Research Groups

Section of Genetics - Genetic Cancer Susceptibility Group

Key Recent Publications

1. McKay JD, Truong T, Gaborieau V, Chabrier A, Shu-chun Chuang, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Blanche H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P (2011) A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet 7(3):e1001333

2. Le Calvez-Kelm F, Lesueur F, Damiola F, Vallée M, Voegele C, Babikyan D, Durand G, Forey N, McKay-Chopin S, Robinot N, Nguyen-Dumont T, Thomas A, Byrnes GB; Breast Cancer Family Registry, Hopper JL, Southey MC, Andrulis IL, John EM, Tavtigian SV (2011) Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study. Breast Cancer Res, 18 13(1):R6

3. Hernández-Vargas H, Ouzounova M, Calvez-Kelm FL, Lambert MP, McKay-Chopin S, Tavtigian SV, Puisieux A, Matar C, Herceg Z (2011) Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells. Epigenetics 6(4):428-39

4. Nguyen-Dumont T, Jordheim LP, Michelon J, Forey N, McKay-Chopin S, For Research Into Familial Aspects Of Breast Cancer Kconfab KC, Sinilnikova O, Le Calvez-Kelm F, Southey MC, Tavtigian SV, Lesueur F (2011) Detecting differential allelic expression using high-resolution melting curve analysis: validation on the breast cancer susceptibility gene CHEK2.. BMC Med Genomics 4:39

5. Voegele C, Alteyrac L, Caboux E, Smans M, Lesueur F, Le Calvez-Kelm F, Hainaut P (2010) A sample storage management system for biobanks. Bioinformatics 26(21):2798-800

6. Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z (2010) Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One 5:e9749

7. Tavtigian SV, Oefner PJ, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Babikyan D, Byrnes GB, Chuang S-C, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas S, Vallée M, Voegele C, Webb PM, Whiteman DC, Australian Cancer Study, BCFR, kConFab, Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G (2009) Rare evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am J Hum Genet 85:427-46

8. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008) A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452:633-7

9. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008) Lung cancer susceptibility locus at 5p15.33. Nature Genet 40(12):1404-6

10. Hashibe M, McKay JD, Curado Oliveira J, Koifman S, Koifman R, Zaridze D, Mukeria A, Wünsch-Filho V, Eluf Neto J, Eduardo Levi J, Matos E, Lagiou P, Lagiou A, Benhamou S, Bouchardy C, Szeszenia-Dabrowska N, Lissowska J, Chabrier A, Hung RJ,, Gaborieau V, Boffetta P, Brennan P (2008) Multiple ADH genes are associated with upper aero-digestive cancers in three large independent studies. Nature Genet 40(6):707-9

11. Lesueur F, de Lichy, M, Barrois M, Durand G, Bombled J, Avril MF, Chompret A, Boitier F, Lenoir G, French Familial Study Group, Bressac-de Paillerets B (2008) The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma. Br J Cancer 99:364-370

12. Voegele C, Tavtigian SV, de Silva D, Cuber S, Thomas A and Le Calvez-Kelm F (2007) A laboratory Information Management System (LIMS) for high throughput genetic platform aimed at candidate gene mutation screening. Bioinformatics 23:2504-6