Media Centre - IARC NEWS

2011

IARC Publications - IARC Handbook of Cancer Prevention -Volume 14
19/12/2011 -
Effectiveness of Tax and Price Policies for Tobacco Control
IARC Handbook of Cancer Prevention vol. 14

This new volume of the IARC Handbooks of Cancer Prevention in Tobacco Control presents a critical review and evaluation of the evidence by 25 international experts from twelve countries on the economics, epidemiology, public policy and tobacco control aspects of tax and price policies. The working group draws conclusions about the effectiveness of tax and price measures to control tobacco use in the population.

The Handbook covers an overview of tobacco taxation; industry pricing strategies and other industry initiatives diluting the effects of taxes on consumption; tax, price and aggregated demand for tobacco, as well as demand at the individual level in adults, young people and the economically disadvantaged; tax avoidance and tax evasion and the economic and health impacts of tobacco taxation.

This body of evidence and the consensus evaluation of 18 concluding statements on the impact of interventions to increase the price of tobacco products, can assist policy makers, government officials, evaluators and researchers working in tobacco control and disease prevention, to base their decisions on the latest scientific evidence.
Order at WHOPress
Global cancer prevalence available at the GLOBOCAN 2008 website
14/12/2011 -
The International Agency for Research on Cancer announces today the availability of global cancer prevalence estimates through its GLOBOCAN 2008 website. Cancer prevalence helps provide information on resource needs for patients by measuring the absolute number and the relative proportion in populations of individuals living with the disease and potentially requiring some form of clinical or support service.

Read more , Link to Globocan 2008 website
JNCI J Natl Cancer Inst - Preventable Exposures Associated With Human Cancers
13/12/2011 -
This year, the IARC Monographs Programme completed its review of the human carcinogens identified over its 40 years of activity. The IARC Monographs publishes today in the Journal of the National Cancer Institute an overview of established human carcinogens, along with target organ sites, which now allows searches either by exposure, or by organ site, a crucial novelty for epidemiologists and public health scientists and decision-makers alike.


Preventable Exposures Associated With Human Cancers
V J Cogliano, R Baan, K Straif, Y Grosse, B Lauby-Secretan, F El Ghissassi, V Bouvard, L Benbrahim-Tallaa, N Guha, C Freeman, L Galichet, C P Wild
J Natl Cancer Inst 2011;103:1–14 DOI: 10.1093/jnci/djr483
See IARC Monographs website

Read article (Open access after registration to JNCI)
Postdoctoral Opportunities
12/12/2011 -
Call for applications for a postdoctoral opportunity in the Section of Environment and Radiation.
Deadline: 12/01/2012

An update of the IARC publication ‘Cancer Epidemiology: Principles and Methods’ by Isabel dos Santos Silva, originally published in 1999, has been initiated. A one-year postdoctoral opportunity is available to work on the update of the book.

More information
Senior Visiting Scientist Award 2011
05/12/2011 -
The recipients of this year’s highly competitive Senior Visiting Scientist Award are

Professor Anssi Auvinen from the Tampere School of Public Health, University of Tampere, Tampere, Finland,

Professor Joakim Dillner from the Department of Medical Epidemiology & Biostatistics, Karolinska Institute, Stockholm, Sweden,

Professor Anna Giuliano from the Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA, and

Professor Nanny Wermuth from the Department of Mathematics, Division of Mathematical Statistics, Chalmers University of Technology & University of Gothenburg, Gothenburg, Sweden.

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The Lancet Oncology - News: Recent developments for cancer care in Africa
01/12/2011 -
The News section of the Lancet Oncology, dated November 25, echoes the launch by IARC and partners of the Global Initiative for Cancer Registry Development in Low- and MiddleIncome Countries (GICR), calling for action from donors and intergovernmental organizations: fostering cancer registration in low- and middle-income countries is vital for a better mapping of cancer in those underserved areas, which will help implementing strategies for cancer management and control.
Talha Khan Burki
The Lancet Oncology, Early Online Publication, 25 November 2011
doi:10.1016/S1470-2045(11)70341-2
Read article , GICR website
IARC Summer School in Cancer Epidemiology 2012
30/11/2011 -
Summer School in Cancer Epidemiology
18 June to 6 July 2012
The deadline for applications is 16 January 2012
Download Course Schedule and Forms
The Lancet Oncology - Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons
28/11/2011 -
Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons.
B Lauby-Secretan, R Baan, Y Grosse, F El Ghissassi, V Bouvard, L Benbrahim-Tallaa, N Guha, L Galichet, K Straif, on behalf of the WHO IARC Monograph Working Group
The Lancet Oncology, Volume 12, Issue 13, Pages 1190 - 1191, December 2011
doi:10.1016/S1470-2045(11)70359-X

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Cancer / Radiothérapie - New insights in oncology: Epigenetics and cancer stem cells
24/11/2011 -
A large number of genes, critical for cell growth, death, differentiation, migration, and metabolic plasticity are altered irreversibly, and either “gain” (oncogenes) or “lose” (tumour suppressors) their function. Recent discoveries have revealed the previously underestimated etiologic importance of multiple epigenetic, that is to say, reversible factors involved in the transcriptional and post-transcriptional regulation of proteins, indispensable for the control of cancerous phenotype. Stable alterations of epigenetic machinery (“epimutations”) turn out to play a critical role at different steps of carcinogenesis.

