europe during the period 1991–2010. The results, published in The Lancet Oncology, show an average annual increase of 0.5% in children (age 0–14 years) and of 1.0% in adolescents (age 15–19 years). The study includes data on more than 180 000 cases arising in 1.3 billion person-years, which were contributed by 53 population-based cancer registries in 19 countries.

Steliarova-Foucher E, Fidler MM, Colombet M, Lacour B, Kaatsch P, Piñeros M, et al., on behalf of the ACCIS contributors
Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study
Lancet Oncol. Published online 8 August 2018;
https://dx.doi.org/10.1016/S1470-2045(18)30423-6

Listen to podcast on ACCIS

Read the article , Visit the ACCIS website
IARC Monographs Volume 118: Welding, Molybdenum Trioxide, and Indium Tin Oxide
30/07/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on "Welding, Molybdenum Trioxide, and Indium Tin Oxide" is now available online. This volume comprises three Monographs: welding, molybdenum trioxide, and indium tin oxide.

Visit the Volume 118 webpage
IARC Postdoctoral Opportunities - Section/Group: Section of Genetics / Genetic Epidemiology Group
18/07/2018 -
A postdoctoral opportunity is immediately available within the Genetic Epidemiology Group to contribute in one of their multidisciplinary cancer studies. These include the recent Cancer Research UK Grand Challenge project ‘Mutographs’, which aims to identify mutation signatures for 5 different cancers, as well as large scale genome-wide and Mendelian randomization studies.

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First global estimate of breast cancer incidence in women living with HIV
16/07/2018 -
A new study by researchers from the International Agency for Research on Cancer (IARC) estimates for the first time the global and regional burden of breast cancer among women living with HIV. The study, published in the International Journal of Cancer, combined GLOBOCAN estimates of age-specific breast cancer incidence for each country with the corresponding UNAIDS estimates of HIV prevalence. The results showed that in 2012, more than 6000 women with HIV, most of them premenopausal women living in sub-Saharan Africa, were diagnosed with breast cancer. With an increase in breast cancer incidence expected during the next decade, early detection efforts and research into treatments for this specific population are needed.

McCormack V, Febvey-Combes O, Ginsburg O, Dos-Santos-Silva I
Breast cancer in women living with HIV: a first global estimate
Int J Cancer, Published online 11 July 2018;
https://dx.doi.org/10.1002/ijc.31722

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Prediction of acute myeloid leukaemia risk in healthy individuals
13/07/2018 -
As part of a new study by scientists from the International Agency for Research on Cancer (IARC) and partners, published in Nature, researchers performed deep sequencing of DNA from individuals who later developed acute myeloid leukaemia (AML) and individuals who did not. The results, based on the large European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, showed that individuals who later developed AML had more genetic mutations per sample, higher variant allele frequencies (indicating greater clonal expansion), and enrichment of mutations in specific genes. In the future, these findings could enable earlier detection and monitoring and may help to inform intervention.

Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al.
Prediction of acute myeloid leukaemia risk in healthy individuals
Nature, Published online 9 July 2018;
https://dx.doi.org/10.1038/s41586-018-0317-6

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Blood test can help identify the target population to screen for lung cancer
12/07/2018 -
A new study by researchers from the International Agency for Research on Cancer (IARC), published today in JAMA Oncology, demonstrates that a blood test measuring four protein biomarkers can improve the identification of individuals who would later develop lung cancer. These biomarkers may help refine the criteria for including current and former smokers in lung cancer screening programmes, using low-dose computed tomography (CT) scans, aimed at reducing deaths from this common cancer.

Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer
Assessment of lung cancer risk on the basis of a biomarker panel of circulating proteins
JAMA Oncol. Published online 12 July 2018;
http://dx.doi.org/10.1001/jamaoncol.2018.2078

Read article , IARC Press Release 262
IARC Postdoctoral Opportunities - Section/Group: Section of Early Detection and Prevention/Prevention and Implementation Group
11/07/2018 -
A postdoctoral opportunity is immediately available for an epidemiologist/medical statistician at the Prevention and Implementation (PRI) Group. PRI coordinates large international studies to evaluate new primary and secondary cancer preventive strategies, with emphasis on the use of new technologies, including molecular markers.
Deadline: 15 August 2018

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Reducing social inequalities in cancer: setting priorities for research
10/07/2018 -
The International Agency for Research on Cancer (IARC) convened a Working Group of 36 international multidisciplinary experts in April 2018 to review the latest research and evidence about social inequalities and cancer. A Commentary, published today in CA: A Cancer Journal for Clinicians, provides a summary of the topics addressed by the Working Group. The Commentary highlights IARC's commitment as the cancer agency of the World Health Organization (WHO) in light of the focus on universal health coverage and the Sustainable Development Goals. Three priority areas to reduce social inequalities in cancer were identified: generating knowledge and monitoring progress on cancer inequalities globally, expanding research on prevention, and focusing on reducing inequalities when implementing cancer control measures. The full scientific report will be published later this year.

