Research Groups

Recent Publications:

1. McKay JD, Truong T, Gaborieau V, Chabrier A, Shu-chun Chuang, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, … Blanche H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P (2011). A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet, 7(3):e1001333. PMID:21556331

2. Le Calvez-Kelm F, Lesueur F, Damiola F, Vallée M, Voegele C, Babikyan D, Durand G, Forey N, McKay-Chopin S, Robinot N, Nguyen-Dumont T, Thomas A, Byrnes GB; Breast Cancer Family Registry, Hopper JL, Southey MC, Andrulis IL, John EM, Tavtigian SV (2011). Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study. Breast Cancer Res, 18, 13(1) R6. PMID:21244692

3. Hernández-Vargas H, Ouzounova M, Calvez-Kelm FL, Lambert MP, McKay-Chopin S, Tavtigian SV, Puisieux A, Matar C, Herceg Z. Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells. Epigenetics. 2011 Apr 1;6(4). [Epub ahead of print] PMID: 21266853

4. Nguyen-Dumont T, Jordheim LP, Michelon J, Forey N, McKay-Chopin S, For Research Into Familial Aspects Of Breast Cancer Kconfab KC, Sinilnikova O, Le Calvez-Kelm F, Southey MC, Tavtigian SV, Lesueur F (2011). Detecting differential allelic expression using high-resolution melting curve analysis: validation on the breast cancer susceptibility gene CHEK2. BMC Med Genomics, 11, 4(1), 39. PMID:21569354

5. Voegele C, Alteyrac L, Caboux E, Smans M, Lesueur F, Le Calvez-Kelm F, Hainaut P (2010). A sample storage management system for biobanks. Bioinformatics, 26(21), 2798-800. PMID:20807837

6. Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z (2010). Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One, 5, e9749. PMID:20305825

7. Tavtigian SV, Oefner PJ, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Babikyan D, Byrnes GB, Chuang S-C, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas S, Vallée M, Voegele C, Webb PM, Whiteman DC, Australian Cancer Study, BCFR, kConFab, Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G (2009). Rare evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am J Hum Genet, 85, 427-46. PMID:19781682

8. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, ……, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008). A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature, 452, 633-7. PM:18385738

9. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, …., Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008). Lung cancer susceptibility locus at 5p15.33. Nature Genet, 40(12), 1404-6. PM:18978790

10. Hashibe M, McKay JD, Curado Oliveira J, Koifman S, Koifman R, Zaridze D, Mukeria A, Wünsch-Filho V, Eluf Neto J, Eduardo Levi J, Matos E, Lagiou P, Lagiou A, Benhamou S, Bouchardy C, Szeszenia-Dabrowska N, …, Lissowska J, Chabrier A, Hung RJ,, Gaborieau V, Boffetta P, Brennan P (2008). Multiple ADH genes are associated with upper aero-digestive cancers in three large independent studies Nature Genet, 40(6), 707-9. PM:18500343

11. Lesueur F, de Lichy, M, Barrois M, Durand G, Bombled J, Avril MF, Chompret A, Boitier F, Lenoir G, French Familial Study Group, Bressac-de Paillerets B (2008). The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma. Br J Cancer, 99, 364-370. PMID:18612309

12. Voegele C, Tavtigian SV, de Silva D, Cuber S, Thomas A and Le Calvez-Kelm F (2007). A laboratory Information Management System (LIMS) for high throughput genetic platform aimed at candidate gene mutation screening. Bioinformatics, 23, 2504-6. PMID:17709339