Research Groups

Mechanisms of Carcinogenesis - Molecular Mechanisms and Biomarkers Group

Previous Publications - All publications 2017-2013

1. Hollstein M., Alexandrov L. B., Wild C. P., Ardin M., Zavadil J. (2017) Base changes in tumour DNA have the power to reveal the causes and evolution of cancer Oncogene; 36(2):158-167. PMID: 27270430

2. Vargova J., Vargova K., Dusilkova N., Kulvait V., Pospisil V., Zavadil J., Trneny M., Klener P., Stopka T. (2016) Differential expression, localization and activity of MARCKS between mantle cell lymphoma and chronic lymphocytic leukemia Blood Cancer J; 6(9):e475. PMID: 27662204

3. Bouaoun L., Sonkin D., Ardin M., Hollstein M., Byrnes G., Zavadil J., Olivier M. (2016) TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data Hum Mutat; 37(9):865-76. PMID: 27328919

4. Fernandez-Cuesta L., Perdomo S., Avogbe P. H., Leblay N., Delhomme T. M., Gaborieau V., Abedi-Ardekani B., Chanudet E., Olivier M., Zaridze D., Mukeria A., Vilensky M., Holcatova I., Polesel J., Simonato L., Canova C., Lagiou P., Brambilla C., Brambilla E., Byrnes G., Scelo G., Le Calvez-Kelm F., Foll M., McKay J. D., Brennan P. (2016) Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer EBioMedicine; 117-23. PMID: 27377626

5. Ma X., Le Teuff G., Lacas B., Tsao M. S., Graziano S., Pignon J. P., Douillard J. Y., Le Chevalier T., Seymour L., Filipits M., Pirker R., Janne P. A., Shepherd F. A., Brambilla E., Soria J. C., Hainaut P. (2016) Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis J Thorac Oncol; 11(6):850-61. PMID: 26899019

6. He S., Limi S., McGreal R. S., Xie Q., Brennan L. A., Kantorow W. L., Kokavec J., Majumdar R., Hou H., Edelmann W., Liu W., Ashery-Padan R., Zavadil J., Kantorow M., Skoultchi A. I., Stopka T., Cvekl A. (2016) Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation Development; 143(11):1937-1947. PMID: 27246713

7. Tissot C., Villar S., Olivier M., Couraud S. (2016) [Free circulating DNA as a tool for lung cancer patients management] Rev Pneumol Clin; 72(1):61-71. PMID: 26190335

8. Vojtechova Z., Sabol I., Salakova M., Smahelova J., Zavadil J., Turek L., Grega M., Klozar J., Prochazka B., Tachezy R. (2016) Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones BMC cancer; 382. PMID: 27377959

9. Ardin M., Cahais V., Castells X., Bouaoun L., Byrnes G., Herceg Z., Zavadil J., Olivier M. (2016) MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes BMC Bioinformatics; 170. PMID: 27091472

10. Tissot C., Toffart A. C., Villar S., Souquet P. J., Merle P., Moro-Sibilot D., Perol M., Zavadil J., Brambilla C., Olivier M., Couraud S. (2015) Circulating free DNA concentration is an independent prognostic biomarker in lung cancer Eur Respir J; 46(6):1773-80. PMID: 26493785

11. Castells X., Karanovic S., Ardin M., Tomic K., Xylinas E., Durand G., Villar S., Forey N., Le Calvez-Kelm F., Voegele C., Karlovic K., Misic M., Dittrich D., Dolgalev I., McKay J., Shariat S. F., Sidorenko V. S., Fernandes A., Heguy A., Dickman K. G., Olivier M., Grollman A. P., Jelakovic B., Zavadil J. (2015) Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid Cancer Epidemiol Biomarkers Prev; 24(12):1873-81. PMID: 26383547

12. Wild C., Brennan P., Plummer M., Bray F., Straif K., Zavadil J. (2015) Cancer risk: role of chance overstated Science; 347(6223):728. PMID: 25656657