Vaccarella S, Lortet-Tieulent J, Saracci R, Fidler MM, Conway DI, Vilahur N, et al.
Reducing social inequalities in cancer: setting priorities for research
CA Cancer J Clin, Published online 10 July 2018;
http://dx.doi.org/10.3322/caac.21463

Read the Commentary
IARC Monographs evaluation of the carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates
29/06/2018 -
The results of the recent IARC Monographs evaluation of the carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates (methyl acrylate, ethyl acrylate, 2-ethylhexyl acrylate, and trimethylolpropane triacrylate) have now been published in The Lancet Oncology. This summary article presents the conclusions of the IARC Monographs Meeting 122. The evaluations for methyl acrylate and ethyl acrylate and for 2-ethylhexyl acrylate were updated since these agents were considered previously in 1999 and 1994, respectively. Isobutyl nitrite, β-picoline, and trimethylolpropane triacrylate were evaluated by the Working Group for the first time.
The full scientific assessment will be published as Volume 122 of the IARC Monographs.

IARC Monographs Vol. 122 Group
Lancet Oncol, Published online 28 June 2018;
http://dx.doi.org/10.1016/S1470-2045(18)30491-1

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New data on cancer cases in France attributable to lifestyle and environmental factors: the four major risk factors are tobacco use, alcohol consumption, an unbalanced diet, and overweight
25/06/2018 -
The International Agency for Research on Cancer (IARC) is today publishing a full report on the proportion of new cancer cases in adults in Metropolitan France in 2015 that are associated with 13 major lifestyle and environmental risk factors. The study is the result of a close collaboration with French health agencies and many international experts. The report is available on the Global Cancer Observatory (GCO) website.

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Read IARC Press Release 261 [in French] , Visit GCO website
IARC Monographs Volume 116: Drinking Coffee, Mate, and Very Hot Beverages
13/06/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on “Drinking Coffee, Mate, and Very Hot Beverages” is now available online. This volume comprises two Monographs: Drinking coffee, and Drinking mate and very hot beverages.

Visit the Volume 116 webpage
Launch of IARC Regional Hub for Cancer Registration in the Caribbean
12/06/2018 -
The International Agency for Research on Cancer (IARC) and its partners are launching a new Regional Hub for Cancer Registration in the Caribbean. The IARC Caribbean Cancer Registry Hub will provide technical training workshops, assessments of cancer registry operations in four countries, statistical analysis of cancer registry data for two registries, and development of a standard operations manual for registries. The project is a partnership between IARC, the Caribbean Public Health Agency (CARPHA), the United States Centers for Disease Control and Prevention (CDC), the United States National Cancer Institute (NCI) of the National Institutes of Health (NIH), and the North American Association of Central Cancer Registries (NAACCR).

Visit the GICR website
Professor Bernard Stewart appointed a Member of the Order of Australia
11/06/2018 -
The International Agency for Research on Cancer (IARC) wishes to congratulate Professor Bernard William Stewart, who has been honoured in the Queen’s Birthday Honours List by being appointed a Member of the Order of Australia “for significant service to medicine in the field of environmental carcinogenesis, as a researcher and advocate, and to professional medical organisations”. Professor Stewart was co-editor of IARC’s World Cancer Report in 2003 and 2014; he is also co-editor, with Dr Christopher Wild and Dr Elisabete Weiderpass, of the next World Cancer Report, scheduled to appear in May 2019.

