Who's Who

Behnoush Abedi-Ardekani

Scientist (Pathologist)

Genetic Cancer Susceptibility Group


Specialty:

Clinical & Surgical Pathologist

Academic Degrees

YearDegreeMajorInstitutionTownCountry
1998Speciality in medicinePathologyUniversity of Medical SciencesTehranIran
1994DoctorateGeneral MedecineUniversity of Medical SciencesTehranIran


Current Research Projects

  • 1. Targeted sequencing of circulating cell-free DNA (cfDNA) of Esophageal squamous cell carcinoma (ESCC) cases in the Golestan Cohort Study (GCS).
    PI; Co-investigators from IARC: Dariush Nesheli, James McKay, Florence le Calvez-Kelm, Paul Brennan. Co-investigators from DDRI: Reza Malekzadeh.

  • 2. Mutographs of cancer: discovering the causes of cancer through mutational signatures.
    Co-investigator; IARC PI: Paul Brennan; Sanger PI: Mike Startton. Plus multidisciplinary research team from GEP group.

  • 3. Genetic and molecular characterization of bronchopulmonary carcinoids.
    Co-investigator; PI: Lynnette Fernandez-Cuesta at GCS group.

  • 4. Genomic analysis of inherited lung cancer: GeniLuc.
    Co-investigator; PI: James McKay, Head of GCS group.

  • 5. ESCCAPE (Esophageal Squamous Cell Carcinoma African Prevention Efforts).
    Contributing; PI: Valerie McCormack at ENV section, Juachim Scholz, and multiple local PI from East Africa.


Selected Publications

1. Anantharaman D, Abedi-Ardekani B, Beachler DC, Gheit T, Olshan AF, Wisniewski K, Wunsch-Filho V, Toporcov TN, Tajara EH, Levi JE, Moyses RA, Boccia S, Cadoni G, Rindi G, Ahrens W, Merletti F, Conway DI, Wright S, Carreira C, Renard H, Chopard P, McKay-Chopin S, Scelo G, Tommasino M, Brennan P, D'Souza G. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. Int J Cancer. 2017. 140(9):1968-1975. PMID: 28108990.

2. Scelo G, Riazalhosseini Y, Greger L, Letourneau L, Gonzàlez-Porta M, Wozniak MB, Bourgey M, Harnden P, Egevad L, Jackson SM, Karimzadeh M, Arseneault M, Lepage P, How-Kit A, Daunay A, Renault V, Blanché H, Tubacher E, Sehmoun J, Viksna J, Celms E, Opmanis M, Zarins A, Vasudev NS, Seywright M, Abedi-Ardekani B, Carreira C, Selby PJ, Cartledge JJ, Byrnes G, Zavadil J, Su J, Holcatova I, Brisuda A, Zaridze D, Moukeria A, Foretova L, Navratilova M, Mates D, Jinga V, Artemov A, Nedoluzhko A, Mazur A, Rastorguev S, Boulygina E, Heath S, Gut M, Bihoreau MT, Lechner D, Foglio M, Gut IG, Skryabin K, Prokhortchouk E, Cambon-Thomsen A, Rung J, Bourque G, Brennan P, Tost J, Banks RE, Brazma A, Lathrop GM. Variation in genomic landscape of clear cell renal cell carcinoma across Europe. Nat Commun. 2014. 5:5135. PMID: 25351205.

3. Abedi-Ardekani B, Dar NA, Mir MM, Zargar SA, Lone MM, Martel-Planche G, Villar S, Mounawar M, Saidi F, Malekzadeh R, Hainaut P. Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia. BMC Cancer. 2012. 12:602. PMID: 23244191.

4. Abedi-Ardekani B, Kamangar F, Sotoudeh M, Villar S, Islami F, Aghcheli K, Nasrollahzadeh D, Taghavi N, Dawsey SM, Abnet CC, Hewitt SM, Fahimi S, Saidi F, Brennan P, Boffetta P, Malekzadeh R, Hainaut P. Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran. PLoS ONE. 2011. 6(12):e29488. PMID: 22216294.

5. Abedi-Ardekani B, Kamangar F, Hewitt SM, Hainaut P, Sotoudeh M, Abnet CC, Taylor PR, Boffetta P, Malekzadeh R, Dawsey SM. Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. Gut. 2010. 59(9):1178-83. PMID: 20584779.

Scientific Societies Membership

Member of the Iranian Medical Council since 1994
Member of the Iranian Society of Pathologists since 1998

Prizes, Honours

Sep.1998: Second top graduate in Iranian Board of Pathology, Tehran (Iran) University of Medical sciences, Tehran, Iran
April 2007: Distinguished achievement award by Social security Organization for 9 years of valuable service in the field of medicine in Social Security Organization, Karaj, Iran
Feb. 2011: Distinguished published article in an international journal with high impact factor, (Abedi-Ardekani B, et al. Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. Gut. 2010 Sep;59(9):1178-83;12th Avicenna Festival, Tehran university of Medical Sciences, Tehran, Iran