Research Groups

Mechanisms of Carcinogenesis - Epigenetics Group

Previous Publications - All publications 2016-2012

1. Sahay D., Leblanc R., Grunewald T.G., Ambatipudi S., Ribeiro J., Clezardin P., Peyruchaud O. (2015) The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer Oncotarget.; 6(24):20604-20620. PMID: 26098771

2. Paltiel O., Tikellis G., Linet M., Golding J., Lemeshow S., Phillips G., Lamb K., Stoltenberg C., Haberg S.E., Strom M., Granstrom C., Northstone K., Klebanoff M., Ponsonby A.L., Milne E., Pedersen M., Kogevinas M., Ha E., Dwyer T. (2015) Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C) Paediatr.Perinat.Epidemiol.; 29(4):335-345. PMID: 25989709

3. Vaca-Paniagua F., Oliver J., Nogueira da Costa A., Merle P., McKay J., Herceg Z., Holmila R. (2015) Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing Epigenomics.; 7(3):353-362. PMID: 26077425

4. Kracker S., Di Virgilio M., Schwartzentruber J., Cuenin C., Forveille M., Deau M.C., McBride K.M., Majewski J., Gazumyan A., Seneviratne S., Grimbacher B., Kutukculer N., Herceg Z., Cavazzana M., Jabado N., Nussenzweig M.C., Fischer A., Durandy A. (2015) An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex J Allergy Clin.Immunol.; 135(4):998-1007. PMID: 25312759

5. Wild C.P., Bucher J.R., de Jong B.W., Dillner J., von Gertten C., Groopman J.D., Herceg Z., Holmes E., Holmila R., Olsen J.H., Ringborg U., Scalbert A., Shibata T., Smith M.T., Ulrich C., Vineis P., McLaughlin J. (2015) Translational Cancer Research: Balancing Prevention and Treatment to Combat Cancer Globally Journal of the National Cancer Institute; 107(1):. PMID: 25515230

6. da Costa A.N., Plymoth A., Santos-Silva D., Ortiz-Cuaran S., Camey S., Guilloreau P., Sangrajrang S., Khuhaprema T., Mendy M., Lesi O.A., Chang H.K., Oh J.K., Lee D.H., Shin H.R., Kirk G.D., Merle P., Beretta L., Hainaut P. (2015) Osteopontin and latent-TGF beta binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma International journal of cancer; 136(1):172-181. PMID: 24803312

7. Lambert M.P., Ancey P.B., Esposti D.D., Cros M.P., Sklias A., Scoazec J.Y., Durantel D., Hernandez-Vargas H., Herceg Z. (2015) Aberrant DNA methylation of imprinted loci in hepatocellular carcinoma and after in vitro exposure to common risk factors Clin.Epigenetics.; 7(1):15. PMID: 25755686

8. Kuasne H., Colus I.M., Busso A.F., Hernandez-Vargas H., Barros-Filho M.C., Marchi F.A., Scapulatempo-Neto C., Faria E.F., Lopes A., Guimaraes G.C., Herceg Z., Rogatto S.R. (2015) Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers Clin.Epigenetics.; 7(1):46. PMID: 25908946

9. Silver M.J., Kessler N.J., Hennig B.J., Dominguez-Salas P., Laritsky E., Baker M.S., Coarfa C., Hernandez-Vargas H., Castelino J.M., Routledge M.N., Gong Y.Y., Herceg Z., Lee Y.S., Lee K., Moore S.E., Fulford A.J., Prentice A.M., Waterland R.A. (2015) Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment Genome Biol; 16(1):118. PMID: 26062908

10. Thomas N.E., Kricker A., Waxweiler W.T., Dillon P.M., Busam K.J., From L., Groben P.A., Armstrong B.K., Anton-Culver H., Gruber S.B., Marrett L.D., Gallagher R.P., Zanetti R., Rosso S., Dwyer T., Venn A., Kanetsky P.A., Orlow I., Paine S., Ollila D.W., Reiner A.S., Luo L., Hao H., Frank J.S., Begg C.B., Berwick M. (2014) Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study JAMA Dermatol; 150(12):1306-1314. PMID: 25162299

