Research Groups

Section of Environment and Radiation

Current Research Topics:

Environmental pollutants and occupational exposures

  • Pesticides and cancer:
    - AGRICOH Research Consortium: Consortium of currently 28 cohort studies of agricultural workers or pesticide applicators and their families, to investigate the risk of cancer and of other diseases related to exposure to pesticides and other prevalent agricultural exposures (http://agricoh.iarc.fr); specific projects in progress include 1) overall cancer incidence and mortality in agricultural cohorts, 2) risk of haematological malignancies in pesticide applicators and farmers (pooled study including France, Norway, and the USA), 3) risk of breast cancer in female pesticide applicators and spouses of farmers (pooled study including France, Norway, and the USA)
    - Testicular cancer: 1) Case-control study of testicular cancer in France (pilot project TESTESPERA completed in 2013, main study TESTIS started in 2014), with development of a contemporary dust measurement-based pesticide exposure metric (SIGEXPO project); 2) Registry-based study in the Nordic countries investigating parental exposures to pesticides and risk of testicular cancer in their offspring (NORDTEST study)
    - Childhood cancer: 1) Parental occupational exposure to pesticides and home pesticide use and the risk of childhood leukaemia in their offspring within the Childhood Leukaemia International Consortium (CLIC); 2) Pooled study (including France, Germany, and the United Kingdom) of parental exposure to pesticides and the risk of brain tumours in their offspring
  • Various occupational carcinogens: SYNERGY lung cancer consortium: Studying lung cancer risk associated with combined occupational exposures and smoking, by pooling case-control studies of lung cancer from 13 countries (http://synergy.iarc.fr); selected carcinogens in main analyses include asbestos, respirable crystalline silica, polycyclic aromatic hydrocarbons (PAHs), chromium, and nickel
  • Asbestos: Occupational exposure to chrysotile in workers in mines and processing facilities in Asbest, Russian Federation (cohort study) (http://asbest-study.iarc.fr)
  • Occupational exposure to loud noise and the risk of vestibular schwannoma (acoustic neuroma); pooled analyses of case-control studies
  • Pilot study on uranium contamination and cancer risk in the West Rand region, South Africa

Lifestyle and cancer

  • Breast cancer research:
    - African Breast Cancer-Disparities in Outcomes (ABC-DO) study: An African multi-country study of the entire journey of a breast cancer patient, to identify determinants and pathways contributing to poor survival (http://abc-do.iarc.fr/)
    - International Pooling Project of Mammographic Density: Individual-level pooled analysis of breast density and its determinants across 20 diverse countries (http://mdpool.iarc.fr)
    - Breast Cancer in Southern Africa: Population-based review of hormone receptor status performed at diagnosis across Southern Africa
  • Oesophageal cancer:
    - Case-control studies and pilot studies in high-incidence areas in Eastern and Southern Africa (Kenya, Tanzania, Ethiopia, Sudan, Malawi, South Africa), on the role of various potential behavioural and environmental risk factors (ESCCAPE study)
    - Pilot study on khat use, tobacco, and other lifestyle factors and oesophageal and other upper digestive tract cancers in Ethiopia
  • Childhood cancer:
    - Global Acute Leukaemia network (GALnet) consortium: Assessing epidemiological, molecular, and clinical characteristics of childhood leukaemia from high- and low-incidence areas around the world (http://galnet.iarc.fr)
    - Social determinants and birth characteristics and their role in the occurrence of and survival after childhood cancer
    - Collaboration in the Childhood Leukaemia International Consortium (CLIC): Pooled analysis of case-control studies on childhood leukaemia investigating the role of various potential lifestyle-related or environmental risk factors
  • Lung cancer risk in migrants (projects in France and the Nordic countries)

Radiation

  • Medical exposure to ionizing radiation: Multinational cohort study (coordination), EPI-CT: Cohort studies of children with computed tomography (CT) examination and follow up for childhood cancer (http://epi-ct.iarc.fr/)
  • Cancer risk related to nuclear accidents or nuclear testing:
    - The Coordination Action CO-CHER (Cooperation on Chernobyl Health Research).
    - Radiation-related disease risk in nuclear facility workers and their offspring and local residents and their offspring: Pooled analyses of cancer risk in people with in utero exposure to ionizing radiation in exposed populations in the Southern Urals, Russian Federation (SOLO project)
    - Assessment of feasibility of setting up a prospective integrated epidemiologic study of cancer risk in residents of areas near the Semipalatinsk nuclear test site in Kazakhstan (SEMI-NUC) (http://semi-nuc.iarc.fr/)
    - Assessment of potential cancer risks related to the Fukushima nuclear accident
  • Extended follow-up of cancer and all-cause mortality among cohorts of nuclear industry workers in France, the United Kingdom, and the USA (INWORKS)
  • Non-ionizing radiation:
    - Prospective study of mobile phone users (international study with ENV coordinating the French component; COSMOS study)
    - Participation in the CEFALO multinational case-control study: Multicentre study of brain tumours in children and adolescents in relation to mobile phone use

Reviewing the carcinogenicity of individual habits and environmental agents

  • European Code against Cancer, 4th Edition: Co-coordination and leading of expert working groups on Tobacco, Radiation and UV, and Environment and Occupation
  • Review of environmental and occupational carcinogens in Qatar

Links to selected former research projects:

  • Evaluation of the health effects of the Chernobyl accident: Agenda for Research on Chernobyl Health (ARCH) (http://arch.iarc.fr/)
  • INTERPHONE, a multinational case-control study : Large multi-centre study of tumours of the brain, acoustic nerve, and parotid gland in relation to radiofrequency radiation emitted by mobile telephones (The Interphone Study) (http://interphone.iarc.fr/)
  • Effectiveness of Tax and Price Policies for Tobacco Control, within the EU-funded PPACTE project (www.ppacte.eu)