Who's Who

Lynnette Fernandez-Cuesta


Genetic Cancer Susceptibility Group


Cancer Genomics

Academic Degrees

2017HDRCancer GenomicsUniversity Lyon-1LyonFrance
2013PostdocCancer GenomicsMax-Planck Institute and University of CologneCologneGermany
2010PhDMolecular BiologyUniversity Lyon-1LyonFrance
2006MS-2Cancer ResearchUniversidad de OviedoOviedo-AsturiasSpain
2005BSBiochemistryUniversity of OviedoOviedo-AsturiasSpain

Current Research Projects

  • Genetic and genomic characterization of malignant mesothelioma (funded by the INCa and LNCC)
    Dr Nicolas Alcala (Postdoc), Ms Lorraine Soudade (Master 2 student)

  • Genetic and genomic characterization of lung neuroendocrine tumours (funded by the NIH, LNCC, DCS, and INCa)
    Ms Noemie Leblay (PhD student), Ms Lise Mangiante (Master 2 student). Alumni: Mr Theo Giffon, Dr Jules Derks

  • Molecular characterization of neuroendocrine neoplasms of the body

Selected Publications

Key publications in 2018: George*, (...), Fernandez-Cuesta*, and Thomas. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun. In Press /// Derks, (...), and Fernandez-Cuesta. New insights into the molecular characteristics of pulmonary carcinoids and large-cell neuroendocrine carcinomas, and the impact on their clinical management. J Thorac Oncol. /// Derks, (...), Fernandez-Cuesta*, Speel*, and Dingemans*. Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. Clin Cancer Res.

Key publications in 2017: Leblay, (...), Fernandez-Cuesta*, and Brevet. BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas. J Thorac Oncol.

Key publications in 2016: Fernández-Cuesta et al. Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer. EBiomedicine. /// Fernandez-Cuesta and Mckay. Genomic architecture of lung cancers. Curr Opin Oncol.

Key publications in 2015: Fernández-Cuesta et al. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. /// Fernandez-Cuesta and Thomas. Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer. Clin Cancer Res.

Key publications before 2015: Fernandez-Cuesta et al. Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun. 2014 /// Fernandez-Cuesta et al. CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov. 2014 /// CLCGP and NGM. A genomics-based classification of human lung tumors. Sci Transl Med 2013 /// Peifer*, Fernandez-Cuesta* et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 2012

Scientific Societies Membership

American Association for Cancer Research (AACR)
European Neuroendocrine Tumor Society (ENET)
MESOBANK Scientific Committee
International Association for the Study of Lung Cancer (IASLC)

Prizes, Honours

IASLC Adi Gazdar Lectureship Award - Pathology (2015)