In addition, due to substantial recent progress in stem cell biology, the new concept of cancer stem cells has emerged. This, along with newly discovered epigenetic cancer mechanisms, gives rise to a hope to overcome radio- and chemo-resistance and to eradicate otherwise incurable neoplasms.

V Krutovskikh, C Partensky
New insights in oncology: Epigenetics and cancer stem cells
Cancer / Radiothérapie Doi : 10.1016/j.canrad.2011.05.012
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Postdoctoral Opportunities
21/11/2011 -
Call for applications for a postdoctoral opportunity in the Section of Nutrition and Metabolism/Biomarkers Group.
Read more.
International cancer community welcomes Global Initiative for Cancer Registry Development in Low- and Middle-Income Countries
18/11/2011 -
Lyon, France – Cancer control professionals at the World Cancer Leaders’ Summit (Dublin, Ireland), welcomed a new initiative convened by the International Agency for Research on Cancer (IARC).
Backed by several major organizations, the Global Initiative for Cancer Registry Development in Low- and Middle-Income Countries (GICR) aims at building –and creating where needed– the capacity to produce reliable, high-quality information on the burden of cancer so that effective policies for cancer control may be developed and implemented.

Read more , Link to GICR website
INCA-ASCO Forum on Hereditary Cancer and Genetic Predisposition to Cancer
17/11/2011 -
IARC is happy to take part in the INCA-ASCO Forum on Hereditary Cancer and Genetic Predisposition to Cancer, an international conference in Rio de Janeiro, November 20 - 21, 2011.
Dr Pierre Hainaut, Head of IARC’s Molecular Carcinogenesis Section collaborates with a number of investigators of the Brazilian network on a regular basis.
Promoting the issues raised by the growing demand for genetic cancer risk assessment and the need for expanded genetic testing capacity at all levels is key, and IARC is particularly happy to formally endorse this important meeting for the future of cancer research in the Americas.

INCA-ASCO Forum website , See Program
Launch of the IARC Biobank website
07/11/2011 -
The IARC Biobank (IBB) hosts one of the largest, most varied and richest international human sample collections in the world (over 5 million). The resource contains both population-based collections from research projects focusing on gene-environment interactions and disease-based collections which focus on biomarker studies. Most of the samples are body fluids, including plasma, serum and urine as well as extracted DNA samples.
One of IARC’s chief functions is to promote international scientific cooperation. The ongoing cataloguing of bio-specimens and studies within this new resource will foster new collaborative opportunities between the Agency and scientists world-wide.

Link to the IARC Biobank website
Dermatology Times: HPV strain, UVB exposure spurs development of squamous cell carcinoma
03/11/2011 -
An interview of Dr M. Tommasino for Dermatology Times: HPV infection may play a role in non-melanoma skin cancer.
Dr Tommasino illustrated the findings recently published in PLoS Pathogens, which showed synergies between HPV oncoproteins and UV irradiation in an animal model. 
Read interview , Read Article (PloS Pathogens website)
Molecular and Cellular Biology - Mammalian Ino80 Mediates Double Strand Break Repair through Its Role in DNA End Strand Resection
02/11/2011 -
DNA molecule within each human cell is constantly exposed to an array of damaging agents from environmental sources and recent molecular studies have identified sophisticated mechanisms by which cells efficiently repair DNA breaks. Researchers of IARC’s Epigenetics Group discovered how the repair machinery gains access to broken DNA in highly compacted chromatin. An epigenetic modifier (known as the chromatin-remodelling factor gene INO80) was found to play a critical role in DNA repair of double strand breaks in human cells and that INO80-mediated DNA repair is evolutionary conserved. Because proficient DNA repair is essential for genomic stability, deregulation of this mechanism may result in induction of mutations, leading to an aberrant inactivation of tumour suppressor genes and promotion of tumorigenesis.

A Gospodinov, T Vaissiere, DB Krastev, G Legube, B Anachkova, and Z Herceg.
Mammalian Ino80 Mediates Double Strand Break Repair through Its Role in DNA End Strand Resection
Mol. Cell. Biol., doi: doi:10.1128/MCB.06182-11

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PLoS Medicine - STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement
26/10/2011 -
The new STROBE-ME Guidelines, developed in partnership with IARC scientists, are being published today by PLoS Medicine.
The new guidelines provide an easy to use checklist for the accurate and ethical reporting of epidemiological studies involving molecular markers.