Visit the World Cancer Report webpage
IARC Monographs Meeting: Advisory Group to Recommend Priorities for IARC Monographs during 2020-2024
08/06/2018 -
Advisory Group to Recommend Priorities for IARC Monographs during 2020-2024
25-27 March 2019
Lyon, France

Call for Nominations of Agents (closing date 23 December 2018)
WHO Declaration of Interests for this meeting

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New IARC/GICR Collaborating Centre established to improve cancer registration in Asia
28/05/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce the signature of a new Memorandum of Understanding with the National Cancer Center of the Republic of Korea, to increase support for cancer registration in Asia. The Global Initiative for Cancer Registry Development (GICR), which is led by IARC, is an international partnership that combines technical support, training, and advocacy to ensure that cancer registry systems are developed across the world to inform national cancer control.

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IARC Handbooks meeting: Advisory Group to Recommend an Update to the Working Procedures (11–13 February 2019)
24/05/2018 -
In 2019, IARC will amend the Working Procedures of the IARC Handbooks of Cancer Prevention. The Working Procedures describe the principles and procedures used in developing IARC Handbooks, including the scientific criteria that guide the evaluations. The objective is to convene an international group of experts to reflect on the scientific developments and procedural changes that have occurred in the fields of primary and secondary prevention, and to establish strong guidance for future IARC Handbooks.

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Effectiveness of HPV vaccination against high grade cervical lesions in Japan
18/05/2018 -
A new study, initiated in 2016 by the International Agency for Research on Cancer (IARC), describes the increasing incidence rates of cervical cancer and the low uptake of human papillomavirus (HPV) vaccination among Japanese women. The study, published in the journal Vaccine, reports the effectiveness of HPV vaccine against the development of high-grade cervical lesions and is based on Japanese population-based cancer screening data.

Konno R, Konishi H, Sauvaget C, Ohashi Y, Kakizoe T
Effectiveness of HPV vaccination against high grade cervical lesions in Japan
Vaccine. Published online 16 May 2018;
http://dx.doi.org/10.1016/j.vaccine.2018.05.048

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IARC Governing Council elects new IARC Director
17/05/2018 -
The International Agency for Research on Cancer (IARC) Governing Council, today elected Dr Elisabete Weiderpass as the new Director of the Agency. Dr Weiderpass will take office on 1 January 2019. IARC Directors are elected for a five-year term and are eligible for one further five-year term.

Read IARC Press Release 260 , View photos
New evidence on link between obesity and smoking behaviour from genetic data: obese people at higher risk of smoking
17/05/2018 -
A study by the International Agency for Research on Cancer (IARC) provides new evidence that increased weight and obesity may result in increased smoking. The study, published in the British Medical Journal (BMJ), found that increased body mass index (BMI), body fat percentage, and waist circumference were associated both with a higher risk of being a smoker and with greater smoking intensity.

Carreras-Torres R, Johansson M, Haycock PC, Relton CL, Smith GD, Brennan P, et al.
Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank
BMJ. Published online 16 May 2018; https://doi.org/10.1136/bmj.k1767

Read article , Read IARC Press Release 259
The Islamic Republic of Iran joins the International Agency for Research on Cancer
16/05/2018 -
The International Agency for Research on Cancer (IARC) is pleased to welcome the Islamic Republic of Iran as a new Participating State. The Islamic Republic of Iran today becomes the 26th country to join the Agency, sealing a long-standing relationship of collaboration between IARC and Iranian scientists.

Read IARC Press Release 258 , View photos
Hinari Access to Research for Health Programme
10/05/2018 -
The Hinari Programme, established by the World Health Organization (WHO) together with major publishers, enables institutions in low- and middle-income countries to gain access to one of the world’s largest collections of biomedical and health literature. Up to 14 000 journals (in 45 different languages), up to 56 000 e-books, and up to 120 other information resources are now available to health institutions around the world. As one of the publishers participating in the project, the International Agency for Research on Cancer (IARC) invites health workers and researchers to take advantage of this service, provided free or at very low cost. First check with your librarian or administrator whether your institution is already registered for Hinari access. If not, your librarian or administrator can apply for access. The Hinari helpdesk can assist.

Visit the Hinari website
IARC Postdoctoral Opportunities - Section/Group: Section of Nutrition and Metabolism/Nutritional Epidemiology Group
09/05/2018 -
A postdoctoral opportunity within the Nutritional Epidemiology Group is available from September 1st 2018 to contribute to molecular epidemiological analyses, including metabolomics, genome-wide and Mendelian randomization studies.

