Who's Who

Jiri Zavadil

Group Head

Molecular Mechanisms and Biomarkers Group


Specialty:

Molecular biology and genetics, cancer genomics, mechanisms of tumorigenesis

Academic Degrees

YearDegreeMajorInstitutionTownCountry
1998PhDBiomedicine & Molecular GeneticsCharles UniversityPragueCzech Republic


Current Research Projects

  • Toxicogenomic aspects of aristolochic acid-associated nephropathy and urinary tract carcinogenesis
    Collaborators: AP Grollman, T Rosenquist, K Dickman (model systems), J Nortier, B Jelakovic (clinical samples)

  • MicroRNAs as biomarkers of early carcinogenesis in urothelial tissues
    Collaborators: J Nortier, B Jelakovic; AP Grollman

  • MicroRNA roles in HPV-associated carcinomas
    Collaborators: R Tachezy; M Tommassino


Selected Publications

Jelakovic B, Castells X, Tomic K, Ardin M, Karanovic S, and Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. Int J Cancer. Accepted manuscript online: 2014 Nov 17. doi: 10.1002/ijc.29338. [Epub ahead of print] PubMed PMID: 25403517

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J. Modelling mutational landscapes of human cancers in vitro. (2014) SCI REP, 4:4482

Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason C, Carroll WL. Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. (2013) NAT GENET, advanced online publication 3 February 2013

Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP. Aristolochic acid-associated urothelial carcinoma in Taiwan. (2012) PROC NAT ACAD SCI USA, 109(21):8241-8246

Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, Savvulidi F, Kokavec J, Necas E, Berkova A, Obrtlikova P, Karban J, Mraz M, Pospisilova S, Mayer J, Trneny M, Zavadil J, Stopka T. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. (2011) BLOOD, 117(14):3816-3825

Scientific Societies Membership

TEMTIA - EMT (Epithelial-Mesenchymal Transition) International Association
EMGS - Environmental Mutagenesis and Genomics Society
EACR - European Association for Cancer Research
AACR - American Society for Cancer Research

Prizes, Honours

American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.

AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.