STrengthening the Reporting of OBservational studies in Epidemiology — Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement.
V Gallo, M Egger, V McCormack, PB Farmer, JPA Ioannidis, M Kirsch-Volders, G Matullo, DH Phillips, B Schoket, U Stromberg, R Vermeulen, C Wild, M Porta, P Vineis.
PLoS Med 8(10): e1001117. doi:10.1371/journal.pmed.1001117, Published: October 25, 2011

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BMJ - Use of mobile phones and risk of brain tumours: update of Danish cohort study
21/10/2011 -
Researchers of the Institute of Cancer Epidemiology, Danish Cancer Society, and of IARC’s Section of Environment and Radiation have published an update of a Danish nationwide cohort study of mobile phone subscribers in the British Medical Journal today. 358,403 subscription holders accrued 3.8 million person years for follow up for tumours of the central nervous system. The study did not show an increased risk of any type of central nervous system tumour, including in the group of longest term mobile phone subscribers of 13 years or more. There was also no indication for an increased risk of the most common sub-types of brain tumours, glioma and meningioma. In all, the study provides little evidence for a causal association between mobile phone use and risk of brain tumours, but cannot rule out risks after induction periods of 15 years or longer, or small to moderate increases in heavy users of mobile phones. Further research into the cancer-causing potential of mobile-phone use is warranted.

P Frei, AH Poulsen, C Johansen, JH Olsen, M Steding-Jessen M and J Schüz.
Use of mobile phones and risk of brain tumours: update of Danish cohort study
BMJ 2011;343:d6387 doi: 10.1136/bmj.d6387 (Published 20 October 2011)
Read article , Read Questions and Answers
IARC Monographs - Occupational exposures to bitumens and their emissions
20/10/2011 -
The WHO/International Agency for Research on Cancer’s Monographs programme re-evaluated various occupations that entail exposures to bitumens and bitumen emissions, including road paving, roofing, and application of mastic asphalt.
After an 8-day comprehensive review, the Working Group concluded that:
 - occupational exposures to oxidized bitumens and their emissions during roofing are ‘probably carcinogenic to humans’ (Group 2A);
 - occupational exposures to hard bitumens and their emissions during mastic asphalt work are ‘possibly carcinogenic to humans’ (Group 2B); and
 - occupational exposures to straight-run bitumens and their emissions during road paving are ‘possibly carcinogenic to humans’ (Group 2B).

Read more , IARC Monographs website
IARC Publications - PDFs online - Pathology and Genetics of Tumours of the Breast and Female Genital Organs
18/10/2011 -
Pathology and Genetics of Tumours of the Breast and Female Genital Organs is now available in PDF format. This book covers the female and male breast, ovaries, fallopian tumours, uterine cervix, uterine corpus, vulva, vagina and inherited tumour syndromes.

Download
Cancer Epidemiology - Africa's growing cancer burden: Environmental and occupational contributions
17/10/2011 -
Environmental and occupational exposures, often modifiable, contribute to Africa’s cancer burden, projected to double between 2008 and 2030. This article highlights circumstances present in certain African settings that give rise to high levels of exposure and unique exposure patterns to established and possibly carcinogenic agents at work and in the external environment. They present research opportunities informative for cancer aetiology in general and for local cancer burdens.

V. McCormack, J Schüz
Africa's growing cancer burden: Environmental and occupational contributions
Cancer Epidemiology, Published online 30 September 2011, doi: 10.1016/j.canep.2011.09.005

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Grants supporting IARC research projects : One-carbon Metabolism Biomarkers and Lung cancer risk
14/10/2011 -
The Genetic Epidemiology Group (GEP) at IARC has been awarded nearly $5 million to support  research in the area of one-carbon metabolism biomarkers  and lung cancer risk.
More information , GEP web page
Grants supporting IARC research projects: Pooled genome-wide analysis of kidney cancer risk
14/10/2011 -
The Genetic Epidemiology Group (GEP) at IARC has been awarded nearly $4.5 million to support  the project 'Pooled genome-wide analysis of kidney cancer risk'.
More information , GEP web page
Postdoctoral Fellowships: New IARC-Ireland postdoctoral fellowship
12/10/2011 -
IARC announces a new fellowship: "IARC-Ireland postdoctoral fellowship" for training in cancer research, supported by the Irish Cancer Society.
Call for applications now open!
Deadline 31 December 2011

See details
Postdoctoral Opportunities
11/10/2011 -
Call for applications for a postdoctoral opportunity in the Section of Environment and Radiation.

