Who's Who

Jiri Zavadil

Group Head

Molecular Mechanisms and Biomarkers Group


Molecular biology, cancer genomics, mechanisms of tumorigenesis

Academic Degrees

1998PhDBiomedicine & Molecular GeneticsCharles UniversityPragueCzech Republic

Current Research Projects

  • Toxicogenomics of aristolochic acid-associated cancers
    Collaborators: AP Grollman, K Dickman, J Nortier, B Jelakovic, SG Rozen

  • HPV-associated carcinogenesis
    Collaborators: R Tachezy, M Tommasino

  • Mutational signatures of environmental carcinogens
    Collaborators: B Fervers, B Charbotel, SG Rozen, LB Alexandrov, S Balbo, D Phillips, MM Stampfer, R Herbert, FA Beland

Selected Publications

Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG. Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. (2017) GENOME RES. Jul 24. [Epub ahead of print]

Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, Olivier M, Stopka T, Herceg Z, Hollstein M, Zavadil J, Korenjak M. Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. (2017) ONCOGENE. Jul 10. [Epub ahead of print]

Hollstein M, Alexandrov LB, Wild CP, Ardin M, Zavadil J. Base changes in tumour DNA have the power to reveal the causes and evolution of cancer. (2017) ONCOGENE. 36(2):158-67

Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. (2015) INT J CANCER. 136(12): 2967-72

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J. Modelling mutational landscapes of human cancers in vitro. (2014) SCI REP, 4:4482

Scientific Societies Membership

EMGS - Environmental Mutagenesis and Genomics Society
AACR - American Society for Cancer Research
EACR - European Association for Cancer Research

Prizes, Honours

American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.

AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.