You are here: Home

Search Result (493 REFERENCES)

2005

Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)

J Natl Cancer Inst; 2005; 97(10): 755-765
Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC)

Lahmann P.H., Schulz M., Hoffmann K., Boeing H., Tjonneland A., Olsen A., Overvad K., Key T.J., Allen N.E., Khaw K.T., Bingham S., Berglund G., Wirfalt E., Berrino F., Krogh V., Trichopoulou A., Lagiou P., Trichopoulos D., Kaaks R., Riboli E.

Br J Cancer; 2005; 93(5): 582-589

Abstract as provided by PubMed

We examined prospectively the association between weight change during adulthood and breast cancer risk, using data on 1358 incident cases that developed during 5.8 years of follow-up among 40,429 premenopausal and 57,923 postmenopausal women from six European countries, taking part in the European prospective investigation into cancer and nutrition study. Multivariate Cox regression models were used to calculate hazard ratios according to weight change (kg), defined as the weight difference between age at enrollment and age 20 adjusted for other risk factors. Changes in weight were not associated with premenopausal breast cancer risk. In postmenopausal women, weight gain was positively associated with breast cancer risk only among noncurrent hormone replacement therapy (HRT) users (P-trend < or = 0.0002). Compared to women with a stable weight (+/-2 kg), the relative risk for women who gained 15-20 kg was 1.50 (95% confidence interval (CI) 1.06-2.13). The pooled RR per weight gain increment of 5 kg was 1.08 (95% CI 1.04-1.12). Weight gain was not associated with breast cancer risk in current HRT users, although, overall, these women experienced a much higher risk of breast cancer compared with nonusers. Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones

Meat and fish consumption, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)

J Natl Cancer Inst; 2005; 97(12): 906-916
Re: Meat, fish, and colorectal cancer risk: The European prospective investigation into cancer and nutrition - Reply

Norat T., Bingham S., Riboli E.

J Natl Cancer Inst; 2005; 97(23): 1788-1789
DNA adducts and lung cancer risk: a prospective study

Peluso M., Munnia Armelle, Hoek Gerard, Krzyzanowski Michal, Veglia Fabrizio, Airoldi Luisa, Autrup Herman, Dunning Alison, Garte Seymour, Hainaut Pierre, Malaveille Christian, Gormally Emmanuelle, Matullo Giuseppe, Overvad Kim, Raaschou-Nielsen Ole, Clavel-Chapelon Francoise, Linseisen Jacob, Boeing Heiner, Trichopoulou Antonia, Trichopoulos Dimitrios, Kaladidi Anna, Palli Domenico, Krogh Vittorio, Tumino Rosario, Panico Salvatore, Bueno-De-Mesquita H.Bas, Peeters Petra H., Kumle Merethe, Gonzalez Carlos A., Martinez Carmen, Dorronsoro Miren, Barricarte Aurelio, Navarro Carmen, Quiros J.Ramon, Berglund Goran, Janzon Lars, Jarvholm Bengt, Day Nicholas E., Key Tim J., Saracci Rodolfo, Kaaks Rudolf, Riboli Elio, Vineis Paolo

Cancer Res; 2005; 65(17): 8042-8048

Abstract as provided by PubMed

Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using 32P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O3 indicates a possible role for photochemical smog in determining DNA damage

Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition

Schulz M., Lahmann P.H., Boeing H., Hoffmann K., Allen N., Key T.J., Bingham S., Wirfalt E., Berglund G., Lundin E., Hallmans G., Lukanova A., Martinez Garcia C., Gonzalez C.A., Tormo M.J., Quiros J.R., Ardanaz E., Larranaga N., Lund E., Gram I.T., Skeie G., Peeters P.H., Van Gils C.H., Bueno-de-Mesquita H.B., Buchner F.L., Pasanisi P., Galasso R., Palli D., Tumino R., Vineis P., Trichopoulou A., Kalapothaki V., Trichopoulos D., Chang-Claude J., Linseisen J., Boutron-Ruault M.C., Touillaud M., Clavel-Chapelon F., Olsen A., Tjonneland A., Overvad K., Tetsche M., Jenab M., Norat T., Kaaks R., Riboli E.

Cancer Epidemiol Biomarkers Prev; 2005; 14(11): 2531-2535

Abstract as provided by PubMed

OBJECTIVE: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. METHODS: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. RESULTS: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. CONCLUSION: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation

2004

Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Public Health Nutr; 2004; 7(6): 713-722
Diet and cancer - the European Prospective Investigation into Cancer and Nutrition

Bingham S., Riboli E.