11. Lee H.S., Barraza-Villarreal A., Biessy C., Duarte-Salles T., Sly P.D., Ramakrishnan U., Rivera J., Herceg Z., Romieu I. (2014) Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants Physiol Genomics; 46(23):851-857. PMID: 25293351

12. Hedley C., Sriraksa R., Showeil R., Van Noorden S., El-Bahrawy M. (2014) The frequency and significance of WT-1 expression in serous endometrial carcinoma Hum Pathol; 45(9):1879-1884. PMID: 25033726

13. Caygill C.P., Gatenby P.A., Herceg Z., Lima S.C., Pinto L.F., Watson A., Wu M.S. (2014) Comparative genomic analysis of esophageal cancers Ann N.Y.Acad Sci; 1325(1):69-76. PMID: 25266016

14. McCloskey K., Sun C., Pezic A., Cochrane J., Morley R., Vuillermin P., Burgner D., Dwyer T., Ponsonby A.L. (2014) The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: a population based twin study J Dev.Orig.Health Dis; 5(4):307-313. PMID: 24965137

15. Wang N., Tikellis G., Sun C., Pezic A., Wang L., Wells J.C., Cochrane J., Ponsonby A.L., Dwyer T. (2014) The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio Placenta; 35(7):437-441. PMID: 24816479

16. Tapias A., Zhou Z.W., Shi Y., Chong Z., Wang P., Groth M., Platzer M., Huttner W., Herceg Z., Yang Y.G., Wang Z.Q. (2014) Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions Cell Stem Cell; 14(5):632-643. PMID: 24792116

17. Leduc C., Chemin G., Puget N., Sawan C., Moutahir M., Herceg Z., Khamlichi A.A. (2014) Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells Cell Cycle; 13(10):1583-1589. PMID: 24675885

18. Berwick M., MacArthur J., Orlow I., Kanetsky P., Begg C.B., Luo L., Reiner A., Sharma A., Armstrong B.K., Kricker A., Cust A.E., Marrett L.D., Gruber S.B., Anton-Culver H., Zanetti R., Rosso S., Gallagher R.P., Dwyer T., Venn A., Busam K., From L., White K., Thomas N.E. (2014) MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors Pigment Cell Melanoma Res; 27(3):485-488. PMID: 24406078

19. Siouda M., Frecha C., Accardi R., Yue J., Cuenin C., Gruffat H., Manet E., Herceg Z., Sylla B.S., Tommasino M. (2014) Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression PLoS Pathog.; 10(5):e1004125. PMID: 24809689

20. Guillot C., Hall J., Herceg Z., Merle P., Chemin I. (2014) Update on hepatocellular carcinoma breakthroughs: poly(ADP-ribose) polymerase inhibitors as a promising therapeutic strategy Clin Res Hepatol.Gastroenterol; 38(2):137-142. PMID: 23953496

21. Ponsonby A.L., Dwyer T. (2014) Statistics: Biomedicine must look beyond P values Nature; 507(7491):169. PMID: 24622193

22. Ichim G., Mola M., Finkbeiner M.G., Cros M.P., Herceg Z., Hernandez-Vargas H. (2014) The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle Oncogene; 33(2):181-192. PMID: 23318449

23. Lee H.S., Herceg Z. (2014) The epigenome and cancer prevention: A complex story of dietary supplementation Cancer Lett.; 342(2):275-284. PMID: 22266189

24. Ecsedi S., Hernandez-Vargas H., Lima S.C., Vizkeleti L., Toth R., Lazar V., Koroknai V., Kiss T., Emri G., Herceg Z., Adany R., Balazs M. (2014) DNA methylation characteristics of primary melanomas with distinct biological behaviour PLoS ONE; 9(5):e96612. PMID: 24832207

25. Herceg Z. (2014) Cancer prevention potential of diet and dietary supplements in epigenome modulation ; 43-70.

26. Ghantous A., Saffery R., Cros M.P., Ponsonby A.L., Hirschfeld S., Kasten C., Dwyer T., Herceg Z., Hernandez-Vargas H. (2014) Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling BMC.Biotechnol.; 60. PMID: 24980254