An update of the IARC publication ‘Cancer Epidemiology: Principles and Methods’ by Isabel dos Santos Silva, originally published in 1999, has been initiated. A one-year postdoctoral opportunity is available to work on the update of the book.
Read more
JNCI - Clinical Breast Examination: Preliminary Results from a Cluster Randomized Controlled Trial in India
28/09/2011 -
Early detection and appropriate treatment is the major approach for breast cancer control. However, mammography screening is neither feasible nor affordable in many developing countries where breast cancer incidence is rapidly increasing. The Regional Cancer Centre, Trivandrum, India and the International Agency for Research on Cancer initiated a cluster randomized controlled trial involving 116,000 women in the Trivandrum district (India) in 2006 to evaluate whether three rounds of triennial clinical breast examination (CBE), an alternative to mammography screening,  can reduce the inci­dence of advanced disease and breast cancer mortality. Preliminary results after one round of screening indicates two fold increased earlier detection of breast cancer in women randomized to CBE screening as compared to women receiving routine existing care in the control group. Further follow-up will clarify if whether earlier detection following CBE screening will lead to significant reduction in breast cancer mortality.
   
R Sankaranarayanan, K Ramadas, S Thara, R Muwonge, J Prabhakar, et al.
Clinical Breast Examination: Preliminary Results from a Cluster Randomized Controlled Trial in India
JNCI J Natl Cancer Inst (2011) doi: 10.1093/jnci/djr304

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Postdoctoral Opportunities
26/09/2011 -
Call for applications for a postdoctoral opportunity in the Section of Nutrition and Metabolism/ Nutritional Epidemiology Group.
Read more
Annals of Oncology - Alcohol drinking and colorectal cancer risk: an overall and dose–response meta-analysis of published studies
22/09/2011 -
The International Agency for Research on Cancer concluded that alcohol consumption is related to colorectal cancer. This study provides strong evidence for an association between alcohol drinking of >1 drink/day and colorectal cancer risk. The results from this large meta-analysis have important public health implications, given the large number of women and, especially, men consuming alcohol and the high incidence of colorectal cancer worldwide and in developed countries in particular.
V Fedirko, I Tramacere, V Bagnardi, M Rota, L Scotti, F Islami, E Negri, K Straif, I Romieu, C La Vecchia, P Boffetta, and M Jenab.
Alcohol drinking and colorectal cancer risk: an overall and dose–response meta-analysis of published studies
Ann Oncol (2011) 22(9): 1958-1972 doi:10.1093/annonc/mdq653

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A new detailed report on worldwide cancer statistics
21/09/2011 -
Cancer Research UK and the International Agency for Research on Cancer, in the framework of the UN High level Meeting on Non-Communicable Diseases, published on 19 September a new detailed report on the rise of cancer in the developing world.

See Report
HPV Vaccine Study raises Hope for Cancer Prevention
20/09/2011 -
Human papillomavirus (HPV) causes cervical cancer which is the second most common cancer in women worldwide. HPV infections also contribute to cancers of the anus, vagina, vulva, penis, and some oropharyngeal cancers.
New research on cancer-causing HPV has confirmed the vaccine's effectiveness and opened new avenues for research. The results, reported in three separate studies, suggest that vaccination programs could be less expensive than anticipated and may also have unexpected benefits.
Read more , Read NCI Cancer Bulletin
The Lancet Oncology - Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: a pooled analysis of 26 epidemiological studies
14/09/2011 -
The present findings on the protective effect of IUD against cervical cancer is yet another achievement of a 25-year old collaboration coordinated by IARC in 15 countries. It is a good reminder that even though the central role of HPV and cervical cancer is well-established, there remain other factors (e.g., contraceptive and reproductive practices, female hormones) that exert an influence on the probability of HPV infection to progress into cervical cancer.They deserve to continue being studied.

X Castellsagué, M Díaz, S Vaccarella, S de Sanjosé, N Muñoz, R Herrero, S Franceschi, et al.
Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: a pooled analysis of 26 epidemiological studies.
The Lancet Oncology, Early Online Publication, 13 September 2011, doi:10.1016/S1470-2045(11)70223-6

Read Article
UICC Fellowships News - Testimonial from IARC expert, Dr Rengaswamy Sankaranarayanan
12/09/2011 -
UICC features Dr Rengaswamy Sankaranarayanan, Head of IARC's Early Detection and Prevention Section (EDP), and a once-time ICRETT fellow.
Read more , Link to the page EDP
Call for Data - Cancer Incidence in Five Continents - Volume X
02/09/2011 -
On September 1st 2011, in collaboration with the International Association of Cancer Registries (IACR), IARC launched a call for datasets to be included in a new volume of Cancer Incidence in Five Continents (CI5). This important publication represents the definitive compilation of cancer incidence statistics from high-quality population-based cancer registries and is an invaluable resource for cancer researchers and those involved in cancer control worldwide. Volume X will provide results for cancers incident in the period 2003-2007. The deadline for receipt of data is December 1st 2011.
Read more , Visit CI5 website
Launch of the IARC Postdoctoral Fellowship Charter
01/09/2011 -
The Charter has been introduced in an effort to reinforce generic training as requested by IARC Fellows and Postdocs and to provide a more structured approach to performance evaluation and career development.

