Who's Who

Jiri Zavadil

Group Head

Molecular Mechanisms and Biomarkers Group


Molecular biology, cancer genomics, mechanisms of tumorigenesis

Academic Degrees

1998PhDBiomedicine & Molecular GeneticsCharles UniversityPragueCzech Republic

Current Research Projects

  • Mutational signatures of environmental carcinogens
    Collaborators: B Fervers, B Charbotel, SG Rozen, LB Alexandrov, S Balbo, D Phillips, MM Stampfer, R Herbert

  • HPV-associated carcinogenesis
    Collaborators: R Tachezy, M Tommasino

  • Toxicogenomics of aristolochic acid-associated cancers
    Collaborators: AP Grollman, K Dickman, J Nortier, B Jelakovic, SG Rozen

Selected Publications

Hollstein M, Alexandrov LB, Wild CP, Ardin M, Zavadil J. Base changes in tumour DNA have the power to reveal the causes and evolution of cancer. (2017) ONCOGENE. 36(2):158-67

Castells X, Karanović S, Ardin M, Tomić K, Xylinas E, Durand G, Villar S, Forey N, Le Calvez-Kelm F, Voegele C, Karlović K, Mišić M, Dittrich D, Dolgalev I, McKay J, Shariat SF, Sidorenko VS, Fernandes A, Heguy A, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J. Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. (2015) CANCER EPIDEMIOL BIOMARKERS PREV. 24(12):1873-81

Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. (2015) INT J CANCER. 136(12): 2967-72

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J. Modelling mutational landscapes of human cancers in vitro. (2014) SCI REP, 4:4482

Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP. Aristolochic acid-associated urothelial carcinoma in Taiwan. (2012) PROC NAT ACAD SCI USA, 109(21):8241-8246

Scientific Societies Membership

AACR - American Society for Cancer Research
EACR - European Association for Cancer Research
EMGS - Environmental Mutagenesis and Genomics Society

Prizes, Honours

American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.

AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.