Research Groups

Mechanisms of Carcinogenesis - Epigenetics Group

Key Recent Publications

1. Ichim G, Mola M, Finkbeiner MG, Cros MP, Herceg Z, Hernandez-Vargas H (2014) The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle. Oncogene. 33(2):181-92

2. Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ (2014) Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.. Cell Stem Cell 14(5):632-43

3. Martin M, Ancey PB, Cros MP, Durand G, Le Calvez-Kelm F, Hernandez-Vargas H1, Herceg Z (2014) Dynamic imbalance between cancer cell subpopulations induced by transforming growth factor beta (TGF-β) is associated with a DNA methylome switch. BMC Genomics 15:435

4. Genevois AL, Ichim G, Coissieux MM, Lambert MP, Lavial F, Goldschneider D, Jarrosson-Wuilleme L, Lepinasse F, Gouysse G, Herceg Z, Scoazec JY, Tauszig-Delamasure S, Mehlen P (2013) Dependence receptor TrkC is a putative colon cancer tumor suppressor. Proceedings of the National Academy of Sciences of USA 110(8):3017-22

5. Lee HS, Barraza-Villarreal A, Hernandez-Vargas H, Sly PD, Biessy C, Ramakrishnan U, Romieu I, Herceg Z (2013) Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study. Am J Clin Nutr 98(2):480-7

6. Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z (2010) Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PloS One 5:e9749

7. Paliwal A, Vaissiere T, Krais A, Cuenin C, Cros MP, Zaridze D, Moukeria A, Boffetta P, Hainaut P, Brennan P, Herceg Z (2010) Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. Cancer Research 70:2779-2788

8. Loizou JI, Oser G, Shukla V, Sawan C, Murr R, Wang ZQ, Trumpp A, Herceg Z. (2009) Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool. Journal of Immunology 183:6422-6431

9. Vaissière, V., Hung, R., Zaridze, D., Mukeria, A., Cuenin, C., Fasolo, V., Ferro, G., Hainaut, P., Brennan, P., Tost, J., Boffetta, P., Herceg, Z (2009) Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Research 69:243-52

10. Murr R., Loizou L., Yang Y.-G., Cuenin C., Li H., Wang Z.Q. and Herceg Z (2006) Histone acetylation by Trrap/Tip60 modulates loading of repair proteins and repair of DNA double strand breaks. Nature Cell Biology 8:91-99

11. Li H, Cuenin C, Murr M, Wang ZQ, Herceg Z (2004) HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression. EMBO J 23:4824-4835

12. Herceg Z., Hulla W., Gell D., Cuenin C., Lleonart M., Jackson S. & Wang Z.Q (2001) Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nature Genetics 29:206-211