Research Groups

Mechanisms of Carcinogenesis - Molecular Mechanisms and Biomarkers Group

Previous Publications - All publications 2015-2011

1. Jelakovic B., Castells X., Tomic K., Ardin M., Karanovic S., Zavadil J. (2015) Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid Int.J Cancer; 136(12):2967-2972. PMID: 25403517

2. Vaca-Paniagua F., Oliver J., Nogueira da Costa A., Merle P., McKay J., Herceg Z., Holmila R. (2015) Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing Epigenomics.; 7(3):353-362. PMID: 26077425

3. Wild C., Brennan P., Plummer M., Bray F., Straif K., Zavadil J. (2015) Cancer risk: role of chance overstated Science; 347(6223):728. PMID: 25656657

4. Krais A.M., Muhlbauer K.R., Kucab J.E., Chinbuah H., Cornelius M.G., Wei Q.X., Hollstein M., Phillips D.H., Arlt V.M., Schmeiser H.H. (2015) Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts Toxicol In Vitro; 29(1):34-43. PMID: 25230394

5. Mariga A., Zavadil J., Ginsberg S.D., Chao M.V. (2015) Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function Dev.Neurobiol.; 75(2):173-192. PMID: 25059794

6. Ose J., Fortner R.T., Schock H., Peeters P.H., Onland-Moret N.C., Bueno-de-Mesquita H.B., Weiderpass E., Gram I.T., Overvad K., Tjonneland A., Dossus L., Fournier A., Baglietto L., Trichopoulou A., Benetou V., Trichopoulos D., Boeing H., Masala G., Krogh V., Matiello A., Tumino R., Popovic M., Obon-Santacana M., Larranaga N., Ardanaz E., Sanchez M., Menendez V., Chirlaque M., Travis R.C., Khaw K., Brandstedt J., Idahl A., Lundin E., Rinaldi S., Kuhn E., Romieu I., Gunter M.J., Merritt M.A., Riboli E., Kaaks R. (2015) Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort British journal of cancer; 112(1):162-166. PMID: 25349976

7. Ose J., Fortner R.T., Rinaldi S., Schock H., Overvad K., Tjonneland A., Hansen L., Dossus L., Fournier A., Baglietto L., Romieu I., Kuhn E., Boeing H., Trichopoulou A., Lagiou P., Trichopoulos D., Palli D., Masala G., Sieri S., Tumino R., Sacerdote C., Mattiello A., Ramon Quiros J., Obon-Santacana M., Larranaga N., Chirlaque M.D., Sanchez M.J., Barricarte A., Peeters P.H., Bueno-de-Mesquita H.B., Onland-Moret N.C., Brandstedt J., Lundin E., Idahl A., Weiderpass E., Gram I.T., Lund E., Kaw K.T., Travis R.C., Merritt M.A., Gunther M.J., Riboli E., Kaaks R. (2015) Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition Int.J.Cancer; 136(2):399-410. PMID: 24890047

8. Tissot C., Toffart A.C., Villar S., Souquet P.J., Merle P., Moro-Sibilot D., Perol M., Zavadil J., Brambilla C., Olivier M., Couraud S. (2015) Assessment of circulating free DNA concentration as a prognostic and predictive biomarker in a large cohort of non-small cell lung cancer treated by platinum-based chemotherapy. Journal of clinical oncology; 33(15):Suppl. Abstract: 110.

9. Vaca-Paniagua F., Alvarez-Gomez R.M., Maldonado-Martinez H.A., Perez-Plasencia C., Fragoso-Ontiveros V., Lasa-Gonsebatt F., Herrera L.A., Cantu D., Bargallo-Rocha E., Mohar A., Durand G., Forey N., Voegele C., Vallee M., Le Calvez-Kelm F., McKay J., Ardin M., Villar S., Zavadil J., Olivier M. (2015) Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues PLoS.One.; 10(5):e0126762. PMID: 25961742

10. Izetti P., Hautefeuille A., Abujamra A.L., de Farias C.B., Giacomazzi J., Alemar B., Lenz G., Roesler R., Schwartsmann G., Osvaldt A.B., Hainaut P., Ashton-Prolla P. (2014) PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines Invest New Drugs; 32(5):783-794. PMID: 24838627

11. SEQC/MAQC-III Consortium (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium Nat Biotechnol.; 32(9):903-914. PMID: 25150838