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Launch of Cancers Attributable to UV Radiation website
07/05/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce the launch of its new database on cancers attributable to ultraviolet (UV) radiation. Part of the Global Cancer Observatory (GCO), the platform aims to provide estimates of the preventable melanoma burden using a standardized analytical approach for all countries. The Cancers Attributable to UV Radiation website provides the population attributable fractions associated with UV radiation exposure and will help national decision-makers in setting priorities for cancer prevention.

View the website
Global burden of cutaneous melanoma attributable to ultraviolet radiation in 2012
07/05/2018 -
A new study by scientists from the International Agency for Research on Cancer (IARC) shows the urgent need to promote behaviour changes to decrease individual sun exposure, the leading cause of melanoma of the skin. The study, published today in the International Journal of Cancer, shows that globally an estimated 168 000 new cases of melanoma in 2012 were linked to excess exposure to ultraviolet radiation, 149 000 of which occurred in high-risk populations.

Arnold M, de Vries E, Whiteman DC, Jemal A, Bray F, Parkin DM, et al.
Global burden of cutaneous melanoma attributable to ultraviolet radiation in 2012
Int J Cancer. Published online 7 May 2018;
http://dx.doi.org/10.1002/ijc.31527

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Are two doses of human papillomavirus vaccine sufficient for girls aged 15–18 years? Results from a cohort study in India
30/04/2018 -
New findings from a cohort study in India, published in the journal Papilloma Research, show that two doses of human papillomavirus (HPV) vaccine are as efficacious as three doses in girls aged 15–18 years. Earlier findings from this multicentre trial, which was initiated by the International Agency for Research on Cancer (IARC) in 2009, contributed to the World Health Organization (WHO) Strategic Advisory Group of Experts on Vaccination’s 2014 recommendation of a two-dose HPV vaccine schedule for adolescent girls aged less than 15 years. Based on the new findings, the current two-dose recommendation may be revised and extended to girls up to 18 years of age.

Bhatla N, Nene BM, Joshi S, Esmy PO, Poli URR, Joshi G, et al.
Are two doses of human papillomavirus vaccine sufficient for girls aged 15-18 years? Results from a cohort study in India.
Papillomavirus Res. 5:163–171;
http://dx.doi.org/10.1016/j.pvr.2018.03.008

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No association between circulating concentrations of vitamin D and risk of lung cancer
27/04/2018 -
A new study from the International Agency for Research on Cancer (IARC) found no association between circulating vitamin D concentrations and lung cancer risk. The study, published in the Annals of Oncology, is the largest observational study to date to investigate whether high vitamin D concentrations may protect against lung cancer. Circulating vitamin D concentrations were measured in pre-diagnostic blood samples from 20 prospective cohorts participating in the Lung Cancer Cohort Consortium.

Muller DC, Hodge AM, Fanidi A, Albanes D, Mai XM, Shu XO, et al.
No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)
Ann Oncol. Published online 2 April 2018;
http://dx.doi.org/10.1093/annonc/mdy104

Read article , Read IARC Press Release 257
IARC Monographs Volume 115: Some Industrial Chemicals
25/04/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on “Some Industrial Chemicals” is now available online. This volume includes monographs on 1-bromopropane, 2-mercaptobenzothiazole, 3-chloro-2-methylpropene, N,N-dimethylformamide, N,N-dimethyl-p-toluidine, hydrazine, and tetrabromobisphenol A.

Visit the Volume 115 webpage
IARC Seminars: Using decision science methods to optimize cervical cancer prevention policies
20/04/2018 -
Title: Using decision science methods to optimize cervical cancer prevention policies
Speaker: Dr Jane J. Kim
Professor of Health Decision Science, Harvard T.H. Chan School of Public Health, Boston MA, USA

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IARC Monographs evaluation of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide
19/04/2018 -
The results of the recent IARC Monographs evaluation of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide have now been published in The Lancet Oncology. This summary article presents the conclusions of the IARC Monographs Meeting 121. The new evaluations of styrene and styrene-7,8-oxide update the previous evaluations by the IARC Monographs in 2002 and 1994, respectively. This is the first time an IARC Monographs Working Group has considered quinoline.

