Current cancer prevention initiatives for lip, oral cavity, and pharyngeal cancers are limited because of an absence of knowledge on the global incidence of these cancers by site. A new study, conducted by researchers from the International Agency for Research on Cancer (IARC), the American Cancer Society, and the United States National Cancer Institute, outlines and examines, for the first time, the number of new lip, oral cavity, and pharyngeal cancers worldwide by site, sex, and age. The study identifies stark regional variations in these cancers, hypothesized to be due to differences in exposures to carcinogens.
Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, et al.
The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012
CA Cancer J Clin, Published online 19 October 2016; http://dx.doi.org/10.3322/caac.21384
A new large-scale genetic study of head and neck cancers shows why some individuals infected with human papillomavirus (HPV) may go on to develop oropharyngeal cancer while others do not. The study, published today in Nature Genetics, identifies seven new genetic loci (locations of a gene on a chromosome): one that is linked to oropharyngeal cancer and six that are associated with oral cavity cancer, thus providing new insights into the development of these diseases.
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, et al.
Nature Genetics. Published Online 17 October 2016; http://dx.doi.org/10.1038/ng.3685
Read article, Read IARC Press Release 249
17/10/2016 The International Agency for Research on Cancer (IARC) is pleased to announce that Dr Paul Brennan, Head of IARC's Section of Genetics, was today awarded the 2016 Burkitt Medal at the 2016 International Cancer Conference, held at Trinity College Dublin, Ireland. Dr Brennan, who specializes in genetic epidemiology of lung cancer, head and neck cancers, kidney cancer, and lymphomas, presented the Burkitt Lecture, on Cancer Prevention: from Denis Burkitt to the Human Genome Project. Read more
IARC Handbook of Cancer Prevention Volume 15
Breast Cancer Screening
A Working Group of 29 independent experts from 16 countries, convened by the International Agency for Research on Cancer (IARC) in November 2014, reviewed the scientific evidence and assessed the cancer-preventive and adverse effects of various methods of screening for breast cancer. This publication provides an important update of the landmark 2002 IARC Handbook on Breast Cancer Screening, in light of recent improvements in treatment outcomes for late-stage breast cancer and recent data on the effectiveness of organized screening programmes. The Working Group also considered non-mammographic imaging techniques, clinical breast examination, and breast self-examination.