12. Couraud S., Vaca-Paniagua F., Villar S., Oliver J., Schuster T., Blanche H., Girard N., Tredaniel J., Guilleminault L., Gervais R., Prim N., Vincent M., Margery J., Larive S., Foucher P., Duvert B., Vallee M., Le Calvez-Kelm F., McKay J., Missy P., Morin F., Zalcman G., Olivier M., Souquet P.J. (2014) Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002 Clinical cancer research; 20(17):4613-4624. PMID: 25013125

13. Ma X., Rousseau V., Sun H., Lantuejoul S., Filipits M., Pirker R., Popper H., Mendiboure J., Vataire A.L., Le Chevalier T., Soria J.C., Brambilla E., Dunant A., Hainaut P. (2014) Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer Mol.Oncol; 8(3):555-564. PMID: 24495481

14. Sagne C., Marcel V., Bota M., Martel-Planche G., Nobrega A., Palmero E.I., Perriaud L., Boniol M., Vagner S., Cox D.G., Chan C.S., Mergny J.L., Olivier M., Ashton-Prolla P., Hall J., Hainaut P., Achatz M.I. (2014) Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures Carcinogenesis; 35(4):807-815. PMID: 24336192

15. Cortot A.B., Younes M., Martel-Planche G., Guibert B., Isaac S., Souquet P.J., Commo F., Girard P., Fouret P., Brambilla E., Hainaut P., Soria J.C. (2014) Mutation of TP53 and Alteration of p14(arf) Expression in EGFR- and KRAS-mutated lung adenocarcinomas. Clin Lung Cancer; 15(2):124-130. PMID: 24169260

16. Scelo G., Riazalhosseini Y., Greger L., Letourneau L., Gonzalez-Porta M., Wozniak M.B., Bourgey M., Harnden P., Egevad L., Jackson S.M., Karimzadeh M., Arseneault M., Lepage P., How-Kit A., Daunay A., Renault V., Blanche H., Tubacher E., Sehmoun J., Viksna J., Celms E., Opmanis M., Zarins A., Vasudev N.S., Seywright M., Abedi-Ardekani B., Carreira C., Selby P.J., Cartledge J.J., Byrnes G., Zavadil J., Su J., Holcatova I., Brisuda A., Zaridze D., Moukeria A., Foretova L., Navratilova M., Mates D., Jinga V., Artemov A., Nedoluzhko A., Mazur A., Rastorguev S., Boulygina E., Heath S., Gut M., Bihoreau M.T., Lechner D., Foglio M., Gut I.G., Skryabin K., Prokhortchouk E., Cambon-Thomsen A., Rung J., Bourque G., Brennan P., Tost J., Banks R.E., Brazma A., Lathrop G.M. (2014) Variation in genomic landscape of clear cell renal cell carcinoma across Europe Nat Commun.; 5135. PMID: 25351205

17. Karanovic S., Tomic K., Dittrich D., Borovecki F., Zavadil J., Vukovic-Lela I., Karlovic K., Knezevic M., Jelakovic B. (2014) Endemic (Balkan) nephropathy is aristolochic acid nephropathy Prilozi.; 35(1):43-46. PMID: 24798595

18. Zavadil J. (2014) Multi-'Omics Approaches to Environmental Cancer Risk Factors: A Spotlight on Exposure to Aristolochic Acid and Its Biological Consequences Environ Mol Mutagen; S23 (S15).

19. Mimoso C., Lee D.D., Zavadil J., Tomic-Canic M., Blumenberg M. (2014) Analysis and meta-analysis of transcriptional profiling in human epidermis Methods Mol.Biol.; 61-97. PMID: 24297317

20. Dai Y., Cros M.P., Pontoizeau C., Elena-Hermann B., Bonn G.K., Hainaut P. (2014) Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism Carcinogenesis; 35(3):635-650. PMID: 24163401

21. Olivier M., Weninger A., Ardin M., Huskova H., Castells X., Vallee M.P., McKay J., Nedelko T., Muehlbauer K.R., Marusawa H., Alexander J., Hazelwood L., Byrnes G., Hollstein M., Zavadil J. (2014) Modelling mutational landscapes of human cancers in vitro Sci Rep.; 4482. PMID: 24670820

22. Giacomazzi J., Graudenz M.S., Osorio C.A., Koehler-Santos P., Palmero E.I., Zagonel-Oliveira M., Michelli R.A., Neto C.S., Fernandes G.C., Achatz M.I., Martel-Planche G., Soares F.A., Caleffi M., Goldim J.R., Hainaut P., Camey S.A., Ashton-Prolla P. (2014) Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in Brazil PLoS ONE; 9(6):e99893. PMID: 24936644