The full scientific assessment will be published as Volume 121 of the IARC Monographs.
IARC Monographs Vol. 121 Group
Lancet Oncol, Published online 18 April 2018 ;
http://dx.doi.org/10.1016/S1470-2045(18)30316-4

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IARC signs comprehensive Memorandum of Understanding with the University of Otago, New Zealand
18/04/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce the signature of a new Memorandum of Understanding (MoU) with the University of Otago, New Zealand. The MoU focuses on building capacity and specific research collaborations that will strengthen the evidence-base for cancer prevention and control. The areas of focus include cooperation on the development of cancer registration infrastructure in the Pacific region, research studies in the domains of cancer surveillance, aetiology and prevention, as well as exchange programmes supporting the education and training of early-career and senior scientists.

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IARC Postdoctoral Opportunities - Section/Group: Section of Genetics/Genetic Epidemiology Group
13/04/2018 -
A postdoctoral opportunity in Bioinformatics / Computational biology is immediately available within the Genetic Epidemiology Group to contribute to our multidisciplinary cancer studies which integrate epidemiology and genome-wide investigations (large-scale GWAS, exome/genome/transcriptome sequencing) together with medical history and clinical outcome of cancer patients from all over the world.

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Toward the World Code Against Cancer
11/04/2018 -
In an article published in the Journal of Global Oncology (JGO), researchers from the International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) propose the development of a World Code Against Cancer. The aim of such a Code, based on a set of authoritative, clear, evidence-based recommendations, is to help the general public take active steps to reduce their cancer risk. With the methodology developed by IARC for the European Code Against Cancer, Regional Codes could be developed to take into account regional differences in risk factors and cancer patterns.

Espina C, Herrero R, Sankaranarayanan R, Krug E, Wild CP, Schüz J
Toward the World Code Against Cancer
J Glob Oncol. Published online 2 April 2018;
http://dx.doi.org/10.1200/JGO.17.00145

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Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study
06/04/2018 -
A study led by researchers from the International Agency for Research on Cancer (IARC) and partners is comparing the effectiveness of a single dose of human papillomavirus (HPV) vaccine versus three or two doses to protect against persistent HPV infection, which is the necessary cause of cervical cancer. Early findings from this multicentre trial in India indicate that a single dose of quadrivalent HPV vaccine generates robust antibody response and provides similar protection against HPV16 and HPV18 persistent infections as immunization based on the three- or two-dose vaccine schedules.

Sankaranarayanan R, Joshi S, Muwonge R, Esmy PO, Basu P, Prabhu P, et al.; Indian HPV Vaccine Study Group
Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study
Vaccine. Published online 15 March 2018;
http://dx.doi.org/10.1016/j.vaccine.2018.02.087

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Training Course Opportunity, IARC, Lyon, France
03/04/2018 -
The International Agency for Research on Cancer (IARC) is organizing a training course "Statistical Practice in Epidemiology using R" on 14-20 June 2018. This 6-day course is targeting epidemiologists and statisticians willing to use R for statistical modelling and analysis of epidemiological data. You have only a few days left to register! The deadline for application is now extended to 8 April 2018.

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IARC Postdoctoral Opportunities - Section/Group: Section of Infections/Infections and Cancer Epidemiology Group
03/04/2018 -
A postdoctoral opportunity is immediately available for an epidemiologist/biostatistician at the International Agency for Research on Cancer (IARC). The Infections and Cancer Epidemiology (ICE) Group has developed expertise in quantitative and statistical methods to evaluate the possible determinants of sudden changes in cancer incidence, with the aim of informing prevention strategies for cancer.

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Epigenome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes
28/03/2018 -
A new study led by scientists from the International Agency for Research on Cancer (IARC) and from the National Cancer Center Seoul (Republic of Korea) investigated the impact of both current and past (eradicated) Helicobacter pylori infection on epigenome-wide changes in normal gastric mucosa collected from study participants in the Republic of Korea. This is the first report of the epigenome-wide analysis of normal gastric mucosa taken from cases and controls representing both H. pylori and gastric cancer status, and the comprehensively characterized epigenome changes might serve as potential biomarkers for early cancer progression in tumour-free gastric mucosa in nationwide gastric cancer screening programmes.

Woo HD, Fernandez-Jimenez N, Ghantous A, Degli Esposti D, Cuenin C, Cahais V, et al.
Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes
Int J Cancer. Published online 25 March 2018;
http://dx.doi.org/10.1002/ijc.31381

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IARC Handbooks of Cancer Prevention Volume 17: Colorectal Cancer Screening
27/03/2018 -
A Working Group of 23 independent international experts met at the International Agency for Research on Cancer (IARC) on 14–21 November 2017 to evaluate the effectiveness of various colorectal cancer screening methods. A summary of the outcome of the meeting is published today as a Special Report in The New England Journal of Medicine. The detailed assessments will be published as Volume 17 of the IARC Handbooks of Cancer Prevention.