See details
International Journal of Cancer - A million africans a year dying from cancer by 2030: What can cancer research and control offer to the continent?
01/09/2011 -
B.S. Sylla , C.P. Wild
A million africans a year dying from cancer by 2030: What can cancer research and control offer to the continent?
Int J Cancer. Article first published online: 30 August 2011 doi: 10.1002/ijc.26333. [Epub ahead of print]

In an article published in the International Journal of Cancer, Dr Christopher Wild, IARC Director, and Dr Bakary Sylla, IARC scientist, call on African Governments to prioritise cancer through national cancer control plans and international partners to provide complementary support. The startling rise in cancer figures projected for Africa by 2030 (1.27 million new yearly cases and 0.97 million deaths) indicates that improving cancer treatment will be insufficient to deal with increases of this magnitude; the coming cancer epidemic must be addressed through prevention and early detection. For example, vaccination against HBV and HPV would prevent two of Africa’s most common cancers (liver and cervix, respectively), and measures to stop the spread of tobacco use would have significant impact as well. Beyond these immediate public health measures, research is needed to identify strategies and barriers to implementation. All of these efforts will require a firm commitment from African governments and complementary support from their international partners to mitigate the impending tragedy of cancer in Africa.
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Cancer Epidemiology - Acoustic neuroma risk in relation to mobile telephone use: Results of the INTERPHONE international case–control study
24/08/2011 -
The INTERPHONE Study Group
Acoustic neuroma risk in relation to mobile telephone use: Results of the INTERPHONE international case–control study
doi:10.1016/j.canep.2011.05.012, Available online 23 August 2011.

Today, another paper from the multinational IARC-coordinated case-control study on mobile phone use and the risk of brain tumours (Interphone) was published in “Cancer Epidemiology”. The study included 1105 patients with newly diagnosed acoustic neuroma (vestibular schwannoma) and 2145 controls from 13 countries. There was no increase in risk of acoustic neuroma with ever regular use of a mobile phone or for users who began regular use 10 years or more before diagnosis. Elevated risks observed at the highest level of cumulative call time could be due to chance, reporting bias or a causal effect.

Read Article
Postdoctoral Opportunities
22/08/2011 -
Call for applications for a postdoctoral opportunity in the Section of Environment and Radiation.
Read more
British Journal of Cancer - Trends in breast, ovarian and cervical cancer incidence in Mumbai, India over a 30-year period, 1976-2005: an age-period-cohort analysis
22/08/2011 -
P. K. Dhillon, B. B. Yeole, R. Dikshit, A. P. Kurkure and F. Bray
Trends in breast, ovarian and cervical cancer incidence in Mumbai, India over a 30-year period, 1976–2005: an age–period–cohort analysis
British Journal of Cancer advance online publication 9 August 2011; doi:10.1038/bjc.2011.301

The article, published in the British Journal of Cancer, studied period and cohort trends in female-specific cancers in Mumbai, India during the period 1976 and 2005 using incidence data from the Mumbai Cancer Registry. The authors found that while breast cancer incidence rates significantly increased at 1.1% per year on average, there were compensatory significant declines of 1.8% per year in rates of cervix cancer. A number of factors are likely responsible for the changing risk profile among younger generations. In general terms, they likely include a changing prevalence and distribution of the key lifestyle and reproductive determinants for these cancers among Mumbai women, brought about in part by increasing average levels of education and socioeconomic status.
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JNCI - Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case–Control Study
28/07/2011 -
D. Aydin, M. Feychting, J. Schüz, T. Tynes, T. Veje Andersen, et al.
Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case–Control Study
JNCI Advance Access published online July 27, 2011. doi:10.1093/jnci/djr244

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Emerging Oncogenic Viruses, 30 May - 3 June 2012, San Pietro in Bevagna, Italy
27/07/2011 -
This meeting is a joint IARC/DKFZ initiative, which will focus on discussions and the critical evaluation of epidemiology, immunology and biology of cancer-associated viruses.

Visit website
Some cutaneous HPV types may be involved in Non-Melanoma Skin Cancer development
18/07/2011 -
In a joint paper published on July 14, 2011 in PloS Pathogens, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the WHO's International Agency for Research on Cancer (WHO/IARC) conclude that a viral infection with a certain type of human papillomavirus may cooperate with UV light exposure in the development of non-melanoma skin cancer (NMSC).
Read More , Read Article (PloS Pathogens website)
The Lancet Oncology - Carcinogenicity of Radiofrequency Electromagnetic Fields
22/06/2011 -
The Lancet Oncology, Early Online Publication, 22 June 2011
doi:10.1016/S1470-2045(11)70147-4
Carcinogenicity of Radiofrequency Electromagnetic Fields
R Baan, Y Grosse, B Lauby-Secretan, F El Ghissassi, V Bouvard, L Benbrahim-Tallaa, N Guha, F Islami, L Galichet, K Straif, on behalf of the WHO IARC Monograph Working Group

