Media Centre - IARC NEWS

2017

IARC Monographs Volume 119: Evaluation of some chemicals that cause tumours of the urinary tract in rodents
28/06/2017 -
A Working Group of 21 scientists from 9 countries met at the International Agency for Research on Cancer (IARC) on 6–13 June 2017 to evaluate the carcinogenicity of 1‐tert‐butoxypropan‐2‐ol, β‐myrcene, furfuryl alcohol, melamine, pyridine, tetrahydrofuran, and vinylidene chloride. A summary of the evaluations has now been published in The Lancet Oncology. The detailed assessments will be published as Volume 119 of the IARC Monographs.

Grosse Y, Loomis D, Guyton KZ, El Ghissassi F, Bouvard V, Benbrahim L, et al.
Some chemicals that cause tumours of the urinary tract in rodents
Lancet Oncol, Published online 27 June 2017; http://dx.doi.org/10.1016/S1470-2045(17)30505-3

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Benchmarking life expectancy and cancer mortality: global comparison with cardiovascular disease 1981–2010
22/06/2017 -
A new study coordinated by the International Agency for Research on Cancer (IARC) and published today in the British Medical Journal (BMJ) assesses the global impact of cancer compared with cardiovascular disease (CVD) on changes in life expectancy. Using data from 52 populations included in the World Health Organization Mortality Database over the period 1981–2010, the study shows that declining cancer mortality rates were responsible for up to 20% of the overall gains in life expectancy at ages 40–84 years. Declining CVD mortality rates had the greatest impact and were responsible for more than 50% of the overall gains experienced.

Cao B, Bray F, Beltrán-Sánchez H, Ginsburg O, Soneji S, Soerjomataram I
Benchmarking life expectancy and cancer mortality: global comparison with cardiovascular disease 1981–2010
BMJ. Published online 22 June 2017; http://dx.doi.org/10.1136/bmj.j2765
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
19/06/2017 -
A new large-scale association analysis coordinated by scientists from the International Agency for Research on Cancer (IARC) and published in Nature Genetics identifies new lung cancer susceptibility loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer. In this analysis, 14 803 cases and 12 262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29 266 cases and 56 450 controls.

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, et al.
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Nat Genet. Published online 12 June 2017;
http://dx.doi.org/10.1038/ng.3892

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IARC and the National Cancer Institute of Thailand sign new agreement
16/06/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the signature of a new Letter of Agreement with the National Cancer Institute of Thailand, as part of IARC’s Global Initiative for Cancer Registry Development (GICR), to establish an IARC/GICR Collaborating Centre in Bangkok. The areas of focus of the new Collaborating Centre will include the delivery of tailored training courses in East Asia and the development of networks to promote population-based cancer registration and improve the quality and use of registry data in the region.
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IARC welcomes the adoption of the new cancer resolution by the World Health Assembly
30/05/2017 -
Today, governments from around the world adopted a new cancer resolution at the Seventieth World Health Assembly, in Geneva, Switzerland. This resolution complements the World Health Organization (WHO) Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013–2020. It points to many cancer control measures, including health promotion, reducing exposure to cancer risk factors, and improving access to early diagnosis and treatment. Prevention and early detection have a key role to play, in particular in low- and middle-income countries.
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Jane Mitchell (1952–2017)
29/05/2017 -
The International Agency for Research on Cancer (IARC) is saddened by the passing of Jane Mitchell, a long-time IARC staff member, who died on Wednesday 24 May 2017. Our deepest sympathy is with Jane’s family.

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IARC strengthens cancer control partnership with Japan
19/05/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the signature of a new Memorandum of Understanding with the National Cancer Center Japan to further promote collaboration on cancer research and control in the region. The agreement falls within IARC's Global Initiative for Cancer Registry Development (GICR), to establish an IARC/GICR Collaborating Centre with a specific focus on supporting the development of analytical capacity and descriptive epidemiological research using population-based cancer registry data in East Asia.

Visit the GICR website , Visit the National Cancer Center Japan website
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
19/05/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on Some Nanomaterials and Some Fibres is now available online. The volume includes monographs on carbon nanotubes, fluoro-edenite, and silicon carbide.

