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Section of Mechanisms of Carcinogenesis

Epigenetics Group

Previous Publications

All publications 2020-2015

1. Chung, F. F., & Herceg, Z. (2020). The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. Environ Health Perspect. 128(1): 15001. PMID: 31950866 doi: 10.1289/EHP6104

2. Gupta, P., Shahzad, N., Harold, A., Shuda, M., Venuti, A., Romero-Medina, M. C., . . . Tommasino, M. (2020). Merkel Cell Polyomavirus Downregulates N-myc Downstream-Regulated Gene 1, Leading to Cellular Proliferation and Migration. J Virol. 94(3). PMID: 31694959 doi: 10.1128/jvi.00899-19

3. Hii, L. W., Chung, F. F., Soo, J. S., Tan, B. S., Mai, C. W., & Leong, C. O. (2020). Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously. Breast Cancer Res Treat. 179(3): 615-629. PMID: 31784862 doi: 10.1007/s10549-019-05504-5

4. Howe, C. G., Cox, B., Fore, R., Jungius, J., Kvist, T., Lent, S., . . . Breton, C. V. (2020). Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium. Diabetes Care. 43(1): 98-105. PMID: 31601636 doi: 10.2337/dc19-0524

5. Koroknai, V., Szasz, I., Hernandez-Vargas, H., Fernandez-Jimenez, N., Cuenin, C., Herceg, Z., . . . Balazs, M. (2020). DNA hypermethylation is associated with invasive phenotype of malignant melanoma. Exp Dermatol. 29(1): 39-50. PMID: 31602702 doi: 10.1111/exd.14047

6. Merid, S. K., Novoloaca, A., Sharp, G. C., Kupers, L. K., Kho, A. T., Roy, R., . . . Melen, E. (2020). Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Med. 12(1): 25. PMID: 32114984 doi: 10.1186/s13073-020-0716-9

7. Alcala, N., Leblay, N., Gabriel, A. A. G., Mangiante, L., Hervas, D., Giffon, T., . . . Fernandez-Cuesta, L. (2019). Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids. Nat Commun. 10(1): 3407. PMID: 31431620 doi: 10.1038/s41467-019-11276-9

8. Alfano, R., Guida, F., Galobardes, B., Chadeau-Hyam, M., Delpierre, C., Ghantous, A., . . . Plusquin, M. (2019). Socioeconomic position during pregnancy and DNA methylation signatures at three stages across early life: epigenome-wide association studies in the ALSPAC birth cohort. Int J Epidemiol. 48(1): 30-44. PMID: 30590607 doi: 10.1093/ije/dyy259

9. Awada, Z., Nasr, R., Akika, R., Cahais, V., Cuenin, C., Zhivagui, M., . . . Zgheib, N. K. (2019). DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 11(1): 138. PMID: 31601247 doi: 10.1186/s13148-019-0725-y

10. Bodelon, C., Ambatipudi, S., Dugue, P. A., Johansson, A., Sampson, J. N., Hicks, B., . . . Garcia-Closas, M. (2019). Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies. Breast Cancer Res. 21(1): 62. PMID: 31101124 doi: 10.1186/s13058-019-1145-9

11. Fernandez-Jimenez, N., Garcia-Etxebarria, K., Plaza-Izurieta, L., Romero-Garmendia, I., Jauregi-Miguel, A., Legarda, M., . . . Bilbao, J. R. (2019). The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region. Sci Rep. 9(1): 1298. PMID: 30718669 doi: 10.1038/s41598-018-37746-6

12. Gruzieva, O., Xu, C. J., Yousefi, P., Relton, C., Merid, S. K., Breton, C. V., . . . Melen, E. (2019). Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis. Environ Health Perspect. 127(5): 57012. PMID: 31148503 doi: 10.1289/ehp4522

13. Herceg, Z., & Ambatipudi, S. (2019). Smoking-associated DNA methylation changes: no smoke without fire. Epigenomics. 11(10): 1117-1119. PMID: 31339344 doi: 10.2217/epi-2019-0136

14. Jeong, A., Imboden, M., Ghantous, A., Novoloaca, A., Carsin, A. E., Kogevinas, M., . . . Probst-Hensch, N. (2019). DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma. Int J Environ Res Public Health. 16(4). PMID: 30791383 doi: 10.3390/ijerph16040600

