Research Groups

Section of Infections - Infections and Cancer Biology Group

Key Recent Publications

1. Cazzaniga M, Gheit T, Casadio C, Khan N, Macis D, Valenti F, Miller MJ, Sylla BS, Akiba S, Bonanni B, Decensi A, Veronesi U and Tommasino M (2009) Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis. Breast Cancer Res Treat 114:599-605

2. Cardone RA, Busco G, Greco MR, Bellizzi A, Accardi R, Cafarelli A, Monterisi S, Carratù P, Casavola V, Paradiso A, Tommasino M and Reshkin SJ (2008) HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha. PloS One 3(10):e3529

3. Dong W, Arpin C, Accardi R, Gissmann L, Sylla BS, Marvel J and Tommasino M (2008) Loss of p53 or p73 in human papillomavirus type 38 E6 and E7 transgenic mice partially restores the UV-activated cell cycle checkpoints. Oncogene 27:2923-8

4. Gabet AS, Accardi R, Bellopede A, Popp S, Boukamp P, Sylla BS, Londoño-Vallejo JA and Tommasino M (2008) Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin Human Papillomavirus type 38. FASEB J 22:622-32

5. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M and Vlach J (2007) Cell proliferation and survival induced by TLRs is antagonized by type I Interferons. Proc Natl Acad Sci USA 104:8047-52

6. Hasan UA, Bates E, Takeshita F, Biliato A, Accardi R, Bouvard V, Mansour M, Vincent I, Gissmann L, Iftner T, Sideri M, Stubenrauch F and Tommasino M (2007) TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16. J Immunol 178:3186-97

7. Lee S, Huang H, Niu Y, Tommasino M, Lenoir G and Sylla BS (2007) Dok1 expression and mutation in Burkitt's lymphoma cell lines. Cancer Lett 245:44-50

8. Niu Y, Roy F, Saltel F, Andrieu-Soler C, Dong W, Chantegrel AL, Accardi R, Thépot A, Foiselle N, Tommasino M, Jurdic P and Sylla BS (2006) Nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functions. Mol Cell Biol 26:4288-301

9. Accardi R, Dong W, Smet A, Cui R, Hautefeuille A, Gabet AS, Sylla BS, Gissmann L, Hainaut P and Tommasino M (2006) Skin human papillomavirus type 38 alters p53 functions via accumulation of _Np73. EMBO Rep. 7:334-40

10. Dong W, Klotz U, Accardi R, Caldeira S, Tong WM, Wang ZQ, Jansen L, Dürst M, Sylla BS, Gissmann L and Tommasino M (2005) Skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing E6 and E7 of human papillomavirus type 38. J Virol 79:14899-908