13. Vaca-Paniagua F., Oliver J., Nogueira da Costa A., Merle P., McKay J., Herceg Z., Holmila R. (2015) Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing Epigenomics; 7(3):353-362. PMID: 26077425

14. Vaca-Paniagua F., Alvarez-Gomez R.M., Maldonado-Martinez H.A., Perez-Plasencia C., Fragoso-Ontiveros V., Lasa-Gonsebatt F., Herrera L.A., Cantu D., Bargallo-Rocha E., Mohar A., Durand G., Forey N., Voegele C., Vallee M., Le Calvez-Kelm F., McKay J., Ardin M., Villar S., Zavadil J., Olivier M. (2015) Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues PLoS. One; 10(5):e0126762. PMID: 25961742

15. Traore F., Gormally E., Villar S., Friesen M. D., Groopman J. D., Vernet G., Diallo S., Hainaut P., Maiga M. Y. (2015) Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali BMC Infect Dis; 180. PMID: 25886382

16. Ose J., Fortner R.T., Schock H., Peeters P.H., Onland-Moret N.C., Bueno-de-Mesquita H.B., Weiderpass E., Gram I.T., Overvad K., Tjonneland A., Dossus L., Fournier A., Baglietto L., Trichopoulou A., Benetou V., Trichopoulos D., Boeing H., Masala G., Krogh V., Matiello A., Tumino R., Popovic M., Obon-Santacana M., Larranaga N., Ardanaz E., Sanchez M., Menendez V., Chirlaque M., Travis R.C., Khaw K., Brandstedt J., Idahl A., Lundin E., Rinaldi S., Kuhn E., Romieu I., Gunter M.J., Merritt M.A., Riboli E., Kaaks R. (2015) Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort Br J Cancer; 112(1):162-166. PMID: 25349976

17. Ose J., Fortner R.T., Rinaldi S., Schock H., Overvad K., Tjonneland A., Hansen L., Dossus L., Fournier A., Baglietto L., Romieu I., Kuhn E., Boeing H., Trichopoulou A., Lagiou P., Trichopoulos D., Palli D., Masala G., Sieri S., Tumino R., Sacerdote C., Mattiello A., Ramon Quiros J., Obon-Santacana M., Larranaga N., Chirlaque M.D., Sanchez M.J., Barricarte A., Peeters P.H., Bueno-de-Mesquita H.B., Onland-Moret N.C., Brandstedt J., Lundin E., Idahl A., Weiderpass E., Gram I.T., Lund E., Kaw K.T., Travis R.C., Merritt M.A., Gunther M.J., Riboli E., Kaaks R. (2015) Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition Int. J. Cancer; 136(2):399-410. PMID: 24890047

18. Mariga A., Zavadil J., Ginsberg S.D., Chao M.V. (2015) Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function Dev. Neurobiol; 75(2):173-192. PMID: 25059794

19. Krais A.M., Muhlbauer K.R., Kucab J.E., Chinbuah H., Cornelius M.G., Wei Q.X., Hollstein M., Phillips D.H., Arlt V.M., Schmeiser H.H. (2015) Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts Toxicol In Vitro; 29(1):34-43. PMID: 25230394

20. Jelakovic B., Castells X., Tomic K., Ardin M., Karanovic S., Zavadil J. (2015) Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid Int. J Cancer; 136(12):2967-2972. PMID: 25403517

21. Scelo G., Riazalhosseini Y., Greger L., Letourneau L., Gonzalez-Porta M., Wozniak M.B., Bourgey M., Harnden P., Egevad L., Jackson S.M., Karimzadeh M., Arseneault M., Lepage P., How-Kit A., Daunay A., Renault V., Blanche H., Tubacher E., Sehmoun J., Viksna J., Celms E., Opmanis M., Zarins A., Vasudev N.S., Seywright M., Abedi-Ardekani B., Carreira C., Selby P.J., Cartledge J.J., Byrnes G., Zavadil J., Su J., Holcatova I., Brisuda A., Zaridze D., Moukeria A., Foretova L., Navratilova M., Mates D., Jinga V., Artemov A., Nedoluzhko A., Mazur A., Rastorguev S., Boulygina E., Heath S., Gut M., Bihoreau M.T., Lechner D., Foglio M., Gut I.G., Skryabin K., Prokhortchouk E., Cambon-Thomsen A., Rung J., Bourque G., Brennan P., Tost J., Banks R.E., Brazma A., Lathrop G.M. (2014) Variation in genomic landscape of clear cell renal cell carcinoma across Europe Nat Commun; 5135. PMID: 25351205