The IARC perspective on colorectal cancer screening
Lauby‑Secretan B, Vilahur N, Bianchini F, Guha N, Straif K.
N Engl J Med. Published online 27 March 2018;
http://dx.doi.org/10.1056/NEJMsr1714643

Read more , Read IARC Press Release 256
IARC Monographs Meetings - Volume 121: Styrene, Styrene-7,8-oxide, and Quinoline
19/03/2018 -
IARC Monographs Volume 121: Styrene, Styrene-7,8-oxide, and Quinoline
20-27 March 2018
Lyon, France

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The impact of overdiagnosis on thyroid cancer epidemic in Italy, 1998–2012
16/03/2018 -
A new study led by researchers from the Aviano National Cancer Institute in Italy and the International Agency for Research on Cancer (IARC), published today in the European Journal of Cancer, shows that incidence rates of thyroid cancer are steadily increasing in Italy, although with large regional variations, and that these increases are largely due to overdiagnosis, which is estimated to account for up to 75% of cases. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.

Dal Maso L, Panato C, Franceschi S, Serraino D, Buzzoni C, Busco S, et al.; for AIRTUM working group
The impact of overdiagnosis on thyroid cancer epidemic in Italy, 1998–2012
Eur J Cancer [Epub ahead of print]
http://dx.doi.org/10.1016/j.ejca.2018.01.083

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IARC Seminars: The Future of Science in Africa
14/03/2018 -
Title: The Future of Science in Africa
Speaker: Dr Thomas Kariuki
Director, Alliance for Accelerating Excellence in Science in Africa (AESA), African Academy of Sciences

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Physical activity, sedentary behaviour, and colorectal cancer risk
09/03/2018 -
A new study by scientists from the International Agency for Research on Cancer (IARC), published today in the British Journal of Cancer (BJC), investigates the link between levels of physical activity and risk of colorectal cancer. Using observational studies based on more than 430 000 men and women in the United Kingdom, the study showed that higher levels of physical activity were associated with lower risk of colon cancer and that higher levels of sedentary behaviour (television watching) were associated with increased risk of colon cancer.

Morris JS, Bradbury KE, Cross AJ, Gunter MJ, Murphy N
Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank
BJC Published online 9 March 2018;
http://dx.doi.org/10.1038/bjc.2017.496

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Inferring causal pathways from data: challenges and some solutions
08/03/2018 -
Title: Inferring causal pathways from data: challenges and some solutions
Speaker: Dr Stijn Vansteelandt, Professor of Statistics Department of Applied Mathematics, Computer Science and Statistics
Ghent University, Ghent, Belgium &
Professor of Statistical Methodology,
Department of Medical Statistics,
London School of Hygiene and Tropical Medicine
London, UK

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IARC rejects false claims in Reuters article: WHO cancer agency “left out key findings” in benzene review
01/03/2018 -
IARC strongly rejects the premise of the article published on 28 February 2018 by Reuters (WHO cancer agency “left out key findings” in benzene review). No key findings were left out of the IARC evaluation of benzene as a cause of cancer, and IARC provided extensive responses to Dr Kopstein’s questions. The article, which severely distorts the assessment of the IARC Monographs evaluation, is the latest in a series of misleading reports by Reuters. In the best interests of global public health and transparency, IARC is posting its full response to the journalist on its website, as it has consistently done.

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Workshop: Social inequalities and cancer
22/02/2018 -
On 16–18 April 2018, more than 30 multidisciplinary international experts will gather at the International Agency for Research on Cancer (IARC) for a three-day workshop on social inequalities and cancer. The experts will focus on the current evidence, mechanisms, research gaps, and possible solutions to tackle social inequalities in cancer. The results of the workshop will be published as an IARC Scientific Publication, and a scientific summary will be released after the workshop.

