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First global estimate of breast cancer incidence in women living with HIV

16/07/2018 – A new study by researchers from the International Agency for Research on Cancer (IARC) estimates for the first time the global and regional burden of breast cancer among women living with HIV. The study, published in the International Journal of Cancer, combined GLOBOCAN estimates of age-specific breast cancer incidence for each country with the corresponding UNAIDS estimates of HIV prevalence. The results showed that in 2012, more than 6000 women with HIV, most of them premenopausal women living in sub-Saharan Africa, were diagnosed with breast cancer. With an increase in breast cancer incidence expected during the next decade, early detection efforts and research into treatments for this specific population are needed.

McCormack V, Febvey-Combes O, Ginsburg O, Dos-Santos-Silva I
Breast cancer in women living with HIV: a first global estimate
Int J Cancer, Published online 11 July 2018;
https://dx.doi.org/10.1002/ijc.31722

Prediction of acute myeloid leukaemia risk in healthy individuals

13/07/2018 – As part of a new study by scientists from the International Agency for Research on Cancer (IARC) and partners, published in Nature, researchers performed deep sequencing of DNA from individuals who later developed acute myeloid leukaemia (AML) and individuals who did not. The results, based on the large European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, showed that individuals who later developed AML had more genetic mutations per sample, higher variant allele frequencies (indicating greater clonal expansion), and enrichment of mutations in specific genes. In the future, these findings could enable earlier detection and monitoring and may help to inform intervention.

Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al.
Prediction of acute myeloid leukaemia risk in healthy individuals
Nature, Published online 9 July 2018;
https://dx.doi.org/10.1038/s41586-018-0317-6

Blood test can help identify the target population to screen for lung cancer

12/07/2018 – A new study by researchers from the International Agency for Research on Cancer (IARC), published today in JAMA Oncology, demonstrates that a blood test measuring four protein biomarkers can improve the identification of individuals who would later develop lung cancer. These biomarkers may help refine the criteria for including current and former smokers in lung cancer screening programmes, using low-dose computed tomography (CT) scans, aimed at reducing deaths from this common cancer.

Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer
Assessment of lung cancer risk on the basis of a biomarker panel of circulating proteins
JAMA Oncol. Published online 12 July 2018;
http://dx.doi.org/10.1001/jamaoncol.2018.2078

IARC Postdoctoral Opportunities - Section/Group: Section of Early Detection and Prevention/Prevention and Implementation Group

11/07/2018 – A postdoctoral opportunity is immediately available for an epidemiologist/medical statistician at the Prevention and Implementation (PRI) Group. PRI coordinates large international studies to evaluate new primary and secondary cancer preventive strategies, with emphasis on the use of new technologies, including molecular markers.
Deadline: 15 August 2018

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Ms Veronique Terrasse, Press Officer.
Tel: +33 4 72 73 83 66
Email: terrassev@iarc.fr

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