23. Ortiz-Cuaran S., Cox D., Villar S., Friesen M.D., Durand G., Chabrier A., Khuhaprema T., Sangrajrang S., Ognjanovic S., Groopman J.D., Hainaut P., Le Calvez-Kelm F. (2013) Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma Genes Chromosomes.Cancer; 52(10):912-919. PMID: 23836507

24. Sighoko D., Kamate B., Traore C., Malle B., Coulibaly B., Karidiatou A., Diallo C., Bah E., McCormack V., Muwonge R., Bourgeois D., Gormally E., Curado M.P., Bayo S., Hainaut P. (2013) Breast cancer in pre-menopausal women in West Africa: analysis of temporal trends and evaluation of risk factors associated with reproductive life Breast; 22(5):828-835. PMID: 23489760

25. Hollstein M., Moriya M., Grollman A.P., Olivier M. (2013) Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid Mutat.Res.; 753(1):41-49. PMID: 23422071

26. Shepherd F.A., Domerg C., Hainaut P., Janne P.A., Pignon J.P., Graziano S., Douillard J.Y., Brambilla E., Le Chevalier T., Seymour L., Bourredjem A., Le Teuff G., Pirker R., Filipits M., Rosell R., Kratzke R., Bandarchi B., Ma X., Capelletti M., Soria J.C., Tsao M.S. (2013) Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy Journal of clinical oncology; 31(17):2173-2181. PMID: 23630215

27. Lu X., Wontakal S.N., Kavi H., Kim B.J., Guzzardo P.M., Emelyanov A.V., Xu N., Hannon G.J., Zavadil J., Fyodorov D.V., Skoultchi A.I. (2013) Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9 Science; 340(6128):78-81. PMID: 23559249

28. Ortiz-Cuaran S., Villar S., Gouas D., Ferro G., Plymoth A., Khuhaprema T., Kalalak A., Sangrajrang S., Friesen M.D., Groopman J.D., Hainaut P. (2013) Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand Cancer letters; 331(1):46-51. PMID: 23200676

29. Dichtel-Danjoy M.L., Ma D., Dourlen P., Chatelain G., Napoletano F., Robin M., Corbet M., Levet C., Hafsi H., Hainaut P., Ryoo H.D., Bourdon J.C., Mollereau B. (2013) Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation Cell Death.Differ.; 20(1):108-116. PMID: 22898807

30. Hainaut P., Olivier M., Wiman K.G. (2013) P53 in the Clinics ; -355p..

31. Hainaut P. (2013) TP53: coordinator of the processes that underlie the hallmarks of cancer ; 1-23.

32. Olivier M. (2013) TP53 somatic mutations: prognostic and predictive value in human cancers ; 127-146.

33. Langerod A., Olivier M., Borresen-Dale A.L. (2013) ; 147-165.

34. Fye H.K., Wright-Drakesmith C., Kramer H.B., Camey S., Nogueira da Costa A., Jeng A., Bah A., Kirk G.D., Sharif M.I., Ladep N.G., Okeke E., Hainaut P., Taylor-Robinson S.D., Kessler B.M., Mendy M.E. (2013) Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations PLoS.One.; 8(7):e68381. PMID: 23935864

35. Hafsi H., Santos-Silva D., Courtois-Cox S., Hainaut P. (2013) Effects of Delta40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53 BMC.Cancer; 134. PMID: 23514281

36. Sagne C., Marcel V., Amadou A., Hainaut P., Olivier M., Hall J. (2013) A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects Cell Death.Dis; e492. PMID: 23412385

37. Gouas D.A., Villar S., Ortiz-Cuaran S., Legros P., Ferro G., Kirk G.D., Lesi O.A., Mendy M., Bah E., Friesen M.D., Groopman J., Chemin I., Hainaut P. (2012) TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia Carcinogenesis; 33(6):1219-1224. PMID: 22759751

38. Scoccianti C., Vesin A., Martel G., Olivier M., Brambilla E., Timsit J.F., Tavecchio L., Brambilla C., Field J.K., Hainaut P. (2012) Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort European respiratory journal; 40(1):177-184. PMID: 22267755