Read article
IARC Fellowships
21/06/2011 -
Call for applications now open for IARC Fellowships:
-   Postdoctoral Fellowship programme
-   IARC-Australia Fellowship
-   Expertise Transfer Fellowship
-   Senior Visiting Scientist Award
Deadline 30 November 2011

See details
IARC Monographs Volume 105 - Upcoming Meetings
08/06/2011 -
IARC Monographs Volume 105:  Diesel and gasoline engine exhausts and some nitroarenes (5-12 June 2012, IARC, Lyon, France)
  Preliminary list of agents to be reviewed
  Call for Data (closes 5 May 2012)
  Call for Experts (closes 31 Aug 2011)
  Request for Observer Status (opens 5 Oct 2011, closes 5 Feb 2012)
  WHO Declaration of Interests for this volume

See Upcoming Meetings - IARC Monographs website
IARC Monographs - Questions and Answers
31/05/2011 -
Dr Christopher Wild, IARC Director, answers a few questions on the IARC Monographs.
The answers are available in Windows Media Movie (WMV) and DVD quality for media.

Please click here
IARC Press Release N° 208
31/05/2011 -
IARC classifies Radiofrequency Electromagnetic Fields as possibly carcinogenic to humans.
Listen Virtual press conference audio file
Watch UNIFeed footage

Read Press Release
Monograph Meeting - Volume 102
24/05/2011 -
Dr Christopher Wild, Director, IARC, opens Monograph meeting on Non-Ionizing Radiation, Part II: Radiofrequency Electromagnetic Fields [includes mobile telephones]

Listen to Podcast , Read Introduction to the IARC Monographs Volume 102
IARC Publications - PDFs online - IARC Monographs - Volume 100 - Part A : Pharmaceuticals and Part B: Biological Agents
23/05/2011 -
The IARC Monographs, Volume 100: A review of Human Carcinogens - Part A: Pharmaceuticals and Part B: Biological Agents are now available in PDF format.
These electronic versions of Volume 100A and Volume 100B include hyperlinks that enable you to jump from:
   -  the text to the quoted reference or table
   -  the PMID of a reference to the relevant PubMed page
   -  the doi of a reference to the pdf of the article

Download , Order at WHOPress
5th p63/p73 Workshop - Registration and Abstract Submission
20/05/2011 -
The website of the 5th p63/p73 Workshop (12-14 September 2011, IARC, Lyon, France) is now open for registration and abstract submission.
This fifth workshop will provide a forum for researchers involved in research on p63/p73 and for all those interested in their biological or pathological significance.

Please visit website here
IARC Scientific Publications - Cancer Survival in Africa, Asia, the Caribbean and Central America (SurvCan)
10/05/2011 -
The World Health Organization’s International Agency for Research on Cancer (IARC) announces the publication of cancer survival data from 27 population-based cancer registries in 14 countries in 'Cancer Survival in Africa, Asia, the Caribbean and Central America,' a follow-up to the 1999 volume entitled Cancer Survival in Developing Countries. This new volume, also available in electronic form on the internet (http://survcan.iarc.fr), includes survival data for the years 1990–2000 and represents data from three times as many cancer registries as in the earlier volume, and a vast increase in the number of cancer sites and patients.
Read more
International Incidence of Childhood Cancer (IICC) - Volume 3 - Call for Data
09/05/2011 -
IARC announces a Call for Data for the third volume of the IARC Scientific Publication entitled International Incidence of Childhood Cancer (IICC). This project, conducted in collaboration with the International Association of Cancer Registries (IACR), aims to disseminate the most recent data on cancer incidence in children and adolescents collected in population-based cancer registries around the world. Its publication is scheduled for 2012.
See the IICC-3 web-site for more information
Postdoctoral Opportunities
09/05/2011 -
Call for applications for a postdoctoral opportunity in the Section of Genetics.
Read more
IARC Day 2011
04/05/2011 -
The traditional IARC Day will take place Wednesday, 11th May 2011 at the IARC headquarters.
See Programme
First global ministerial conference on healthy lifestyles and noncommunicable disease control
03/05/2011 -
First Global Ministerial Conference on Healthy Lifestyles and Noncommunicable Disease Control
28-29 April 2011, Moscow, the Russian Federation
The conference is a key milestone in the international campaign to curb the impacts of cancers, cardiovascular diseases, diabetes and chronic lung diseases. It is jointly organized by the Russian Federation and WHO, and takes place on 28-29 April 2011, Moscow, the Russian Federation.
Video of Christopher Wild's presentation, Director, IARC and Member of the International Steering Committee of the Conference, is available now.
Watch Webcast (advance Seek Bar to 16:53:39) , Visit the conference website for more information
IARC Monographs - List of Classifications
18/04/2011 -
The list of agents classified by the IARC Monographs has been updated. It now includes all evaluations up to volume 101.