15. Johansson, A., Palli, D., Masala, G., Grioni, S., Agnoli, C., Tumino, R., . . . Flanagan, J. M. (2019). Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk. Clin Epigenetics. 11(1): 66. PMID: 31039828 doi: 10.1186/s13148-019-0664-7

16. Josipovic, G., Tadic, V., Klasic, M., Zanki, V., Beceheli, I., Chung, F., . . . Zoldos, V. (2019). Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system. Nucleic Acids Res. 47(18): 9637-9657. PMID: 31410472 doi: 10.1093/nar/gkz709

17. Kupers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., . . . Felix, J. F. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nat Commun. 10(1): 1893. PMID: 31015461 doi: 10.1038/s41467-019-09671-3

18. Looi, C. K., Chung, F. F., Leong, C. O., Wong, S. F., Rosli, R., & Mai, C. W. (2019). Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment. J Exp Clin Cancer Res. 38(1): 162. PMID: 30987642 doi: 10.1186/s13046-019-1153-8

19. Mendy, M., Caboux, E., & Wild, C. P. (2019). Centralization of the IARC Biobank: Combining Multiple Sample Collections into a Common Platform. Biopreserv Biobank. 17(5): 433-443. PMID: 31091138 doi: 10.1089/bio.2018.0036

20. Paltiel, O., Lemeshow, S., Phillips, G. S., Tikellis, G., Linet, M. S., Ponsonby, A. L., . . . Dwyer, T. (2019). The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 144(1): 26-33. PMID: 30098208 doi: 10.1002/ijc.31635

21. Patil, V., Cuenin, C., Chung, F., Aguilera, J. R. R., Fernandez-Jimenez, N., Romero-Garmendia, I., . . . Herceg, Z. (2019). Human mitochondrial DNA is extensively methylated in a non-CpG context. Nucleic Acids Res. 47(19): 10072-10085. PMID: 31665742 doi: 10.1093/nar/gkz762

22. Perrier, F., Viallon, V., Ambatipudi, S., Ghantous, A., Cuenin, C., Hernandez-Vargas, H., . . . Romieu, I. (2019). Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study. Clin Epigenetics. 11(1): 57. PMID: 30940212 doi: 10.1186/s13148-019-0637-x

23. Pez, F., Gifu, P., Degli-Esposti, D., Fares, N., Lopez, A., Lefrancois, L., . . . Caron de Fromentel, C. (2019). In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties. Exp Cell Res. 384(2): 111643. PMID: 31557464 doi: 10.1016/j.yexcr.2019.111643

24. Reimann, B., Janssen, B. G., Alfano, R., Ghantous, A., Espin-Perez, A., de Kok, T. M., . . . Plusquin, M. (2019). The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome. Front Genet. 10: 325. PMID: 31031804 doi: 10.3389/fgene.2019.00325

25. Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C. J., Vives-Usano, M., Rezwan, F. I., . . . London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics. 11(13): 1487-1500. PMID: 31536415 doi: 10.2217/epi-2019-0066

26. Silva, I. R., Ramos, M., Arantes, L., Lengert, A. V. H., Oliveira, M. A., Cury, F. P., . . . Silveira, H. C. S. (2019). Evaluation of DNA Methylation Changes and Micronuclei in Workers Exposed to a Construction Environment. Int J Environ Res Public Health. 16(6). PMID: 30871143 doi: 10.3390/ijerph16060902

27. Vargas-Ayala, R. C., Jay, A., Manara, F., Maroui, M. A., Hernandez-Vargas, H., Diederichs, A., . . . Accardi, R. (2019). Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection. J Virol. 93(13). PMID: 30996097 doi: 10.1128/JVI.00273-19

28. Zhivagui, M., Ng, A. W. T., Ardin, M., Churchwell, M. I., Pandey, M., Renard, C., . . . Zavadil, J. (2019). Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. Genome Res. 29(4): 521-531. PMID: 30846532 doi: 10.1101/gr.242453.118

29. Alfano, R., Herceg, Z., Nawrot, T. S., Chadeau-Hyam, M., Ghantous, A., & Plusquin, M. (2018). The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review). Curr Environ Health Rep. 5(4): 544-578. PMID: 30361985 doi: 10.1007/s40572-018-0218-8

