Who's Who

Lynnette Fernandez-Cuesta


Genetic Cancer Susceptibility Group


Genomics on rare cancers

Academic Degrees

2017HDRCancer GenomicsUniversity Lyon-1LyonFrance
2013PostdocCancer GenomicsMax-Planck Institute and University of CologneCologneGermany
2010PhDMolecular BiologyUniversity Lyon-1LyonFrance
2006MS-2Cancer ResearchUniversidad de OviedoOviedo-AsturiasSpain
2005BSBiochemistryUniversity of OviedoOviedo-AsturiasSpain

Current Research Projects

  • MESOMICS project (PI L Fernandez-Cuesta): Genetic and genomic characterization of malignant pleural mesothelioma (funded by the INCa and LNCC)
    Key people: Dr N Alcala (Postdoc), Ms I Lboukili (Master student); Key collaborators: Dr M Foll (IARC), Prof F Galateau-Salle (CLB), Dr N Girard (Curie Institute), Dr S Boyault (CLB), Prof L Lang-Lazdunski (UK)

  • LungNENomics project (PI L Fernandez-Cuesta): Unveiling the molecular pathways underlying the development of lung neuroendocrine neoplasms (funded by the NIH, LNCC, DCS, and INCa)
    Key people: Ms N Leblay (PhD student), Ms L Mangiante (PhD student), Ms L Moore (PhD student, visitor from Speel's lab), Ms B Hermans (PhD student, visitor from Speel's lab); Key collaborators: Dr M Foll (IARC), Prof S Lantuejoul (CLB), Dr N Girard (Curie Institute), Dr S Boyault (CLB), Dr T Dayton (Hubrecht Institute), Prof EJ Speel (Maastricht University)

  • Alumni
    Ms L Soudade, Mr Theo Giffon, Dr J Derks (visitor from Speel's lab, Maastricht)

Selected Publications

Key publications in 2018: Churg et al. Highlights of the 14th international mesothelioma interest group meeting: Pathologic separation of benign from malignant mesothelial proliferations and histologic/molecular analysis of malignant mesothelioma subtypes. Lung Cancer. /// Rindi et al. A common classification framework for neuroendocrine neoplasms: an IARC–WHO expert consensus proposal. Mod Pathol. /// Fernandez-Cuesta L, Lantuejoul S, Girard N. Small-Cell Cancer of the Lung: Pathology and Genetics. Reference Module in Biomedical Science. Encyclopedia of Cancer, 3rd Edition. /// George*, (...), Fernandez-Cuesta*, and Thomas. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun. /// Derks, (...), and Fernandez-Cuesta. New insights into the molecular characteristics of pulmonary carcinoids and large-cell neuroendocrine carcinomas, and the impact on their clinical management. J Thorac Oncol. /// Derks, (...), Fernandez-Cuesta*, Speel*, and Dingemans*. Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. Clin Cancer Res.

Key publications in 2017: Leblay, (...), Fernandez-Cuesta*, and Brevet. BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas. J Thorac Oncol.

Key publications in 2016: Fernández-Cuesta et al. Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer. EBiomedicine. /// Fernandez-Cuesta and Mckay. Genomic architecture of lung cancers. Curr Opin Oncol.

Key publications in 2015: Fernández-Cuesta et al. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. /// Fernandez-Cuesta and Thomas. Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer. Clin Cancer Res.

Key publications before 2015: Fernandez-Cuesta et al. Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun. 2014 /// Fernandez-Cuesta et al. CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov. 2014 /// CLCGP and NGM. A genomics-based classification of human lung tumors. Sci Transl Med 2013 /// Peifer*, Fernandez-Cuesta* et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 2012

Scientific Societies Membership

European Neuroendocrine Tumor Society (ENET)
International Association for the Study of Lung Cancer (IASLC)
American Association for Cancer Research (AACR)

Prizes, Honours

IASLC Adi Gazdar Lectureship Award - Pathology (2015)