39. Gembarska A., Luciani F., Fedele C., Russell E.A., Dewaele M., Villar S., Zwolinska A., Haupt S., de Lange J., Yip D., Goydos J., Haigh J.J., Haupt Y., Larue L., Jochemsen A., Shi H., Moriceau G., Lo R.S., Ghanem G., Shackleton M., Bernal F., Marine J.C. (2012) MDM4 is a key therapeutic target in cutaneous melanoma Nature Medicine; 18(8):1239-1247. PMID: 22820643

40. de Fraipont F., Levallet G., Creveuil C., Bergot E., Beau-Faller M., Mounawar M., Richard N., Antoine M., Rouquette I., Favrot M.C., Debieuvre D., Braun D., Westeel V., Quoix E., Brambilla E., Hainaut P., Moro-Sibilot D., Morin F., Milleron B., Zalcman G. (2012) An apoptosis methylation prognostic signature for early lung cancer in the IFCT-0002 trial Clinical cancer research; 18(10):2976-2986. PMID: 22434665

41. Shang S., Plymoth A., Ge S., Feng Z., Rosen H.R., Sangrajrang S., Hainaut P., Marrero J.A., Beretta L. (2012) Identification of osteopontin as a novel marker for early hepatocellular carcinoma Hepatology; 55(2):483-490. PMID: 21953299

42. Blandino G., Deppert W., Hainaut P., Levine A., Lozano G., Olivier M., Rotter V., Wiman K., Oren M. (2012) Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop Cell death and differentiation; 19(1):180-183. PMID: 22095277

43. Hainaut P., Plymoth A. (2012) Cancer as a metabolic disease Current opinion in oncology; 24(1):56-57. PMID: 22143370

44. Abedi-Ardekani B., Dar N.A., Mir M.M., Zargar S.A., Lone M.M., Martel-Planche G., Villar S., Mounawar M., Saidi F., Malekzadeh R., Hainaut P. (2012) Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia BMC.Cancer; 602. PMID: 23244191

45. Ognjanovic S., Martel G., Manivel C., Olivier M., Langer E., Hainaut P. (2012) Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma Sarcoma; 492086. PMID: 22550420

46. Villar S., Ortiz-Cuaran S., Abedi-Ardekani B., Gouas D., Nogueira da Costa A., Plymoth A., Khuhaprema T., Kalalak A., Sangrajrang S., Friesen M.D., Groopman J.D., Hainaut P. (2012) Aflatoxin-Induced TP53 R249S Mutation in HepatoCellular Carcinoma in Thailand: Association with Tumors Developing in the Absence of Liver Cirrhosis PLoS ONE; 7(6):e37707. PMID: 22675488

47. Fernandez-Cuesta L., Oakman C., Falagan-Lotsch P., Smoth K.S., Quinaux E., Buyse M., Dolci M.S., Azambuja E.D., Hainaut P., Dell'orto P., Larsimont D., Francis P.A., Crown J., Piccart-Gebhart M., Viale G., Leo A.D., Olivier M. (2012) Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial Breast cancer research; 14(3):R70. PMID: 22551440

48. Balassiano K., Lima S., Jenab M., Overvad K., Tjonneland A., Boutron-Ruault M.C., Clavel-Chapelon F., Canzian F., Kaaks R., Boeing H., Meidtner K., Trichopoulou A., Laglou P., Vineis P., Panico S., Palli D., Grioni S., Tumino R., Lund E., Bueno-de-Mesquita H.B., Numans M.E., Peeters P.H., Ramon Quiros J., Sanchez M.A., Navarro C., Ardanaz E., Dorronsoro M., Hallmans G., Stenling R., Ehrnstrom R., Regner S., Allen N.E., Travis R.C., Khaw K.T., Offerhaus G.J., Sala N., Riboli E., Hainaut P., Scoazec J.Y., Sylla B.S., Gonzalez C.A., Herceg Z. (2011) Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) Cancer letters; 311(1):85-95. PMID: 21831520

49. da Silva E.M., Achatz M.I., Martel-Planche G., Montagnini A.L., Olivier M., Prolla P.A., Hainaut P., Soares F.A. (2011) TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report BMC cancer; 11(1):449. PMID: 22004116

50. Krais A.M., Hautefeuille A.H., Cros M.P., Krutovskikh V., Tournier J.M., Birembaut P., Thepot A., Paliwal A., Herceg Z., Boffetta P., Brennan P., Hainaut P.L. (2011) CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression Carcinogenesis; 32(9):1388-1395. PMID: 21586512

