An article about the 2019 update to the Preamble to the IARC Monographs has just been published in the Journal of the National Cancer Institute. This Commentary describes the motivation and methodology for the recent update to the Preamble to the IARC Monographs and highlights the key changes adopted. In addition, the methodology and utility of the hazard identifications provided by the Monographs are communicated more broadly.
The Preamble to the IARC Monographs provides a well-established framework for evidence integration. It also describes the objective and scope of the programme, the scientific principles and procedures used in developing a Monograph, the types of evidence considered, and the scientific criteria that guide the evaluations.
In 2018, IARC convened an Advisory Group to Recommend an Update to the Preamble to the IARC Monographs, with broad expertise across multiple disciplines, to consider progress in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and evidence integration.
The Advisory Group made specific recommendations for revising the Preamble and prepared a report highlighting key deliberations. The Report of the Advisory Group is now available online. In early 2019, IARC considered and accepted these recommendations, and authorized the updated Preamble for immediate use in the Monographs programme.
Samet JM, Chiu WA, Cogliano V, Jinot J, Kriebel D, Lunn RM, et al.
The IARC Monographs: Updated procedures for modern and transparent evidence synthesis in cancer hazard identification
J Natl Cancer Inst, Published online 11 September 2019;