27. Guillot C., Favaudon V., Herceg Z., Sagne C., Sauvaigo S., Merle P., Hall J., Chemin I. (2014) PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models BMC.Cancer; 603. PMID: 25139788

28. Gibbs D.C., Orlow I., Kanetsky P., Luo L., Kricker A., Armstrong B., Anton-Culver H., Gruber S.B., Marrett L., Gallagher R., Zanetti R., Rosso S., Dwyer T., La Pilla E., Begg C.B., Berwick M., Thomas N.E. (2014) Inherited genetic variants associated with occurrence of multiple primary melanoma J Invest Dermatol; 134(8):S6. Meeting Abstract.

29. Durandy A, Kracker S., Schwartzentruber J., Cuenin C., Herceg Z., Jabado N., Nejentsev S, Fischer A. (2014) Immunoglobulin class-switch recombination deficiencies. Selected Abstracts from the 100th J Project Meeting, Antalya, Turkey, March 12-14, 2014 J Clin Immunol; 34(6):696.

30. Martin M., Ancey P.B., Cros M.P., Durand G., Le Calvez-Kelm F., Hernandez-Vargas H., Herceg Z. (2014) Dynamic imbalance between cancer cell subpopulations induced by transforming growth factor beta (TGF-beta) is associated with a DNA methylome switch BMC.Genomics; 435. PMID: 24898317

31. Dai Y., Cros M.P., Pontoizeau C., Elena-Hermann B., Bonn G.K., Hainaut P. (2014) Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism Carcinogenesis; 35(3):635-650. PMID: 24163401

32. Aury-Landas J., Bougeard G., Castel H., Hernandez-Vargas H., Drouet A., Latouche J.B., Schouft M.T., Ferec C., Leroux D., Lasset C., Coupier I., Caron O., Herceg Z., Frebourg T., Flaman J.M. (2013) Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours Eur.J Hum Genet.; 21(12):1369-1376. PMID: 23612572

33. Lee H.S., Hernandez-Vargas H., Biessy C., Romieu I., Herceg Z., Barraza-Villarreal A., Sly P.D., Ramakrishnan U. (2013) Am.J Clin Nutr.; 98(6):1595-1596. PMID: 24259359

34. Thomas N.E., Busam K.J., From L., Kricker A., Armstrong B.K., Anton-Culver H., Gruber S.B., Gallagher R.P., Zanetti R., Rosso S., Dwyer T., Venn A., Kanetsky P.A., Groben P.A., Hao H., Orlow I., Reiner A.S., Luo L., Paine S., Ollila D.W., Wilcox H., Begg C.B., Berwick M. (2013) Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study Journal of clinical oncology; 31(33):4252-4259. PMID: 24127443

35. Gospodinov A., Herceg Z. (2013) Chromatin structure in double strand break repair DNA Repair; 12(10):800-810. PMID: 23919923

36. Browne A., Sriraksa R., Guney T., Rama N., Van Noorden S., Curry E., Gabra H., Stronach E., El-Bahrawy M. (2013) Differential expression of IL-8 and IL-8 receptors in benign, borderline and malignant ovarian epithelial tumours Cytokine; 64(1):413-421. PMID: 23727325

37. Ghantous A., Sinjab A., Herceg Z., Darwiche N. (2013) Parthenolide: from plant shoots to cancer roots Drug Discov.Today; 18(17):894-905. PMID: 23688583

38. Herceg Z., Lambert M.P., van Veldhoven K., Demetriou C., Vineis P., Smith M.T., Straif K., Wild C.P. (2013) Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation Carcinogenesis; 34(9):1955-1967. PMID: 23749751

39. Wild C.P., Scalbert A., Herceg Z. (2013) Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk Environ.Mol.Mutagen.; 54(7):480-499. PMID: 23681765

