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30 January 2019

HPV and cutaneous squamous cell carcinoma – an emerging issue

A new review article summarizes epidemiological and biological findings that support the existence of a novel model of human papillomavirus (HPV)-mediated carcinogenesis.

The article, by researchers from the International Agency for Research on Cancer (IARC) and partners, was published today in the Journal of Virology.

Appearing as part of the journal’s Gems series, the review examines the role of cutaneous beta HPVs in the development of cutaneous squamous cell carcinoma.

Evidence indicates that beta HPVs, together with ultraviolet (UV) radiation, contribute to the development of cutaneous squamous cell carcinoma, by facilitating the accumulation of UV-induced DNA mutations.

Because beta HPVs are promoters of skin carcinogenesis, they represent a target for skin cancer prevention, especially in high-risk populations.

Rollison DE, Viarisio D, Amorrutu RP, Gheit T, Tommasino M
An emerging issue in oncogenic virology: the role of beta HPV types in development of cutaneous squamous cell carcinoma
J Virol, Published online 30 January 2019;
https://doi.org/10.1128/JVI.01003-18

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