See List of Classifications
The Lancet Oncology
18/04/2011 -
The Lancet Oncology, Volume 12, Issue 4, Pages 328 - 329, April 2011
doi:10.1016/S1470-2045(11)70088-2
Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproduct
Grosse Y., Baan R., Secretan-Lauby B., El Ghissassi F., Bouvard V., Benbrahim-Tallaa T., Guha N., Islami F., Galichet L., Straif K., on behalf of the WHO IARC Monograph Working Group

Full Text
IARC Monographs Volume 104 - Upcoming Meetings
17/04/2011 -
IARC Monographs Volume 104 - Polyomaviruses (SV40, BK, JC, and Merkel cell viruses) and malaria
7-14 Feb 2012 - IARC, Lyon, France

See details
IARC Training Courses - Statistical Practice in Epidemiology with R
11/04/2011 -
Statistical Practice in Epidemiology with R
5 to 9 September 2011
IARC, Lyon, France
Deadline for applications is: 21 May 2011

Read more
Launch of AGRICOH website - International Consortium of Agricultural Cohort Studies
06/04/2011 -
The International Agency for Research on Cancer (IARC) is the coordinating centre for a recently-formed consortium of cohort studies investigating health outcomes in association with a wide range of agricultural exposures. This consortium, named AGRICOH, includes 19 agricultural population cohort studies and three general population cohorts with a significant proportion of farmers. This consortium arose from a 2006 meeting at the National Cancer Institute in the USA, and it was formalized as a consortium at IARC in Lyon, France in October of 2010.

The aim of AGRICOH is to explore opportunities for data harmonization and pooling, and support the study of disease-agricultural exposure associations with larger sample sizes; this is particularly important when studying uncommon exposures such as application of particular pesticide products or rare diseases such as ovarian or testicular cancer, for example.

A dedicated website, http://agricoh.iarc.fr, presents AGRICOH to the scientific community through its public interface, including objectives, descriptions of the cohorts, news about the consortium, and other information. The site will also offer the consortium an electronic work platform through its password-protected area.

Link to AGRICOH website
EurocanPlatform project website launched
05/04/2011 -
EurocanPlatform is an European Commission funded project that brings together 28 cancer research centres, to coordinate research activities, share infrastructures and create a collaborative network within the European Union to advance cancer research and treatment. IARC is a partner in this project, responsible primarily for work in the area of cancer prevention. Some of the other proposed activities include early detection, biomarker discovery, optimization of cancer registration and biobanking.
Link to EurocanPlatform website
The Asturias Declaration - A new call to action on Environmental and Occupational Cancer Prevention
23/03/2011 -
WHO has organized the “International Conference on Environmental and Occupational Determinants of Cancer: Interventions for Primary Prevention”, held 17-18 March 2011 in Asturias (Avilés, Gijón), Spain. IARC scientists worked closely together with colleagues at WHO to develop the scientific programme and to draft the Asturias declaration, a call for action.

Read more
IARC featured in International Innovation Health
21/03/2011 -
International Innovation, the global science, technology and research dissemination resource, has produced a special issue of International Innovation Health focusing on the upcoming BioVision Life Sciences Forum, a biennial international meeting for scientists, decision-makers and stakeholders, being held March 27-29 at Cité Internationale in Lyon. This special issue includes a 3-page interview with IARC Director Christopher Wild, who discusses the Agency's international approach, its global reach, and its goals for the future.

The issue is online here, the IARC article begins on page 106.
2009 Senior Visiting Scientist Award and IARC Medal of Honour - Professor Julian Peto
17/03/2011 -
The Infections and Cancer Epidemiology Group was proud to host the IARC Medal of Honour and 2009 Senior Visiting Scientist Awardee, Professor Julian Peto, for six months last year. Professor Peto, from the Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, is one of the most influential epidemiologists of his generation.
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IARC research shows epigenetic mechanisms of breast cancer stem-cells, potentially paving the way for targeted therapy
02/03/2011 -
Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells
Epigenetics. Volume 6, Issue 4 -   April 2011
H Hernández-Vargas, M Ouzounova, F Le Calvez-Kelm, M-P Lambert, S McKay-Chopin, S V. Tavtigian, A Puisieux, C Matar and Z Herceg

Increasing evidence suggests that breast tumours include a subpopulation of cancer cells with stem cell characteristics. In this study, we used genome-wide DNA methylation profiling and quantitative gene expression to characterize the epigenetic mechanisms that regulate the developmental pathways in these putative breast cancer stem cells.
 