Visit the Volume 111 webpage
Launch of the International Cancer Survival Benchmarking website
16/05/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the launch of the International Cancer Survival Benchmarking website. Incorporating the most up-to-date population-based cancer survival data available, this new platform will provide a comprehensive view of cancer survival estimates, alongside incidence and mortality, in high-income countries and countries in transition. Aimed at researchers, policy-makers, and public health specialists, the website brings together three international landmark projects: SURVMARK-2, SURVCAN-3, and SURVPOOL, in order to move towards better outcomes after cancer diagnosis for all.
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Launch of new guidelines for biobanks dedicated to cancer research
15/05/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the publication of new guidelines and recommendations for biobanks. The publication, Common Minimum Technical Standards and Protocols for Biobanks Dedicated to Cancer Research, provides essential guidance for biobanks not only in high-income countries but also in low- and middle-income countries. The recommendations are based on validated and/or evidence-based guidelines.
Read more , See IARC Technical Publication 44
A global cancer surveillance framework within noncommunicable disease surveillance: making the case for population-based cancer registries
08/05/2017 -
A new study by researchers from the International Agency for Research on Cancer (IARC) presents a global surveillance framework for monitoring the core components of cancer control, illustrating both the unique role of cancer registries and commonalities with the surveillance of other noncommunicable diseases.

Piñeros M, Znaor A, Mery L, Bray F
A global cancer surveillance framework within noncommunicable disease surveillance: making the case for population-based cancer registries
Epidemiologic Reviews. Published online 2 May 2017
https://doi.org/10.1093/epirev/mxx003

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Obesity and high insulin levels: two important risk factors for pancreatic cancer
05/05/2017 -
A new large-scale genetic research study led by researchers from the International Agency for Research on Cancer (IARC) has identified elevated body mass index (BMI) and increased fasting insulin levels as causal risk factors for pancreatic cancer. The researchers also provided intriguing new evidence on the mechanistic pathways that may play a role, in particular for insulin-related pathways. Pancreatic cancer is one of the most lethal cancers, with 5-year survival rates of about 5%. Therefore, the identification of modifiable risk factors can play a critical role in informing preventive measures.

Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, et al.
The role of obesity, type 2 diabetes, and metabolic factors in pancreatic cancer: a Mendelian randomization study
J Natl Cancer Inst. Published online 28 April 2017;
http://dx.doi.org/10.1093/jnci/djx012

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IARC and PAHO host meeting to develop cancer prevention messages for Latin America
28/04/2017 -
IARC and the Pan American Health Organization (PAHO) jointly hosted a meeting in Washington, DC, USA, on 24 and 25 April with representatives from cancer and public health institutions in Latin America and the Caribbean to explore the possibility of developing an evidence-based set of cancer prevention messages targeted to the general population of the region.

See PAHO website

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Latest data show a global increase of 13% in childhood cancer incidence over two decades
12/04/2017 -
An international study coordinated by the International Agency for Research on Cancer (IARC) and published today in The Lancet Oncology shows that in 2001–2010, childhood cancer was 13% more common than in the 1980s, reaching an annual incidence rate of 140 per million children aged 0–14 years worldwide.

Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, Hesseling P, Shin HY, Stiller CA, and the IICC-3 contributors.
International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol. Published online 11 April 2017.
http://dx.doi.org/10.1016/S1470-2045(17)30186-9

Read article , IARC Press Release 251
IARC Monographs Volume 118: Evaluation of welding, welding fumes, and some related chemicals
11/04/2017 -
A Working Group of 17 scientists from 10 countries met at the International Agency for Research on Cancer (IARC) on 21–28 March 2017 to evaluate the carcinogenicity of welding, molybdenum trioxide, and indium tin oxide. A summary of the evaluations has now been published in The Lancet Oncology. The detailed assessments will be published as Volume 118 of the IARC Monographs.

Guha N, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, et al.
Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide
Lancet Oncol, Published online 10 April 2017;
http://dx.doi.org/10.1016/S1470-2045(17)30255-3

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Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
05/04/2017 -
Human papillomavirus (HPV) infection is an emerging risk factor associated with head and neck cancer. A new study led by the Epigenetics Group at the International Agency for Research on Cancer (IARC) identified a novel epigenetic signature of HPV infection in head and neck squamous cell carcinomas (HNSCCs). This signature, which is independent of the anatomical site, was shown to be a better predictor of survival compared with HPV status determined by viral gene expression, and thus could be leveraged for improved prediction of survival in HNSCCs.
Degli Esposti D, Sklias A, Lima SC, Beghelli-de la Forest Divonne S, Cahais V, Fernandez-Jimenez N, et al.
Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
Genome Medicine. Published online 5 April 2017
http://dx.doi.org/10.1186/s13073-017-0419-z

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IARC Monographs Meetings - Volume 121: Styrene, Styrene-7,8-oxide, and Quinoline
03/04/2017 -
IARC Monographs Volume 121: Styrene, Styrene-7,8-oxide, and Quinoline
20-27 March 2018
Lyon, France

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IARC Monographs Meetings - Volume 118: Welding, Welding Fumes, and Some Related Chemicals
20/03/2017 -
IARC Monographs Volume 118: Welding, Welding Fumes, and Some Related Chemicals
21-28 March 2017
Lyon, France