30. Aushev, V. N., Lee, E., Zhu, J., Gopalakrishnan, K., Li, Q., Teitelbaum, S. L., . . . Chen, J. (2018). Novel Predictors of Breast Cancer Survival Derived from miRNA Activity Analysis. Clin Cancer Res. 24(3): 581-591. PMID: 29138345 doi: 10.1158/1078-0432.Ccr-17-0996

31. Barouki, R., Melen, E., Herceg, Z., Beckers, J., Chen, J., Karagas, M., . . . Nohara, K. (2018). Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int. 114: 77-86. PMID: 29499450 doi: 10.1016/j.envint.2018.02.014

32. Brancaccio, R. N., Robitaille, A., Dutta, S., Cuenin, C., Santare, D., Skenders, G., . . . Gheit, T. (2018). Generation of a novel next-generation sequencing-based method for the isolation of new human papillomavirus types. Virology. 520: 1-10. PMID: 29747121 doi: 10.1016/j.virol.2018.04.017

33. Demetriou, C. A., Degli Esposti, D., Fedinick, K. P., Russo, F., Robinson, O., & Vineis, P. (2018). Filling the gap between chemical carcinogenesis and the hallmarks of cancer: A temporal perspective. Eur J Clin Invest. 48(6): 12. PMID: 29604052 doi: 10.1111/eci.12933

34. Felix, J. F., Joubert, B. R., Baccarelli, A. A., Sharp, G. C., Almqvist, C., Annesi-Maesano, I., . . . London, S. J. (2018). Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol. 47(1): 22-23u. PMID: 29025028 doi: 10.1093/ije/dyx190

35. Fiorito, G., Vlaanderen, J., Polidoro, S., Gulliver, J., Galassi, C., Ranzi, A., . . . Naccarati, A. (2018). Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: A prospective study in nonsmokers. Environ Mol Mutagen. 59(3): 234-246. PMID: 29114965 doi: 10.1002/em.22153

36. Ghantous, A., Hernandez-Vargas, H., & Herceg, Z. (2018). DNA Methylation Analysis from Blood Spots: Increasing Yield and Quality for Genome-Wide and Locus-Specific Methylation Analysis. Methods Mol Biol. 1708: 605-619. PMID: 29224166 doi: 10.1007/978-1-4939-7481-8_31

37. Herceg, Z., Ghantous, A., Wild, C. P., Sklias, A., Casati, L., Duthie, S. J., . . . Hernandez-Vargas, H. (2018). Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer. 142(5): 874-882. PMID: 28836271 doi: 10.1002/ijc.31014

38. Jeong, A., Fiorito, G., Keski-Rahkonen, P., Imboden, M., Kiss, A., Robinot, N., . . . Probst-Hensch, N. (2018). Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases. Environ Int. 119: 334-345. PMID: 29990954 doi: 10.1016/j.envint.2018.06.025

39. Mostafavi, N., Vermeulen, R., Ghantous, A., Hoek, G., Probst-Hensch, N., Herceg, Z., . . . Vlaanderen, J. (2018). Acute changes in DNA methylation in relation to 24h personal air pollution exposure measurements: A panel study in four European countries. Environ Int. 120: 11-21. PMID: 30055357 doi: 10.1016/j.envint.2018.07.026

40. Perrier, F., Novoloaca, A., Ambatipudi, S., Baglietto, L., Ghantous, A., Perduca, V., . . . Ferrari, P. (2018). Identifying and correcting epigenetics measurements for systematic sources of variation. Clin Epigenetics. 10: 38. PMID: 29588806 doi: 10.1186/s13148-018-0471-6

41. Plusquin, M., Chadeau-Hyam, M., Ghantous, A., Alfano, R., Bustamante, M., Chatzi, L., . . . Vineis, P. (2018). DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life. Environ Sci Technol. 52(9): 5427-5437. PMID: 29597345 doi: 10.1021/acs.est.7b06447

42. Romero-Garmendia, I., Garcia-Etxebarria, K., Hernandez-Vargas, H., Santin, I., Jauregi-Miguel, A., Plaza-Izurieta, L., . . . Bilbao, J. R. (2018). Transcription Factor Binding Site Enrichment Analysis in Co-Expression Modules in Celiac Disease. Genes (Basel). 9(5). PMID: 29748492 doi: 10.3390/genes9050245