40. Lee H.S., Barraza-Villarreal A., Hernandez-Vargas H., Sly P.D., Biessy C., Ramakrishnan U., Romieu I., Herceg Z. (2013) Modulation of DNA methylation states and infant immune system by dietary supplementation with omega-3 PUFA during pregnancy in an intervention study Am.J Clin Nutr.; 98(2):480-487. PMID: 23761484

41. Umer M., Herceg Z. (2013) Deciphering the epigenetic code: an overview of DNA methylation analysis methods Antioxid.Redox.Signal.; 18(15):1972-1986. PMID: 23121567

42. Sawan C., Hernandez-Vargas H., Murr R., Lopez F., Vaissiere T., Ghantous A.Y., Cuenin C., Imbert J., Wang Z.Q., Ren B., Herceg Z. (2013) Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells Stem Cells; 31(5):979-991. PMID: 23362228

43. Khoury M.J., Lam T.K., Ioannidis J.P., Hartge P., Spitz M.R., Buring J.E., Chanock S.J., Croyle R.T., Goddard K.A., Ginsburg G.S., Herceg Z., Hiatt R.A., Hoover R.N., Hunter D.J., Kramer B.S., Lauer M.S., Meyerhardt J.A., Olopade O.I., Palmer J.R., Sellers T.A., Seminara D., Ransohoff D.F., Rebbeck T.R., Tourassi G., Winn D.M., Zauber A., Schully S.D. (2013) Transforming epidemiology for 21st century medicine and public health Cancer epidemiology, biomarkers & prevention; 22(4):508-516. PMID: 23462917

44. Genevois A.L., Ichim G., Coissieux M.M., Lambert M.P., Lavial F., Goldschneider D., Jarrosson-Wuilleme L., Lepinasse F., Gouysse G., Herceg Z., Scoazec J.Y., Tauszig-Delamasure S., Mehlen P. (2013) Dependence receptor TrkC is a putative colon cancer tumor suppressor Proceedings of the National Academy of Sciences of the United States of America; 110(8):3017-3022. PMID: 23341610

45. Gospodinov A., Herceg Z. (2013) Shaping chromatin for repair Mutation research; 752(1):45-60. PMID: 23085398

46. Ecsedi S.I., Hernandez-Vargas H., Lima S.C., Herceg Z., Adany R., Balazs M. (2013) Transposable hypomethylation is associated with metastatic capacity of primary melanomas Int.J Clin Exp.Pathol; 6(12):2943-2948. PMID: 24294382

47. Aushev V.N., Zborovskaya I.B., Laktionov K.K., Girard N., Cros M.P., Herceg Z., Krutovskikh V. (2013) Comparisons of microRNA patterns in plasma before and after tumor removal reveal new biomarkers of lung squamous cell carcinoma PLoS ONE; 8(10):e78649. PMID: 24130905

48. Rakosy Z., Ecsedi S., Toth R., Vizkeleti L., Hernandez-Vargas H., Lazar V., Emri G., Szatmari I., Herceg Z., Adany R., Balazs M. (2013) Integrative genomics identifies gene signature associated with melanoma ulceration PLoS ONE; 8(1):e54958. PMID: 23383013

49. El Hajj H., Ali J., Ghantous A., Hodroj D., Daher A., Zibara K., Journo C., Otrock Z., Zaatari G., Mahieux R., El Sabban M., Bazarbachi A., Abou Merhi R. (2013) Combination of arsenic and interferon-alpha inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas PLoS ONE; 8(11):e79474. PMID: 24250827

50. Demetriou C.A., Chen J., Polidoro S., van Veldhoven K., Cuenin C., Campanella G., Brennan K., Clavel-Chapelon F., Dossus L., Kvaskoff M., Drogan D., Boeing H., Kaaks R., Risch A., Trichopoulos D., Lagiou P., Masala G., Sieri S., Tumino R., Panico S., Quiros J.R., Sanchez Perez M.J., Amiano P., Huerta Castano J.M., Ardanaz E., Onland-Moret C., Peeters P., Khaw K.T., Wareham N., Key T.J., Travis R.C., Romieu I., Gallo V., Gunter M., Herceg Z., Kyriacou K., Riboli E., Flanagan J.M., Vineis P. (2013) Methylome analysis and epigenetic changes associated with menarcheal age PLoS ONE; 8(11):e79391. PMID: 24278132

