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5 May 2020
Colorectal cancer Infections

Burden of anal squamous cell carcinoma, squamous intraepithelial lesions and HPV16 infection in solid organ transplant recipients: a systematic review and meta-analysis

In a new systematic review published in the American Journal of Transplantation, scientists from the International Agency for Research on Cancer (IARC) and partners in Portugal and the United Kingdom describe the burden of anal squamous cell carcinoma, and its surrogates, in recipients of solid organ transplants. The researchers found substantial and consistent evidence of elevated incidence of anal squamous cell carcinoma in recipients of solid organ transplants compared with the general population.

Transplant recipients are living longer with immunosuppressive therapy and therefore have an increased risk of carcinogenic infections and cancer. Anal infection with human papillomavirus (HPV), especially HPV16, is an important etiological factor for anal precancerous lesions and anal squamous cell carcinoma. The scientists showed that solid organ transplant recipients are at high risk of HPV16 infection, anal precancerous lesions, and invasive anal cancer.

Albuquerque A, Stirrup O, Nathan M, Clifford GM
Burden of anal squamous cell carcinoma, squamous intraepithelial lesions and HPV16 infection in solid organ transplant recipients: a systematic review and meta-analysis
Am J Transplant, Published online 28 April 2020;
https://doi.org/10.1111/ajt.15942

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Publication status

Published in section: IARC News

Publication date: 5 May, 2020, 0:07

Direct link: https://www.iarc.who.int/news-events/burden-of-anal-squamous-cell-carcinoma-squamous-intraepithelial-lesions-and-hpv16-infection-in-solid-organ-transplant-recipients-a-systematic-review-and-meta-analysis/

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