Research Groups

Section of Molecular Pathology

Key Recent Publications

1. Kim, Y.H., Ohta, T., Oh, J.E., Le Calvez-Kelm, F., McKay, J., Voegele, C., Durand, G., Mittelbronn, M., Kleihues, P., Paulus, W., & Ohgaki, H. (2014) TP53, MSH4, and LATS1 Germline Mutations in a Family with Clustering of Nervous System Tumors. Am J Pathol 184:2374-2381

2. Ohta, T., Kim, Y.H., Oh, J.E., Satomi, K., Nonoguchi, N., Keyvani, K., Pierscianek, D., Sure, U., Mittelbronn, M., Paulus, W., Vital, A., Yokoo, H., McDonald, K., Kleihues, P., Nazaret, N., Barbet, F., Lachuer, J., & Ohgaki, H. (2014) Alterations of the RRAS and ERCC1 Genes at 19q13 in Gemistocytic Astrocytomas. J Neuropathol Exp. Neurol 73:908-915

3. Ohgaki, H. and Kleihues, P. (2013) The Definition of Primary and Secondary Glioblastoma. . Clin. Cancer Res 19:764-772 (This article is the most-cited review article in Clinical Cancer Research in 2013)

4. Nonoguchi N, Ohta T, Oh JE, Kim YH, Kleihues P, Ohgaki H. (2013) TERT promoter mutations in primary and secondary glioblastomas. Acta Neuropathol. 126:931-937

5. Nagaishi, M., Paulus, W., Brokinkel, B., Vital, A., Tanaka, Y., Nakazato, Y., Giangaspero, F., & Ohgaki, H (2012) Transcriptional Factors for Epithelial-Mesenchymal Transition Are Associated with Mesenchymal Differentiation in Gliosarcoma. Brain Pathol 22:670-676

6. Nagaishi, M., Kim, Y. H., Mittelbronn, M., Giangaspero, A., Paulus, W., Brokinkel, B., Vital, A., Tanaka, Y., Nakazato, Y., Legras-Lachuer, C., Lachuer, J., and Ohgaki, H (2012) Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. Am J Pathol 180:1816-1823

7. Kim YH, Nobusawa S, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nakazato Y, Tanaka Y, Vital A, Mariani L, Stawski R, Watanabe T, De Girolami U, Kleihues P, Ohgaki H (2010) Molecular classification of low-grade diffuse gliomas. Am J Pathol 177:2708-2714

8. Nobusawa S, Lachuer J, Wierinck A, Kim YH, Huang J, Legras C, Kleihues P, Ohgaki H (2010) Regional patterns of genomic imbalance in glioblastoma. Brain Pathol. 20:936-944

9. Nobusawa S, Watanabe T, Kleihues P, Ohgaki H (2009) IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin. Cancer Res 15:6002-6009

10. Watanabe T, Vital A, Nobusawa S, Kleihues P, Ohgaki H (2009) Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome. Acta Neuropathol. 117:653-656

11. Watanabe T, Nobusawa S, Kleihues P, Ohgaki H (2009) IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am. J. Pathol. 174:1149-1153

12. Ohgaki H, Kita D, Favereaux A, Huang H, Homma T, Dessen P, Weiss WA, Kleihues P, Heppner FL (2006) Brain tumors in S100beta-v-erbB transgenic rats. J. Neuropathol. Exp. Neurol. 65:1111-1117