22. Sagne C., Marcel V., Bota M., Martel-Planche G., Nobrega A., Palmero E.I., Perriaud L., Boniol M., Vagner S., Cox D.G., Chan C.S., Mergny J.L., Olivier M., Ashton-Prolla P., Hall J., Hainaut P., Achatz M.I. (2014) Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures Carcinogenesis; 35(4):807-815. PMID: 24336192

23. Olivier M., Weninger A., Ardin M., Huskova H., Castells X., Vallee M.P., McKay J., Nedelko T., Muehlbauer K.R., Marusawa H., Alexander J., Hazelwood L., Byrnes G., Hollstein M., Zavadil J. (2014) Modelling mutational landscapes of human cancers in vitro Sci Rep; 4482. PMID: 24670820

24. Mimoso C., Lee D.D., Zavadil J., Tomic-Canic M., Blumenberg M. (2014) Analysis and meta-analysis of transcriptional profiling in human epidermis Methods Mol. Biol; 61-97. PMID: 24297317

25. Ma X., Rousseau V., Sun H., Lantuejoul S., Filipits M., Pirker R., Popper H., Mendiboure J., Vataire A.L., Le Chevalier T., Soria J.C., Brambilla E., Dunant A., Hainaut P. (2014) Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer Mol. Oncol; 8(3):555-564. PMID: 24495481

26. Karanovic S., Tomic K., Dittrich D., Borovecki F., Zavadil J., Vukovic-Lela I., Karlovic K., Knezevic M., Jelakovic B. (2014) Endemic (Balkan) nephropathy is aristolochic acid nephropathy Prilozi; 35(1):43-46. PMID: 24798595

27. Izetti P., Hautefeuille A., Abujamra A.L., de Farias C.B., Giacomazzi J., Alemar B., Lenz G., Roesler R., Schwartsmann G., Osvaldt A.B., Hainaut P., Ashton-Prolla P. (2014) PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines Invest New Drugs; 32(5):783-794. PMID: 24838627 WOS:0003424

28. Giacomazzi J., Graudenz M.S., Osorio C.A., Koehler-Santos P., Palmero E.I., Zagonel-Oliveira M., Michelli R.A., Neto C.S., Fernandes G.C., Achatz M.I., Martel-Planche G., Soares F.A., Caleffi M., Goldim J.R., Hainaut P., Camey S.A., Ashton-Prolla P. (2014) Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in Brazil PLoS ONE; 9(6):e99893. PMID: 24936644

29. Dai Y., Cros M.P., Pontoizeau C., Elena-Hermann B., Bonn G.K., Hainaut P. (2014) Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism Carcinogenesis; 35(3):635-650. PMID: 24163401

30. Couraud S., Vaca-Paniagua F., Villar S., Oliver J., Schuster T., Blanche H., Girard N., Tredaniel J., Guilleminault L., Gervais R., Prim N., Vincent M., Margery J., Larive S., Foucher P., Duvert B., Vallee M., Le Calvez-Kelm F., McKay J., Missy P., Morin F., Zalcman G., Olivier M., Souquet P.J. (2014) Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002 Clin Cancer Res; 20(17):4613-4624. PMID: 25013125

31. Cortot A.B., Younes M., Martel-Planche G., Guibert B., Isaac S., Souquet P.J., Commo F., Girard P., Fouret P., Brambilla E., Hainaut P., Soria J.C. (2014) Mutation of TP53 and Alteration of p14(arf) Expression in EGFR- and KRAS-mutated lung adenocarcinomas. Clin Lung Cancer; 15(2):124-130. PMID: 24169260