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Launch of World Indigenous Cancer Conference (WICC) Network
16/03/2017 -
The International Agency for Research on Cancer (IARC) is proud to be a partner in the WICC Network, which is hosted by Menzies School of Health Research, Australia. The WICC Network is dedicated to improving cancer outcomes for Indigenous peoples around the world. It was established to continue research collaboration after the World Indigenous Cancer Conference (WICC), which was held in Brisbane, Australia, in 2016.
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Glyphosate not classified as a carcinogen by ECHA
15/03/2017 -
The International Agency for Research on Cancer (IARC) is aware that the Committee for Risk Assessment of the European Chemicals Agency (ECHA) has concluded that the available scientific evidence did not meet the criteria of the “Classification, Labelling and Packaging” (CLP) Regulation required to classify glyphosate as a carcinogen or as genotoxic.

The international experts composing the IARC Monograph Working Group, which evaluated glyphosate in March 2015, concluded that glyphosate is “probably carcinogenic to humans” based on the publicly available scientific evidence on epidemiology, animal carcinogenicity, and carcinogenic mechanisms, using the methodology described in detail in the IARC Monographs preamble.

The IARC evaluation of glyphosate is not affected by the ECHA review. IARC does not comment on the expertise, methodology, or conclusions of other national or international committees.
Read more , Q&A on Glyphosate
IARC Handbooks of Cancer Prevention Meetings - Volume 17 - Reminder: Deadline for call for experts: 14 March 2017
08/03/2017 -
IARC Handbooks of Cancer Prevention
Volume 17: Colorectal cancer screening
14-21 November 2017
IARC, Lyon, France

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DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
01/03/2017 -
A new study led by the International Agency for Research on Cancer (IARC) evaluates the link between the DNA methylation-based marker of ageing, known as the “epigenetic clock”, and breast cancer risk. The study, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, a large prospective study conducted in 23 centres across 10 European countries, shows that an accelerated epigenetic clock is associated with susceptibility to postmenopausal breast cancer.

Ambatipudi S, Horvath S, Perrier F, Cuenin C, Hernandez-Vargas H, Le Calvez-Kelm F, et al.
DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
Eur J Cancer, Published online 1 March 2017
http://dx.doi.org/10.1016/j.ejca.2017.01.014

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Energy balance and obesity: what are the main drivers?
28/02/2017 -
The International Agency for Research on Cancer (IARC) convened a Working Group of international experts in December 2015 to review the evidence regarding energy balance and obesity, with a focus on low- and middle-income countries. A summary of the topics addressed and the conclusions and recommendations of the Working Group has been published in Cancer Causes & Control.

Romieu I, Dossus L, Barquera S, Blottière HM, Franks PW, Gunter M, et al.; IARC Working Group on Energy Balance and Obesity
Energy balance and obesity: what are the main drivers?
Cancer Causes Control. Published online 17 February 2017
http://dx.doi.org/10.1007/s10552-017-0869-z

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IARC Junior Investigator Awards 2017
24/02/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the recipients of the IARC Junior Investigator Awards for 2017.
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IARC Postdoctoral Opportunities - Section of Genetics/Genetic Epidemiology Group
17/02/2017 -
A postdoctoral opportunity is immediately available within the Genetic Epidemiology Group to work on multidisciplinary cancer studies. Successful candidates should have a strong background in cancer genomics and/or epidemiology and/or biostatistics, as well as a good command of English.
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Release of latest data on incidence of childhood cancer
15/02/2017 -
The International Agency for Research on Cancer (IARC) is releasing the latest data on the incidence of childhood cancer across the world to mark International Childhood Cancer Day. The results, which are part of the third volume of the International Incidence of Childhood Cancer (IICC) project, are based on collaboration of more than 300 high-quality registries in 82 countries, departments, and territories on five continents. Tabulated data on more than 770 000 neoplasms diagnosed in patients younger than 20 years are now accessible online, with statistics presented for the diagnostic groups relevant to childhood cancer.
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IARC researchers part of team awarded Grand Challenge grant
10/02/2017 -
The International Agency for Research on Cancer (IARC) is proud to announce that IARC researchers are part of a team that has been awarded a grant of up to £20 million as part of the Grand Challenge, facilitated by Cancer Research UK. The research project, "Mutographs of Cancer: Discovering the causes of cancer through mutational signatures", is a joint initiative that aims to better define what causes DNA damage and how it leads to cancer. The project is a response to Grand Challenge 3: "Discover how unusual patterns of mutation are induced by different cancer-causing events".
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Implementation of cancer screening in the European Union (2017)
09/02/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the publication of Cancer Screening in the European Union (2017): Report on the Implementation of the Council Recommendation on Cancer Screening. This is the second report on the status of implementation of cancer screening programmes in the European Union since the recommendation from the European Council in 2003. The report was prepared by IARC in collaboration with the Piedmont Reference Center for Epidemiology and Cancer Prevention (CPO Piemonte), Italy, and the Cancer Society of Finland (CSF), Mass Screening Registry, Finland.
View the report , Read the EC press release
World Cancer Day 2017
03/02/2017 -
Every year on World Cancer Day (4 February), the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) support the Union for International Cancer Control (UICC) in promoting ways to reduce the global burden of cancer. On 3 February 2017, IARC is hosting the 4th IARC Cancer and Society Lecture, featuring Karin Holm , who will present a talk entitled "Patient Power for Better Research: I Can, We Can".