43. Talukdar, F. R., di Pietro, M., Secrier, M., Moehler, M., Goepfert, K., Lima, S. S. C., . . . Herceg, Z. (2018). Molecular landscape of esophageal cancer: implications for early detection and personalized therapy. Ann N Y Acad Sci. 1434(1): 342-359. PMID: 29917250 doi: 10.1111/nyas.13876

44. Tikellis, G., Dwyer, T., Paltiel, O., Phillips, G. S., Lemeshow, S., Golding, J., . . . Linet, M. S. (2018). The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers. Paediatr Perinat Epidemiol. 32(6): 568-583. PMID: 30466188 doi: 10.1111/ppe.12519

45. Uribe, D., Cardona, A., Esposti, D. D., Cros, M. P., Cuenin, C., Herceg, Z., . . . Cortes-Mancera, F. M. (2018). Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines. Ann Hepatol. 17(3): 444-460. PMID: 29735783 doi: 10.5604/01.3001.0011.7389

46. Van Baak, T. E., Coarfa, C., Dugue, P. A., Fiorito, G., Laritsky, E., Baker, M. S., . . . Waterland, R. A. (2018). Epigenetic supersimilarity of monozygotic twin pairs. Genome Biol. 19(1): 2. PMID: 29310692 doi: 10.1186/s13059-017-1374-0

47. Woo, H. D., Fernandez-Jimenez, N., Ghantous, A., Degli Esposti, D., Cuenin, C., Cahais, V., . . . Herceg, Z. (2018). Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes. Int J Cancer. 143(3): 597-609. PMID: 29574700 doi: 10.1002/ijc.31381

48. Ambatipudi, S., Horvath, S., Perrier, F., Cuenin, C., Hernandez-Vargas, H., Le Calvez-Kelm, F., . . . Herceg, Z. (2017). DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. Eur J Cancer. 75: 299-307. PMID: 28259012 doi: 10.1016/j.ejca.2017.01.014

49. Ancey, P. B., Ecsedi, S., Lambert, M. P., Talukdar, F. R., Cros, M. P., Glaise, D., . . . Hernandez-Vargas, H. (2017). TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors. Stem Cell Reports. 9(1): 264-278. PMID: 28648900 doi: 10.1016/j.stemcr.2017.05.023

50. Beltrami, C. M., Dos Reis, M. B., Barros-Filho, M. C., Marchi, F. A., Kuasne, H., Pinto, C. A. L., . . . Rogatto, S. R. (2017). Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas. Clin Epigenetics. 9: 45. PMID: 28469731 doi: 10.1186/s13148-017-0346-2

51. Bisarro Dos Reis, M., Barros-Filho, M. C., Marchi, F. A., Beltrami, C. M., Kuasne, H., Pinto, C. A. L., . . . Rogatto, S. R. (2017). Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 102(11): 4089-4099. PMID: 28938489 doi: 10.1210/jc.2017-00881

52. Col, E., Hoghoughi, N., Dufour, S., Penin, J., Koskas, S., Faure, V., . . . Vourc’h, C. (2017). Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Sci Rep. 7(1): 5418. PMID: 28710461 doi: 10.1038/s41598-017-05343-8

53. Degli Esposti, D., Aushev, V. N., Lee, E., Cros, M. P., Zhu, J., Herceg, Z., . . . Hernandez-Vargas, H. (2017). miR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival. Sci Rep. 7(1): 15966. PMID: 29162888 doi: 10.1038/s41598-017-16226-3

54. Degli Esposti, D., Sklias, A., Lima, S. C., Beghelli-de la Forest Divonne, S., Cahais, V., Fernandez-Jimenez, N., . . . Herceg, Z. (2017). Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas. Genome Med. 9(1): 33. PMID: 28381277 doi: 10.1186/s13073-017-0419-z

55. Fernandez-Jimenez, N., Sklias, A., Ecsedi, S., Cahais, V., Degli-Esposti, D., Jay, A., . . . Herceg, Z. (2017). Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer. Epigenetics. 12(11): 964-972. PMID: 29099283 doi: 10.1080/15592294.2017.1373919