51. Ouzounova M., Vuong T., Ancey P.B., Ferrand M., Durand G., Le-Calvez Kelm F., Croce C., Matar C., Herceg Z., Hernandez-Vargas H. (2013) MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells BMC.Genomics; 139. PMID: 23445407

52. Nogueira da Costa A., Herceg Z. (2012) Detection of cancer-specific epigenomic changes in biofluids: Powerful tools in biomarker discovery and application Mol Oncol; 6(6):704-715. PMID: 22925902

53. da Costa N.M., Hautefeuille A., Cros M.P., Melendez M.E., Waters T., Swann P., Hainaut P., Pinto L.F. (2012) Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53 Cell Cycle; 11(24):4570-4578. PMID: 23165212

54. Siouda M., Yue J., Shukla R., Guillermier S., Herceg Z., Creveaux M., Accardi R., Tommasino M., Sylla B.S. (2012) Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1 Molecular and cellular biology; 32(23):4877-4890. PMID: 23028047

55. Kesminiene A., Evrard A.S., Ivanov V.K., Malakhova I.V., Kurtinaitise J., Stengrevics A., Tekkel M., Chekin S., Drozdovitch V., Gavrilin Y., Golovanov I., Kryuchkov V.P., Maceika E., Mirkhaidarov A.K., Polyakov S., Tenet V., Tukov A.R., Byrnes G., Cardis E. (2012) Risk of Thyroid Cancer among Chernobyl Liquidators Radiation research; 178(5):425-436. PMID: 22998226

56. Mahabir S., Aagaard K., Anderson L.M., Herceg Z., Hiatt R.A., Hoover R.N., Linet M.S., Medina D., Potischman N., Tretli S., Trichopoulos D., Troisi R. (2012) Challenges and opportunities in research on early-life events/exposures and cancer development later in life Cancer causes & control : CCC; 23(6):983-990. PMID: 22527169

57. Xu X., Gammon M.D., Hernandez-Vargas H., Herceg Z., Wetmur J.G., Teitelbaum S.L., Bradshaw P.T., Neugut A.I., Santella R.M., Chen J. (2012) DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study FASEB journal; 26(6):2657-2666. PMID: 22371529

58. Saulnier A., Vaissiere T., Yue J., Siouda M., Malfroy M., Accardi R., Creveaux M., Sebastian S., Shahzad N., Gheit T., Hussain I., Torrente M., Maffini F.A., Calabrese L., Chiesa F., Cuenin C., Shukla R., Fathallah I., Matos E., Daudt A., Koifman S., Wunsch-Filho V., Menezes A.M., Curado M.P., Zaridze D., Boffetta P., Brennan P., Tommasino M., Herceg Z., Sylla B.S. (2012) Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers International journal of cancer; 130(11):2484-2494. PMID: 21796618

59. Kaur P., Mani S., Cros M.P., Scoazec J.Y., Chemin I., Hainaut P., Herceg Z. (2012) Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma Tumour biology; 33(2):325-336. PMID: 22351518

60. Mani S., Szymanska K., Cuenin C., Zaridze D., Balassiano K., Lima S.C., Matos E., Daudt A., Koifman S., Filho V.W., Menezes A.M., Curado M.P., Ferro G., Vaissiere T., Sylla B.S., Tommasino M., Pinto L.F., Boffetta P., Hainaut P., Brennan P., Herceg Z. (2012) DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract Epigenetics; 7(3):270-277. PMID: 22430803

61. Zoldos V., Horvat T., Novokmet M., Cuenin C., Muzinic A., Pucic M., Huffman J.E., Gornik O., Polasek O., Campbell H., Hayward C., Wright A.F., Rudan I., Owen K., McCarthy M.I., Herceg Z., Lauc G. (2012) Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome Epigenetics; 7(2):164-172. PMID: 22395466

62. Martin M., Herceg Z. (2012) From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Genome Med; 4(1):8. PMID: 22293089