4th IARC Cancer and Society lecture
Friday 3 February 2017 at 11:00 am

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Affordable vaccines key to scale up HPV vaccination and prevent thousands of avoidable cervical cancers
02/02/2017 -
Every year, cervical cancer kills more than 250 000 women, and 85% of these deaths occur in low- and middle-income countries. Cervical cancer is the fourth most common cancer in women worldwide, but most of these deaths could be prevented with adequate prevention measures, such as vaccination of girls against human papillomavirus (HPV) and screening programmes to detect and treat precancerous lesions.
Read IARC Press Release 250 , Watch videos
Launch of Exposome-Explorer website
31/01/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the launch of the Exposome-Explorer website. Exposome-Explorer is a manually curated database of biomarkers of exposure to dietary and environmental factors. The database was developed at IARC in collaboration with the University of Alberta, Canada. The website should be particularly useful for researchers wishing to select panels of biomarkers that can be used in biomonitoring studies or in exposome-wide association studies, thereby allowing them to better understand the etiology of chronic diseases.
Visit the website
IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides
27/01/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on Some Organophosphate Insecticides and Herbicides is now available online. The volume includes monographs on diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos.
Visit the Volume 112 webpage
IARC Postdoctoral Opportunities - Section of Cancer Surveillance
25/01/2017 -
A postdoctoral opportunity is immediately available within the Section of Cancer Surveillance to participate in the SURVMARK-2 project (A Comprehensive Approach to International Cancer Survival Benchmarking).

Deadline: 12 February 2017

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WHO Classification of Head and Neck Tumours
23/01/2017 -
The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome.

WHO Classification of Head and Neck Tumours
WHO/IARC Classification of Tumours, 4th Edition, Volume 9
Edited by El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ

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Launch of the SABC website
12/01/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce the launch of the South Africa Breast Cancer (SABC) study website. The SABC study is a population-based case–control study set up at the Baragwanath Hospital in Soweto, South Africa, to study the etiology of breast cancer in black South African women. The study is very important because it is among the first to study specific factors, including lifestyle and dietary habits, in the black South African population that may be associated with specific subtypes of breast cancer. The aim of the study is to advance the prevention and management of breast cancer in black women in South Africa through a better understanding of the molecular, pathological, and risk factor patterns.
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Dominique Hornez (1954–2017)
10/01/2017 -
The International Agency for Research on Cancer (IARC) is saddened by the passing of Dominique Hornez, a long-time IARC staff member, who died on Sunday 8 January 2017 in Lyon. Our deepest sympathy is with his son, Florent.
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IARC scientist receives Rosalind E. Franklin Award
10/01/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce that Dr Silvia Franceschi, Special Advisor on Noncommunicable Diseases and Head of the Infections and Cancer Epidemiology Group in the IARC Section of Infections, is the 2017 recipient of the Rosalind E. Franklin Award, presented today by the United States National Cancer Institute. The prize honours the commitment of women in cancer research and is given in tribute to Dr Franklin, who played a critical role in the discovery of the DNA double helix. On the occasion of the award, Dr Franceschi is presenting a lecture on "Global burden of cancer attributable to infections (with focus on HPV)".
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IARC Postdoctoral Opportunities - Section of Mechanisms of Carcinogenesis/Epigenetics Group
09/01/2017 -
Two postdoctoral opportunities: "Postdoctoral opportunity in epigenetic mechanisms and cancer development" and "Postdoctoral opportunity in epigenetics and breast cancer" are immediately available within the Epigenetics Group to study epigenetics and cancer.

Deadline: 31 January 2017

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IARC Monographs Volume 110: Some Chemicals Used as Solvents and in Polymer Manufacture
09/01/2017 -
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on Some Chemicals Used as Solvents and in Polymer Manufacture is now available online.
Visit the Volume 110 webpage