32. SEQC/MAQC-III Consortium (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium Nat Biotechnol; 32(9):903-914. PMID: 25150838

33. Sighoko D., Kamate B., Traore C., Malle B., Coulibaly B., Karidiatou A., Diallo C., Bah E., McCormack V., Muwonge R., Bourgeois D., Gormally E., Curado M.P., Bayo S., Hainaut P. (2013) Breast cancer in pre-menopausal women in West Africa: analysis of temporal trends and evaluation of risk factors associated with reproductive life Breast; 22(5):828-835. PMID: 23489760

34. Shepherd F.A., Domerg C., Hainaut P., Janne P.A., Pignon J.P., Graziano S., Douillard J.Y., Brambilla E., Le Chevalier T., Seymour L., Bourredjem A., Le Teuff G., Pirker R., Filipits M., Rosell R., Kratzke R., Bandarchi B., Ma X., Capelletti M., Soria J.C., Tsao M.S. (2013) Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy J Clin Oncol; 31(17):2173-2181. PMID: 23630215

35. Sagne C., Marcel V., Amadou A., Hainaut P., Olivier M., Hall J. (2013) A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects Cell Death. Dis; e492. PMID: 23412385

36. Ortiz-Cuaran S., Villar S., Gouas D., Ferro G., Plymoth A., Khuhaprema T., Kalalak A., Sangrajrang S., Friesen M.D., Groopman J.D., Hainaut P. (2013) Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand Cancer Lett; 331(1):46-51. PMID: 23200676

37. Ortiz-Cuaran S., Cox D., Villar S., Friesen M.D., Durand G., Chabrier A., Khuhaprema T., Sangrajrang S., Ognjanovic S., Groopman J.D., Hainaut P., Le Calvez-Kelm F. (2013) Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma Genes Chromosomes. Cancer; 52(10):912-919. PMID: 23836507

38. Olivier M. (2013) TP53 somatic mutations: prognostic and predictive value in human cancers ; 127-146.

39. Lu X., Wontakal S.N., Kavi H., Kim B.J., Guzzardo P.M., Emelyanov A.V., Xu N., Hannon G.J., Zavadil J., Fyodorov D.V., Skoultchi A.I. (2013) Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9 Science; 340(6128):78-81. PMID: 23559249

40. Langerod A., Olivier M., Borresen-Dale A.L. (2013) Assessing TP53 status in human tumors: lessons from breast cancer ; 147-165.

41. Hollstein M., Moriya M., Grollman A.P., Olivier M. (2013) Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid Mutat. Res; 753(1):41-49. PMID: 23422071

42. Hainaut P. (2013) TP53: coordinator of the processes that underlie the hallmarks of cancer ; 1-23.

43. Hafsi H., Santos-Silva D., Courtois-Cox S., Hainaut P. (2013) Effects of Delta40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53 BMC. Cancer; 134. PMID: 23514281

44. Giacomazzi J., Selistre S.G., Rossi C., Alemar B., Santos-Silva P., Pereira F.S., Netto C.B., Cossio S.L., Roth D.E., Brunetto A.L., Zagonel-Oliveira M., Martel-Planche G., Goldim J.R., Hainaut P., Camey S.A., Ashton-Prolla P. (2013) Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil Cancer; 119(24):4341-4349. PMID: 24122735

45. Fye H.K., Wright-Drakesmith C., Kramer H.B., Camey S., Nogueira da Costa A., Jeng A., Bah A., Kirk G.D., Sharif M.I., Ladep N.G., Okeke E., Hainaut P., Taylor-Robinson S.D., Kessler B.M., Mendy M.E. (2013) Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations PLoS. One; 8(7):e68381. PMID: 23935864 https://www

46. Dichtel-Danjoy M.L., Ma D., Dourlen P., Chatelain G., Napoletano F., Robin M., Corbet M., Levet C., Hafsi H., Hainaut P., Ryoo H.D., Bourdon J.C., Mollereau B. (2013) Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation Cell Death. Differ; 20(1):108-116. PMID: 22898807