Nat Rev Cancer; 2004; 4(3): 206-215
Association of nut and seed intake with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Cancer Epidemiol Biomarkers Prev; 2004; 13(10): 1595-1603
Fruit and vegetables and prostate cancer: no association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Int J Cancer; 2004; 109(1): 119-124
Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Int J Cancer; 2004; 111(5): 762-771
Fruits and vegetables and lung cancer: findings from the European Prospective Investigation into Cancer and Nutrition

Int J Cancer; 2004; 108(2): 269-276
Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Ugeskr Laeger; 2004; 166(25): 2458-2460

2003

Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study

Lancet; 2003; 361(9368): 1496-1501
Relationship between plasma fatty acid composition and diet over previous years in the Italian centers of the European Prospective Investigation into Cancer and Nutrition (EPIC)

Fusconi E., Pala V., Riboli E., Vineis P., Sacerdote C., Del Pezzo M., Santucci de Magistris M., Palli D., Masala G., Sieri S., Foggetti C.E., Giurdanella M.C., Tumino R., Krogh V.

Tumori; 2003; 89(6): 624-635

Abstract as provided by PubMed

Fatty acid levels in plasma phospholipids were related to food intake over the previous year as estimated by semiquantitative food frequency questionnaires compiled by 280 men and 246 women from the EPIC centers of Varese, Turin, Florence and Ragusa (Italy). Fatty acid content was determined by gas chromatography and analyzed in relation to age, sex and center. The most important finding was that plasma monounsaturated fatty acid levels, mainly oleic acid, were associated with olive oil consumption (r = 0.28 men, r = 0.19 women, both P <0.01). To our knowledge, this is the first time that these non-essential plasma fatty acids have been related to their dietary source in a population eating a varied and freely chosen diet. We confirmed that long-chain n-3 fatty acids in plasma phospholipids are associated with fish consumption and that odd chain 15 : 0 and 17 : 0 fatty acid levels are associated with dairy products and pizza-with-mozzarella consumption. N-6 polyunsaturated fatty acid levels reflected dietary intake of seed oils, mayonnaise and biscuits. Alcohol intake was positively associated with palmitic and palmitoleic acid and negatively associated with linoleic acid. These associations suggest indirect relations between alcohol consumption and other features of diet, and also that ethanol has an effect on fat metabolism. We found numerous indirect relationships (ie, not due to dietary consumption of food sources of the fatty acids) between plasma fatty acids and diet, which we propose as due to the influence of complex life-style factors

Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Int J Cancer; 2003; 107(4): 629-634
Quantity and quality of dietary fat, carbohydrate, and fiber intake in the German EPIC cohorts

Linseisen J., Schulze M.B., Saadatian-Elahi M., Kroke A., Miller A.B., Boeing H.

Ann Nutr Metab; 2003; 47(1): 37-46

Abstract as provided by PubMed

AIM: This evaluation aims to describe the quantity and quality of dietary fat, carbohydrate and fiber intake in both German cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Estimates are based on standardized computer-guided 24-hour dietary recalls from 1,078 women and 1,013 men in Heidelberg and 898 women and 1,032 men in Potsdam. In a subsample, plasma phospholipid (PL) fatty acids were analyzed as well. RESULTS: Adjusted mean dietary intake estimates demonstrated that the contribution of fat as well as n-6 and n-3 polyunsaturated fatty acids (PUFA) to the total daily energy intake was higher in both women and men of EPIC-Potsdam compared to EPIC-Heidelberg. Surprisingly, the dietary n-6/n-3 PUFA ratio was lower in the Potsdam cohort. These results were confirmed by means of the PL fatty acid pattern. Besides the higher contribution of polysaccharides to total energy intake in EPIC-Heidelberg, women of the Heidelberg cohort revealed a significantly lower contribution of mono- and disaccharides (sucrose) to total energy intake. Although total fiber intake data were similar in both cohorts, analysis by food groups showed differences in dietary fiber intake originating from the food groups cereals, fruits and potatoes. CONCLUSION: The results demonstrate distinct differences in the dietary fat, carbohydrate and fiber intake between both German EPIC cohorts, which contribute to the exposure variation in the whole of EPIC

Group level validation of protein intakes estimated by 24-hour diet recall and dietary questionnaires against 24-hour urinary nitrogen in the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study

Slimani N., Bingham S., Runswick S., Ferrari P., Day N.E., Welch A.A., Key T.J., Miller A.B., Boeing H., Sieri S., Veglia F., Palli D., Panico S., Tumino R., Bueno-de-Mesquita B., Ocke M.C., Clavel-Chapelon F., Trichopoulou A., van Staveren W.A., Riboli E.

Cancer Epidemiol Biomarkers Prev; 2003; 12(8): 784-795
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20