Who's Who
Jiri Zavadil
Group Head
Molecular Mechanisms and Biomarkers Group
Specialty:
Molecular biology and genetics, cancer genomics, mechanisms of tumorigenesisAcademic Degrees
| Year | Degree | Major | Institution | Town | Country |
|---|---|---|---|---|---|
| 1998 | PhD | Biomedicine & Molecular Genetics | Charles University | Prague | Czech Republic |
Current Research Projects
- MicroRNAs as biomarkers of early carcinogenesis in urothelial tissues
Collaborators: J Nortier, B Jelakovic; AP Grollman - MicroRNA roles in HPV-associated carcinomas
Collaborators: R Tachezy; M Tommassino - Toxicogenomic aspects of aristolochic acid-associated nephropathy and urinary tract carcinogenesis
Collaborators: AP Grollman, T Rosenquist, K Dickman (model systems), J Nortier, B Jelakovic (clinical samples)
Selected Publications
Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason C, Carroll WL. Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. (2013) NAT GENET, advanced online publication 3 February 2013Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP. Aristolochic acid-associated urothelial carcinoma in Taiwan. (2012) PROC NAT ACAD SCI USA, 109(21):8241-8246
Poliseno L, Haimovic A, Segura MF, Hanniford D, Christos PJ, Wang J, Shapiro R, Pavlick A, Berman RS, Hernando E, Zavadil J, Osman I. Histology specific microRNA alterations in melanoma. (2012) J INVEST DERM, 132(7):1860-1868
Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, Savvulidi F, Kokavec J, Necas E, Berkova A, Obrtlikova P, Karban J, Mraz M, Pospisilova S, Mayer J, Trneny M, Zavadil J, Stopka T. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. (2011) BLOOD, 117(14):3816-3825
Zavadil J, Ye H, Liu Z-J, Wu J-J, Lee P, Hernando E, Soteropoulos P, Toruner G, Wei JJ. Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas. (2010) PLoS ONE. 5(8):e1236
Scientific Societies Membership
AACR - American Society for Cancer ResearchPrizes, Honours
American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.