Our results revealed that these cells show activation of a specific evolutionary-conserved signalling pathway (the Jak-STAT pathway), indicating that Jak-STAT activation may represent a characteristic of breast cancer stem cells. These findings support the idea that epigenetic mechanisms control the expression of cancer stem-like pathways, and therefore establish and maintain the defining properties of cancer stem cells. Thus our results have potential implications in developing targeted therapy for breast cancer.
Read Article
Global Cancer Statistics
16/02/2011 -
A Jemal, F Bray, MM Center, J Ferlay, E Ward, D Forman
Global Cancer Statistics
CA Cancer J Clin. 2011 Feb 4. [Epub ahead of print]

The global burden of cancer is increasing, and patterns of incidence and mortality are changing rapidly as people in lower-resource countries adopt cancer-associated lifestyle choices such as tobacco use and "westernized" diet. What is the extent of these changes, and what are their implications? Based on IARC's worldwide standard set of cancer incidence and mortality estimates, GLOBOCAN 2008, a new publication in CA: A Cancer Journal for Clinicians entitled "Global Cancer Statistics" aims to quantify the scope of the problem-- and its prevention-based solutions-- for the practicing clinician.

In collaboration with IARC’s Cancer Information Section, the American Cancer Society published the Second edition of Global Cancer Facts and Figures

Read Article , Read Global Cancer Facts and Figures
PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)
14/02/2011 -
Major EU project to tackle complications of cancer treatment in childhood and adolescence

Survival of patients affected by cancer in childhood and adolescence has improved substantially, such that up to 80% of these patients survive 5 years after their diagnosis. However, the treatments leading to these favourable results often lead to variable long-term side-effects in the survivors, including physical disability, cardiovascular or kidney insufficiency, hormone imbalances affecting fertility or cognitive function, and others.
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World Cancer Day 2011: New physical activity guidance can help prevent breast, colon cancers
04/02/2011 -
4 February, 2011 | Geneva, Lyon -- The world can do more to stop people suffering and dying from cancer, such as embracing measures, including new physical activity guidance, that can prevent one-third of the annual 7.6 million cancer deaths, as well as providing better services for early detection and treatment of cancer.

Read Press Release and Listen to Audio materials
European Guidelines for Quality Assurance in Colorectal Cancer Screening
03/02/2011 -
Segnan N, Patnick J, & von Karsa L (eds.)
European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis - First Edition (2010)
European Commission, Publications Office of the European Union, Luxembourg.

Watch EU Technical Briefing on CRC Guidelines

Download CRC Guidelines , Read IARC Press Release 204
Launch of the European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis
02/02/2011 -
Following the success of the EU Guidelines for quality assurance in breast and cervical cancer screening, the first edition of the “European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis” has been produced in an international collaborative project coordinated by IARC involving a multidisciplinary group of more than 90 experts from 21 EU Member States and 11 other countries around the World.

The official launch will be at the European Commission in Brussels on Thursday 3 February.
The press conference will take place at around 12h20, just after the Midday Press briefing. It will be web-streamed and can be followed live on the Europe by Satellite (EBS) website by clicking on “EC Midday press briefing LIVE”

Further information will be available on February 3rd from 12h00 onwards on the Commission's website in the form of a press release that contains a link to the electronic version of the Guidelines.

Segnan N, Patnick J, & von Karsa L (eds.) European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis - First Edition (2010) European Commission, Publications Office of the European Union, Luxembourg


Visit EBC , European Commission's websites
Visit on 4 February of Mrs Nora Berra, Secrétaire d'Etat chargée de la Santé from the French Ministry of Health
02/02/2011 -
On the occasion of the World Cancer Day (4 February 2011), IARC is proud to welcome Mrs Nora Berra, Secrétaire d’Etat auprès du Ministre du Travail, de l’Emploi et de la Santé, chargée de la Santé.


Read Biography , Agenda (Portail du Gouvernement)
IARC Publications - IARC Handbook of Cancer Prevention - Volume 6
01/02/2011 -
IARC Handbook of Cancer Prevention - Volume 6
Weight Control and Physical Activity is now available in PDF format.


Download here
REMINDER - IARC Summer School in Cancer Epidemiology 2011
10/01/2011 -
Summer School in Cancer Epidemiology
20 June to 8 July 2011
The deadline for applications is 17 January 2011

Download Course Schedule and Forms
Scientific papers on GLOBOCAN 2008 and the Cancer Incidence in Five Continents (CI5) databases published in the IJC
06/01/2011 -
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
J Ferlay, HR Shin, F Bray, D Forman, C Mathers, DM Parkin
Int J Cancer. 2010; 127 (12): 2893-2917

Fifty years of cancer incidence: CI5 I-IX
DM Parkin, J Ferlay, MP Curado, F Bray, B Edwards, HR Shin, D Forman
Int J Cancer. 2010; 127 (12): 2918-2927

Read articles GLOBOCAN 2008 , CI5 I-IX database