World Cancer Report

World Cancer Report 2014

Edited by Bernard W. Stewart and Christopher P. Wild

ISBN 978-92-832-0429-9


About the cover of World Cancer Report 2014

Circular images (from top to bottom):

  • A woman in The Gambia prepares cereal, using scales to measure portions. Mycotoxins, fungal toxins that can contaminate many cereal crops, have the potential to contribute to cancer in humans. (Credit: C. P. Wild/IARC)

  • Next-generation gene sequencing equipment in use at the Joint Genome Institute in Walnut Creek, California, USA. Large-scale cancer genome studies are already applying next-generation sequencing technologies to tumours from 50 different cancer types to generate more than 25 000 cancer genomes. (Credit: Joint Genome Institute, U.S. Department of Energy Genomic Science Program, accessed at genomicscience.energy.gov)

  • Manhattan plot of pooled genome-wide association study (GWAS) results. The horizontal axis represents chromosome location, and the vertical axis shows -log10 transformed P values, which represent the strength of association. (Credit: Adapted from Purdue MP et al. (2011). Nat Genet, 43: 60-65, Supplementary Figure 2, http://dx.doi.org/10.1038/ng.723. Copyright 2011, with permission from P. Brennan)

  • A group of researchers from the Epigenetics Group in the Section of Mechanisms of Carcinogenesis at IARC. DNA methylation is an epigenetic mark that has important implications for normal gene expression and aberrant gene silencing in cancer. (Credit: R. Dray/IARC)

  • Representative example of high-grade serous carcinoma, one of the main types of ovarian carcinoma. (Credit: J. Prat, Autonomous University of Barcelona)

Background image:

  • The Blue Marble: Next Generation is a mosaic of satellite data taken mostly from a NASA sensor called the Moderate Resolution Imaging Spectroradiometer (MODIS) that flies aboard NASA's Terra and Aqua satellites. (Credit: NASA/Goddard Space Flight Center/Reto Stöckli)