27 March 2014
Modelling mutational landscapes of human cancers
A new report by investigators from the International Agency for Research on Cancer (IARC) describes how key aspects of cancer development can be modelled in cultured cells treated with carcinogenic chemicals. This first-of-its-kind study uses innovative genomics and bioinformatics approaches to establish specific mutation fingerprints left in the cellular DNA by carcinogens during cellular immortalization and clonal expansion, two characteristics of cancer development. The study was published today in the Nature Publishing Group’s Scientific Reports.
Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J.
Modelling mutational landscapes of human cancers in vitro. Scientific Reports (NPG). 4:4482; published on 27 March 2014;
DOI:10.1038/srep04482.
Read article
Publication of the WHO Classification of Tumours, 5th Edition, Volume 9: Head and Neck Tumours
WHO Classification of Tumours: Head and Neck Tumours is now available in print format.
Head a...
21.03.2024
Read more
Professor Jürgen Wahrendorf (23 April 1948–15 March 2024)
The International Agency for Research on Cancer (IARC) is saddened by the passing of Professor JÃ...
19.03.2024
Read more
IARC hosts the Advisory Group to Recommend Priorities for the IARC Monographs during 2025–2029
The International Agency for Research on Cancer (IARC) is hosting the meeting of the Advisory Gro...
19.03.2024
Read more