Research Groups

Section of Molecular Pathology

Key Recent Publications

1. Nonoguchi N, Ohta T, Oh JE, Kim YH, Kleihues P, Ohgaki H. (2013) TERT promoter mutations in primary and secondary glioblastomas. Acta Neuropathol. 126:931-937

2. Nagaishi, M., Paulus, W., Brokinkel, B., Vital, A., Tanaka, Y., Nakazato, Y., Giangaspero, F., & Ohgaki, H (2012) Transcriptional Factors for Epithelial-Mesenchymal Transition Are Associated with Mesenchymal Differentiation in Gliosarcoma. Brain Pathol 22:670-676

3. Nagaishi, M., Kim, Y. H., Mittelbronn, M., Giangaspero, A., Paulus, W., Brokinkel, B., Vital, A., Tanaka, Y., Nakazato, Y., Legras-Lachuer, C., Lachuer, J., and Ohgaki, H (2012) Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. Am J Pathol 180:1816-1823

4. Lv, S.Q., Kim, Y.H., Giulio, F., Shalaby, T., Nobusawa, S., Yang, H., Zhou, Z., Grotzer, M., & Ohgaki, H (2012) Genetic Alterations in MicroRNAs in Medulloblastomas. Brain Pathol 22:230-239

5. Kim YH, Nobusawa S, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nakazato Y, Tanaka Y, Vital A, Mariani L, Stawski R, Watanabe T, De Girolami U, Kleihues P, Ohgaki H (2010) Molecular classification of low-grade diffuse gliomas. Am J Pathol 177:2708-2714

6. Nobusawa S, Lachuer J, Wierinck A, Kim YH, Huang J, Legras C, Kleihues P, Ohgaki H (2010) Regional patterns of genomic imbalance in glioblastoma. Brain Pathol. 20:936-944

7. Nobusawa S, Watanabe T, Kleihues P, Ohgaki H (2009) IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin. Cancer Res 15:6002-6009

8. Watanabe T, Vital A, Nobusawa S, Kleihues P, Ohgaki H (2009) IDH1 C394T mutations in astrocytomas associated with Li-Fraumeni syndrome. Acta Neuropathol. 117:653-656

9. Huang J, Pang J, Watanabe T, Ng H-K, Ohgaki H (2009) Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed paraffin-embedded histological sections.. J. Mol. Diagn. 11:109-116

10. Watanabe T, Nobusawa S, Kleihues P, Ohgaki H (2009) IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am. J. Pathol. 174:1149-1153

11. Ohgaki H, Kita D, Favereaux A, Huang H, Homma T, Dessen P, Weiss WA, Kleihues P, Heppner FL (2006) Brain tumors in S100beta-v-erbB transgenic rats. J. Neuropathol. Exp. Neurol. 65:1111-1117

12. Ohgaki, H, Dessen, P, Jourde, B, Horstmann S, Nishikawa T, Di Patre P-L, Burkhard C, Schler D, Probst-Hensch NM, Maiorka PC, Baeza N, Pisani P, Yonekawa Y, Yasargil MG, Ltolf UM, Kleihues P (2004) Genetic pathways to glioblastoma: A population-based study. Cancer Res. 64:6892-6899