Who's Who

Jiri Zavadil

Scientist

Molecular Mechanisms and Biomarkers Group


Specialty:

Molecular biology and genetics, cancer genomics, mechanisms of tumorigenesis

Academic Degrees

YearDegreeMajorInstitutionTownCountry
1998PhDBiomedicine & Molecular GeneticsCharles UniversityPragueCzech Republic


Current Research Projects

  • Mutational signatures of environmental and life-style cancer-risk agents
    Collaborators: B Fervers, B Charbotel, S Rozen, LB Alexandrov, MM Stampfer, R Herbert, A Pandiri

  • Toxicogenomics of aristolochic acid-associated nephropathy and carcinogenesis
    Collaborators: AP Grollman, K Dickman, J Nortier, B Jelakovic, M Dai, S Rozen

  • HPV-associated carcinogenesis
    Collaborators: R Tachezy, M Tommasino


Selected Publications

Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. (2015) INT J CANCER. 136(12): 2967-72

Castells X, Karanović S, Ardin M, Tomić K, Xylinas E, Durand G, Villar S, Forey N, Le Calvez-Kelm F, Voegele C, Karlović K, Mišić M, Dittrich D, Dolgalev I, McKay J, Shariat SF, Sidorenko VS, Fernandes A, Heguy A, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J. Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. (2015) CANCER EPIDEMIOL BIOMARKERS PREV. 24(12):1873-81

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J. Modelling mutational landscapes of human cancers in vitro. (2014) SCI REP, 4:4482

Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason C, Carroll WL. Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. (2013) NAT GENET, 45(3):290-4

Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP. Aristolochic acid-associated urothelial carcinoma in Taiwan. (2012) PROC NAT ACAD SCI USA, 109(21):8241-8246

Scientific Societies Membership

EACR - European Association for Cancer Research
AACR - American Society for Cancer Research
EMGS - Environmental Mutagenesis and Genomics Society

Prizes, Honours

American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.

AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.