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Métropole de Lyon and IARC unveil plans for new IARC building
20/02/2018 -
After an 18-month international competitive bidding process for the design and construction of the “Nouveau Centre” (combined design-build contract) for the International Agency for Research on Cancer (IARC), the winning team has been selected by the Métropole de Lyon. The team consists of Demathieu Bard (general contractor), Art&Build (architects), Unanime (architects), WSP (design engineering company), and Inddigo (sustainable development engineering company). The project is managed by the Métropole de Lyon and funded by the French government, the Métropole de Lyon, the Région Auvergne-Rhône-Alpes, and the Ville de Lyon.

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IARC Monographs meeting: Advisory Group to Recommend an Update to the Preamble (12–14 November 2018)
19/02/2018 -
In 2018, the International Agency for Research on Cancer (IARC) will amend the Preamble to the IARC Monographs. The Preamble describes the principles and procedures used in developing IARC Monographs, including the scientific criteria that guide the evaluations. The Preamble is updated periodically. The objective of this update is to reflect scientific developments and procedural changes that have occurred since the Preamble was last amended, in 2006.

Call for Experts (closing date 2 April 2018)
Request for Observer Status (closing date 12 June 2018)

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International Childhood Cancer Day 2018
15/02/2018 -
Each year, more than 200 000 children worldwide are diagnosed with cancer. Although in high-income countries about 80% of children with cancer survive for at least 5 years after the diagnosis, this percentage is much lower for patients in low-resource settings. Raising awareness, notably among medical professionals in countries with many competing public health needs, is indispensable to promote early diagnosis and access to adapted treatment. The International Agency for Research on Cancer (IARC) works closely with cancer registries and partners around the world to generate and provide global data, which are essential for developing and monitoring efficient strategies of early detection and care for children with cancer.

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World Cancer Day 2018
06/02/2018 -
Every year on World Cancer Day (4 February), the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) support the Union for International Cancer Control (UICC) in promoting ways to reduce the global burden of cancer.

To mark World Cancer Day 2018, IARC Director Dr Christopher Wild explains how research plays a key role in helping to improve our understanding of what causes cancer as well as in defining the best ways to prevent and control the disease.

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World Cancer Day 2018: 5th IARC Cancer and Society Lecture
01/02/2018 -
To mark World Cancer Day 2018, the International Agency for Research on Cancer (IARC) is pleased to welcome Professor Daniel R. Fagin to present the 5th IARC Cancer and Society Lecture. Professor Fagin is a Pulitzer Prize-winning journalist, a professor at New York University, and author of the bestselling book Toms River: A Story of Science and Salvation. In his talk, “From Toms River to Today: Science, Spin and Storytelling in Dark Times”, Professor Fagin explores how researchers, clinicians, policy-makers, and the media can make progress only by maximizing transparency, leveraging networks, prioritizing trust-building, and, most importantly, communicating effectively.

5th IARC Cancer and Society lecture
Tuesday 6 February 2018 at 11:00 am

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Cancer surveillance in northern Africa, and central and western Asia: challenges and strategies in support of developing cancer registries
01/02/2018 -
A policy review published today in The Lancet Oncology as part of the journal’s Global Oncology series presents the activities of the IARC Hub for Cancer Registration in Northern Africa, Central and Western Asia within the Global Initiative for Cancer Registry Development (GICR, http://gicr.iarc.fr/). The IARC authors, together with the Hub Principal Investigator and Advisory Committee members from the region, advocate tailored approaches given the rapidly changing cancer profiles and the challenges faced at the national level. The review provides an overview of the activities regionally and nationally, and documents how registries are informing cancer control policies that can curb the increasing cancer burden across the region.

Znaor A, Eser S, Anton-Culver H, Fadhil I, Ryzhov A, Silverman BG, et al.
Cancer surveillance in northern Africa, and central and western Asia: challenges and strategies in support of developing cancer registries
Lancet Oncol. Published online 1 February 2018
https://doi.org/10.1016/S1470-2045(18)30019-6

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$46 billion in productivity lost to cancer in major emerging economies
31/01/2018 -
A new study published today in the journal Cancer Epidemiology evaluates for the first time the cost of productivity lost due to premature cancer deaths in several major emerging economies. Led by the International Agency for Research on Cancer (IARC) in partnership with leading cancer research institutions in these countries, the study shows that the productivity loss in Brazil, the Russian Federation, India, China, and South Africa, collectively known as the BRICS countries, reached $46.3 billion in 2012.