51. Hafsi H., Hainaut P. (2011) Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence Antioxidants & redox signaling; 15(6):1655-1667. PMID: 21194382

52. Moore H.M., Kelly A.B., Jewell S.D., McShane L.M., Clark D.P., Greenspan R., Hayes D.F., Hainaut P., Kim P., Mansfield E., Potapova O., Riegman P., Rubinstein Y., Seijo E., Somiari S., Watson P., Weier H.U., Zhu C., Vaught J. (2011) Biospecimen Reporting for Improved Study Quality (BRISQ) J Proteome Res; 10(8):3429-3438. PMID: 21574648

53. Beau-Faller M., Degeorges A., Rolland E., Mounawar M., Antoine M., Poulot V., Mauguen A., Barbu V., Coulet F., Pretet J.L., Bieche I., Blons H., Boyer J.C., Buisine M.P., de Fraipont F., Lizard S., Olschwang S., Saulnier P., Prunier-Mirebeau D., Richard N., Danel C., Brambilla E., Chouaid C., Zalcman G., Hainaut P., Michiels S., Cadranel J. (2011) Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status for the Administration of EGFR-TKIs in Non-Small Cell Lung Carcinoma [ERMETIC] Project-Part 1) J Thorac Oncol; 6(6):1006-1015. PMID: 21532509

54. Nogueira da Costa A., Mijal R.S., Keen J.N., Findlay J.B., Wild C.P. (2011) Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol Proteomics; 11(10):1903-1914. PMID: 21462343

55. Lambert M.P., Paliwal A., Vaissiere T., Chemin I., Zoulim F., Tommasino M., Hainaut P., Sylla B., Scoazec J.Y., Tost J., Herceg Z. (2011) Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake J Hepatol; 54(4):705-715. PMID: 21146512

56. Brennan P., Hainaut P., Boffetta P. (2011) Genetics of lung-cancer susceptibility Lancet oncology; 12(4):399-408. PMID: 20951091

57. Fernandez-Cuesta L., Anaganti S., Hainaut P., Olivier M. (2011) p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines International journal of cancer; 128(8):1813-1821. PMID: 20549698

58. Moore H.M., Kelly A.B., Jewell S.D., McShane L.M., Clark D.P., Greenspan R., Hayes D.F., Hainaut P., Kim P., Mansfield E.A., Potapova O., Riegman P., Rubinstein Y., Seijo E., Somiari S., Watson P., Weier H.U., Zhu C., Vaught J. (2011) Biospecimen reporting for improved study quality (BRISQ) Cancer Cytopathol; 119(2):92-102. PMID: 21433001

59. Moore H.M., Kelly A., Jewell S.D., McShane L.M., Clark D.P., Greenspan R., Hainaut P., Hayes D.F., Kim P., Mansfield E., Potapova O., Riegman P., Rubinstein Y., Seijo E., Somiari S., Watson P., Weier H.U., Zhu C., Vaught J. (2011) Biospecimen Reporting for Improved Study Quality Biopreserv Biobank; 9(1):57-70. PMID: 21826252

60. Hafsi H., Hainaut P. (2011) Pharmacological rescue of p53 in cancer cells: The soloist meets the PRIMA donna Cell Cycle; 10(6):875-876. PMID: 21358263

61. Marcel V., Tran P.L., Sagne C., Martel-Planche G., Vaslin L., Teulade-Fichou M.P., Hall J., Mergny J.L., Hainaut P., Van Dyck E. (2011) G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms Carcinogenesis; 32(3):271-278. PMID: 21112961

62. Marcel V., Olivier M., Mollereau B., Hainaut P., Bourdon J.C. (2011) First International p53 Isoforms Meeting: 'p53 isoforms through evolution: from identification to biological function' Cell death and differentiation; 18(3):563-564. PMID: 21151028

63. Umoh N.J., Lesi O.A., Mendy M., Bah E., Akano A., Whittle H., Hainaut P., Kirk G.D. (2011) Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia Liver International; 31(2):215-221. PMID: 21143369

