More
In a new article, scientists from the International Agency for Research on Cancer (IARC) and partners describe a novel virus-driven mechanism that converts p53 from a tumour suppressor protein into a pro-proliferative factor. The article was published in the journal PLoS Pathogens.
In the study, the authors dissect a new mechanism driven by cutaneous beta human papillomavirus (HPV) type 38 in altering the function of p53. This may have an important impact in understanding the biology of wild-type p53 in cancer-transformed cells. p53 is a key protein that is altered in all cancer cells. In about half of human cancers, p53 is inactivated through DNA mutation. The other half of cancers harbour a wild-type p53 gene whose tumour suppressor functions are altered by different mechanisms, which are not yet completely understood.
Romero-Medina MC, Venuti A, Melita G, Robitaille A, Ceraolo MG, Pacini L, et al.
Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression
PLoS Pathog, Published online 19 August 2020;
https://doi.org/10.1371/journal.ppat.1008792
WHO Classification of Tumours: Head and Neck Tumours is now available in print format.
Head a...
The International Agency for Research on Cancer (IARC) is saddened by the passing of Professor JÃ...
The International Agency for Research on Cancer (IARC) is hosting the meeting of the Advisory Gro...