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Section of Evidence Synthesis and Classification

WHO Classification of Tumours Group

Current Research Topics

Fifth edition of the WHO Classification of Tumours series (WHO Blue Books)

PUBLISHED:

 

FUTURE TITLES:

  • Female Genital Tumours
  • Thoracic Tumours
  • Central Nervous System Tumours
  • Paediatric Tumours
  • Urinary and Male Genital Tumours
  • Head and Neck Tumours
  • Endocrine Tumours
  • Haematolymphoid Tumours
  • Skin Tumours
  • Eye and Orbit Tumours
  • Neuroendocrine Tumours
  • Hereditary Tumours

 

Histopathology laboratory

The histopathology laboratory is part of the activities of the WHO Classification of Tumours Group. It is staffed by an expert biomedical scientist, Ms Christine Carreira, and provides histology support to the projects undertaken at IARC by many groups. The laboratory has processing facilities to produce slides from fresh or fixed tissue samples, and handles complex investigations such as immunohistochemistry and in situ hybridization in addition to standard haemotoxylin and eosin (H&E) stains. The recent addition of automated immunohistochemistry and staining machines has increased its capacity substantially. The histopathology laboratory also houses IARC’s digital pathology facility, including high-throughput or high-resolution slide scanning with the Aperio SCN400 and Objective Imaging Glissando instruments, respectively.

Current projects include:

  • Oesophageal Squamous Cell Carcinoma African Prevention Research – ESCCAPE study (ENV) (PI: Dr Valerie McCormack)
  • Causes of Cancer through Studies of Mutational Signatures – Mutographs project (GEP) (PI: Dr Paul Brennan)
  • European Prospective Investigation into Cancer and Nutrition (EPIC) study
  • Breast cancer epigenetics study (EGE) (PI: Dr Zdenko Herceg)
  • Asbestos exposure and ovarian cancer – EVAMOVAIRE study (MMB) (PI: Dr Jiri Zavadil)
  • TERT mutations and urothelial cancer – DIAGURO project (GCS) (PI: Dr Florence Le Calvez-Kelm)
  • Molecular Subtypes of Premenopausal Breast Cancer in Latin American Women – PRECAMA project (PRI) (PI: Dr Sabina Rinaldi)
  • Genomic analysis of inherited lung cancer – GeniLuc project (GCS) (PI: Dr James McKay)
  • Cervical cancer screening and triage techniques in Latin America – ESTAMPA project (PRI) (PI: Dr Rolando Herrero)
  • Whole slide images for the WHO Classification of Tumours Online website (WCT) (PI: Dr Ian Cree)

 

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