64. Franceschi S., Lise M., Trepo C., Berthillon P., Chuang S.C., Nieters A., Travis R.C., Vermeulen R., Overvad K., Tjonneland A., Olsen A., Bergmann M.M., Boeing H., Kaaks R., Becker N., Trichopoulou A., Lagiou P., Bamia C., Palli D., Sieri S., Panico S., Tumino R., Sacerdote C., Bueno-de-Mesquita B., Peeters P.H., Rodriguez L., Barroso L.L., Dorronsoro M., Sanchez M.J., Navarro C., Barricarte A., Regner S., Borgquist S., Melin B., Hallmans G., Khaw K.T., Wareham N., Rinaldi S., Hainaut P., Riboli E., Vineis P. (2011) Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cancer epidemiology, biomarkers & prevention; 20(1):208-214. PMID: 21098651

65. Fernandez-Cuesta L., Anaganti S., Hainaut P., Olivier M. (2011) Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines Breast cancer research and treatment; 125(1):35-42. PMID: 20221692

66. Goldstein I., Marcel V., Olivier M., Oren M., Rotter V., Hainaut P. (2011) Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies Cancer Gene Therapy; 18(1):2-11. PMID: 20966976

67. Anaganti S., Fernandez-Cuesta L., Langerod A., Hainaut P., Olivier M. (2011) p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines Cancer letters; 300(2):215-224. PMID: 21071137

68. Olivier M., Taniere P. (2011) Somatic mutations in cancer prognosis and prediction: lessons from TP53 and EGFR genes Current opinion in oncology; 23(1):88-92. PMID: 21045690

69. Pfeifer G.P., Hainaut P. (2011) Next-generation sequencing: emerging lessons on the origins of human cancer Current opinion in oncology; 23(1):62-68. PMID: 21119514

70. Plymoth A., Hainaut P. (2011) Proteomics beyond proteomics: toward clinical applications Current opinion in oncology; 23(1):77-82. PMID: 21107258

71. Hainaut P., Plymoth A. (2011) Biomarkers in cancer research and treatment: promises and challenges Current opinion in oncology; 23(1):61. PMID: 21321519

72. Galy O., Chemin I., Le Roux E., Villar S., Le Calvez-Kelm F., Lereau M., Gouas D., Vieco B., Suarez I., Navas M.C., Chevallier M., Norder H., Srivatanakul P., Karalak A., Sangrajrang S., Trepo C., Hainaut P. (2011) Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand Hepat Res Treat; doi:10.1155/2011/697. PMID: 21760996

73. Thepot A., Desanlis A., Venet E., Thivillier L., Justin V., Morel A.P., Defraipont F., Till M., Krutovskikh V., Tommasino M., Damour O., Hainaut P. (2011) Assessment of transformed properties in vitro and of tumorigenicity in vivo in primary keratinocytes cultured for epidermal sheet transplantation J Skin Cancer; 936546. PMID: 21188234

74. Hewitt R., Hainaut P. (2011) Biobanking in a fast moving world: an international perspective J Natl Cancer Inst Monogr; 2011(42):50-51. PMID: 21672898

75. Abedi-Ardekani B., Gouas D., Villar S., Sotoudeh M., Hainaut P. (2011) TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations Hepat Res Treat; 475965. PMID: 21869931

76. Navas M.C., Suarez I., Carreno A., Uribe D., Rios W.A., Cortes-Mancera F., Martel G., Vieco B., Lozano D., Jimenez C., Gouas D., Osorio G., Hoyos S., Restrepo J.C., Correa G., Jaramillo S., Lopez R., Bravo L.E., Arbelaez M.P., Scoazec J.Y., Abedi-Ardekani B., Santella R.M., Chemin I., Hainaut P. (2011) Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia Hepat Res Treat; 582945. PMID: 22114738

77. Hainaut P., Vozar B., Rinaldi S., Riboli E., Caboux E. (2011) The European Prospective Investigation into Cancer and Nutrition biobank Methods in Molecular Biology; 179-191. PMID: 20949388

78. Abedi-Ardekani B., Kamangar F., Sotoudeh M., Villar S., Islami F., Aghcheli K., Nasrollahzadeh D., Taghavi N., Dawsey S.M., Abnet C.C., Hewitt S.M., Fahimi S., Saidi F., Brennan P., Boffetta P., Malekzadeh R., Hainaut P. (2011) Extremely high tp53 mutation load in esophageal squamous cell carcinoma in golestan province, iran PLoS ONE; 6(12):e29488. PMID: 22216294

79. Sighoko D., Curado M.P., Bourgeois D., Mendy M., Hainaut P., Bah E. (2011) Increase in female liver cancer in the gambia, west Africa: evidence from 19 years of population-based cancer registration (1988-2006) PLoS ONE; 6(4):e18415. PMID: 21490972