A new study published today in the journal Genome Research reports a tumour-specific mutation spectrum introduced into the genome by glycidamide, which is a metabolite of acrylamide. People can commonly be exposed to acrylamide through dietary sources as well as tobacco smoke.
The collaborative study, led by the Molecular Mechanisms and Biomarkers Group at the International Agency for Research on Cancer (IARC), has now established the presence of a distinctive fingerprint of glycidamide-induced changes in the genome.
Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, et al.
Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans
Genome Research, Published online 7 March 2019;