Pearce A, Sharp L, Hanly P, Barchuk A, Bray F, de Camargo Cancela M, et al.
Productivity losses due to premature mortality from cancer in Brazil, Russia, India, China, and South Africa (BRICS): a population-based comparison
Cancer Epidemiol. [Epub ahead of print]
http://dx.doi.org/10.1016/j.canep.2017.12.013

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Cervical Cancer Awareness Month: the ESTAMPA study
30/01/2018 -
Cervical cancer is a serious public health problem worldwide. More than 520 000 new cases of cervical cancer and nearly 250 000 deaths occur per year, and 90% of the cases occur in low- and middle-income countries. Cervical screening with cytology includes frequent smears and follow-up visits, a model too complex for women with limited access to care. The ESTAMPA study is an international research project in Latin America led by the International Agency for Research on Cancer (IARC) to evaluate approaches to organized human papillomavirus (HPV)-based cervical screening and reduce cervical cancer mortality in the region.

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The future burden of colorectal cancer among US Blacks and Whites
30/01/2018 -
A new study published in the Journal of the National Cancer Institute predicts that colorectal cancer incidence rates will rise over the next three decades, particularly among US Whites. However, the disparity between US Blacks and Whites is predicted to persist, with a higher incidence rate among US Blacks. The study, led by researchers from the International Agency for Research on Cancer (IARC), suggests that improved prevention programmes, including early detection, may reduce the future disease burden and decrease the disparity between US Blacks and Whites.

Araghi M, Fidler MM, Arnold M, Jemal A, Bray F, Soerjomataram I
The future burden of colorectal cancer among US Blacks and Whites
J Natl Cancer Inst. Published online 23 January 2018;
http://dx.doi.org/10.1093/jnci/djx287

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Launch of new Kathmandu population-based cancer registry
23/01/2018 -
The Ministry of Health of Nepal has launched a new Kathmandu population-based cancer registry to collect essential data on nearly 3 million inhabitants of the Kathmandu Valley. Working closely with the Nepal Health Research Council (NHRC), the IARC Global Initiative for Cancer Registry Development (GICR) is providing technical guidance through its capacity-building programme. The IARC Mumbai Regional Hub for Cancer Registration at the Tata Memorial Centre recently hosted a week-long training course for a team of five participants from Nepal, and workshops were held in Kathmandu to review plans and seek input from key stakeholders for the registry.

View GICR website
IARC Postdoctoral Opportunities – Section of Nutrition and Metabolism/Nutritional Methodology and Biostatistics Group
18/01/2018 -
A postdoctoral opportunity is available immediately within the Group to work on an integrated approach to combine self-reported and biomarker estimates of dietary exposure, with the aim of exploring the misclassification inherent in these measurements.
Deadline: 31 March 2018

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IARC Internal Seminar: 11th Richard Doll Lecture: Opium as a carcinogen: new insights from the Golestan Cohort Study
15/01/2018 -
11th Richard Doll Lecture
Title: Opium as a carcinogen: new insights from the Golestan Cohort Study
Speaker: Professor Reza Malekzadeh, Director, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Islamic Republic of Iran

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Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice
12/01/2018 -
Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer, the most common form of human cancer. A new study by researchers from the International Agency for Research on Cancer (IARC) and the German Cancer Research Center (DKFZ), published today in PLoS Pathogens, used a transgenic mouse model in which the expression of beta HPV38 oncogenes can be modulated in the skin. Their findings support the concept that beta HPV types act only at an initial stage of carcinogenesis, by potentiating the deleterious effects of UV radiation.

Viarisio D, Müller-Decker K, Accardi R, Robitaille A, Dürst M, Beer K, et al.
Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice
PLoS Pathog, Published online 11 January 2018
http://dx.doi.org/10.1371/journal.ppat.1006783

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IARC Monographs Volume 113: DDT, Lindane, and 2,4-D
09/01/2018 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on the insecticides dichlorodiphenyltrichloroethane (DDT) and gamma-hexachlorocyclohexane (lindane) and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is now available online.

Visit the Volume 113 webpage
IARC Postdoctoral Opportunities – Section of Nutrition and Metabolism/Nutritional Methodology and Biostatistics Group
03/01/2018 -
A postdoctoral opportunity is immediately available within the Nutritional Methodology and Biostatistics Group to work on the identification of aetiological factors in the occurrence of multi-morbidity and cancer comorbidity. The postdoctoral scientist will join an innovative and scientifically stimulating environment and will have opportunities to interact and collaborate with colleagues from IARC and its networks.

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