IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
VOLUME 105: DIESEL AND GASOLINE ENGINE EXHAUSTS AND SOME NITROARENES
Lyon, France: 5-12 June 2012
An IARC Monograph is not a new study. It is a comprehensive and critical review and evaluation of the published scientific evidence on the carcinogenicity of human exposures. This review includes data on cancer in humans, cancer bioassays, and the mechanisms of carcinogenesis. National health agencies can use this information as scientific support for their actions to prevent exposure to potential carcinogens.
An interdisciplinary Working Group of expert scientists meets at IARC in Lyon, France, for eight days. The Working Group reviews the published studies and evaluates the weight of the evidence that an environmental factor can increase the risk of cancer. After performing and discussing a critical review of the published scientific evidence, the Working Group formulates the evaluations. As a result, each agent is classified into one of five categories.
After evaluating the weight of the evidence that an agent can increase the risk of cancer, the Working Group classifies the agent into one of five categories: Group 1, carcinogenic to humans; Group 2A, probably carcinogenic to humans; Group 2B, possibly carcinogenic to humans; Group 3, not classifiable as to its carcinogenicity to humans; or Group 4, probably not carcinogenic to humans. Since 1971, more than 900 agents have been evaluated, of which more than 400 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.
The evaluations are performed by an independent panel of international experts. Working Group members are selected on the basis of knowledge and experience, as well as absence of real or apparent conflicts of interests. They serve as individual scientists and not representatives of any organization, government, or industry. The interdisciplinary group of expert scientists who formulated this evaluation includes public health and cancer experts from North America, Europe, and Japan.
Strong safeguards are in place to protect against potential conflicts of interest by experts that could influence outcomes. Each potential participant is required to report financial interests, employment and consulting, and individual and institutional research support related to the subject of the meeting. IARC assesses these interests to determine whether there is a conflict that warrants some limitation on participation. Interests related to the subject of the meeting are disclosed to the meeting participants and in the published volume.
Five categories of participants can be present at Monograph meetings. The Working Group of expert scientists performs the critical reviews and develops the evaluations. Invited Specialists are experts who have critical knowledge and experience but have a real or apparent conflict of interests. These experts contribute their knowledge but do not participate in the evaluations. Representatives of national and international health agencies often attend meetings, and Observers with relevant scientific credentials may be admitted to a meeting in limited numbers. Representatives and Observers do not draft any part of a Monograph or participate in the evaluations. The IARC Secretariat consists of scientists who are designated by IARC and who have relevant expertise. They serve as rapporteurs and participate in all discussions.
During the meeting, the Working Group reviews the published studies and evaluates the weight of the evidence that an agent can increase the risk of cancer. The experts meet mostly in subgroups according to type of expertise during the first part of the meeting and in plenary session during the second part of the meeting. The objectives of the meeting are peer review and consensus. In the evaluation, the agent is classified into one of five categories.
About one year before a Monographs meeting, IARC collects relevant biological and epidemiological data from recognized sources of information, including data storage and retrieval systems such as PubMed. Meeting participants who are asked to prepare preliminary working papers for specific sections are expected to supplement the IARC literature searches with their own searches. Before the meeting, these preliminary working papers prepared by meeting participants are distributed to Working Group members and Invited Specialists for review. All eligible studies published or accepted for publication in the scientific literature before the meeting are considered.
The categorization of an agent is a matter of scientific judgment. The strength of the evidence for carcinogenicity from human and experimental animal data is evaluated and classified into one of the following categories: sufficient evidence, limited evidence, inadequate evidence, or evidence suggesting lack of carcinogenicity. In plenary session, the Working Group combines the human and experimental evaluations to evaluate the carcinogenicity of the agent. The strength of the mechanistic data is characterized and can be pivotal when the human data are inconclusive. Finally, the body of evidence is considered as a whole, in order to reach an overall evaluation of the carcinogenicity of the agent to humans.
Yes. In 1989, in Monographs Volume 46, diesel engine exhaust was classified as probably carcinogenic to humans (Group 2A). However, an advisory group that reviews and recommends future priorities for evaluation or re-evaluation by the IARC Monographs Programme has repeatedly recommended diesel engine exhaust as a high priority for re-evaluation since 1998. Also in 1989, gasoline engine exhaust was classified as possibly carcinogenic to humans (Group 2B).
An IARC external advisory group has repeatedly recommended diesel engine exhaust as a high priority for re-evaluation since 1998. However, the advisory group also recommended that IARC wait to conduct the review until new, important human studies of disease were finished and published in the last few years. In March 2012, the U.S. National Cancer Institute stated that heavy exposure to diesel engine exhaust increased risk of death from lung cancer, based on a study of underground miners in the United States.
For about 20 years, diesel engine exhaust has been classified as probably carcinogenic to humans (Group 2A) and gasoline engine exhaust has been classified as possibly carcinogenic to humans (Group 2B). Scientists participating in the new review may reaffirm these evaluations or change how the agents are classified according to carcinogenic risk. The new evaluation will be based on the independent scientific Working Groupâ€™s assessment of all published evidence.
Most human studies of increased cancer risk from exposure to diesel engine exhaust have focused on health effects from occupational exposure, but the general public is also exposed. Railroad workers, truck drivers, and vehicle mechanics are workers with potential exposure to diesel exhaust. The U.S. National Cancer Institute stated in March 2012 that heavy exposure to diesel engine exhaust increased risk of death from lung cancer, based on a study of underground miners in the United States.