56. Gonzaga, I. M., Soares Lima, S. C., Nicolau, M. C., Nicolau-Neto, P., da Costa, N. M., de Almeida Simao, T., . . . Ribeiro Pinto, L. F. (2017). TFF1 hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells. Clin Epigenetics. 9: 130. PMID: 29296124 doi: 10.1186/s13148-017-0429-0

57. Halaburkova, A., Jendzelovsky, R., Koval, J., Herceg, Z., Fedorocko, P., & Ghantous, A. (2017). Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A. Clin Epigenetics. 9: 62. PMID: 28603560 doi: 10.1186/s13148-017-0359-x

58. Hernandez-Vargas, H., Gruffat, H., Cros, M. P., Diederichs, A., Sirand, C., Vargas-Ayala, R. C., . . . Accardi, R. (2017). Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines. Sci Rep. 7(1): 5852. PMID: 28724958 doi: 10.1038/s41598-017-05713-2

59. Holmila, R., Sklias, A., Muller, D. C., Degli Esposti, D., Guilloreau, P., McKay, J., . . . Nogueira da Costa, A. (2017). Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma. PLoS ONE. 12(3): e0174265. PMID: 28333958 doi: 10.1371/journal.pone.0174265

60. Huskova, H., Ardin, M., Weninger, A., Vargova, K., Barrin, S., Villar, S., . . . Korenjak, M. (2017). Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. Oncogene. 36(43): 6041-6048. PMID: 28692054 doi: 10.1038/onc.2017.215

61. Kettunen, E., Hernandez-Vargas, H., Cros, M. P., Durand, G., Le Calvez-Kelm, F., Stuopelyte, K., . . . Husgafvel-Pursiainen, K. (2017). Asbestos-associated genome-wide DNA methylation changes in lung cancer. Int J Cancer. 141(10): 2014-2029. PMID: 28722770 doi: 10.1002/ijc.30897

62. Lee, H.-S., & Herceg, Z. (2017). Chapter 30 – Nutritional Epigenome and Metabolic Syndrome. In: LEAD, editor.^editors. Handbook of Epigenetics: the New Molecular and Medical Genetics. 2nd ed.: Elsevier Academic Press; pp. 465–475.

63. Mathot, P., Grandin, M., Devailly, G., Souaze, F., Cahais, V., Moran, S., . . . Dante, R. (2017). DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment. Oncogenesis. 6(10): e390. PMID: 29058695 doi: 10.1038/oncsis.2017.88

64. Narvaez, D. M., Groot, H., Diaz, S. M., Palma, R. M., Munoz, N., Cros, M. P., & Hernandez-Vargas, H. (2017). Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury. Heliyon. 3(9): e00400. PMID: 28948237 doi: 10.1016/j.heliyon.2017.e00400

65. Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., . . . Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Hum Mol Genet. 26(20): 4067-4085. PMID: 29016858 doi: 10.1093/hmg/ddx290

66. Vanzan, L., Sklias, A., & Herceg, Z. (2017). Chapter 3 – Mechanisms of Histone Modifications. In: NO, editor.^editors. Handbook of Epigenetics: the New Molecular and Medical Genetics. 2nd ed.: Elsevier Academic Press; pp. 25–46.

67. Vineis, P., Chadeau-Hyam, M., Gmuender, H., Gulliver, J., Herceg, Z., Kleinjans, J., . . . Wild, C. P. (2017). The exposome in practice: Design of the EXPOsOMICS project. Int J Hyg Environ Health. 220(2 Pt A): 142-151. PMID: 27576363 doi: 10.1016/j.ijheh.2016.08.001

68. Ambatipudi, S., Cuenin, C., Hernandez-Vargas, H., Ghantous, A., Le Calvez-Kelm, F., Kaaks, R., . . . Herceg, Z. (2016). Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study. Epigenomics. 8(5): 599-618. PMID: 26864933 doi: 10.2217/epi-2016-0001

69. Ardin, M., Cahais, V., Castells, X., Bouaoun, L., Byrnes, G., Herceg, Z., . . . Olivier, M. (2016). MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes. BMC Bioinformatics. 17: 170. PMID: 27091472 doi: 10.1186/s12859-016-1011-z

70. Esposti, D. D., Hernandez-Vargas, H., Voegele, C., Fernandez-Jimenez, N., Forey, N., Bancel, B., . . . Herceg, Z. (2016). Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing. Oncotarget. 7(22): 31862-31877. PMID: 26887054 doi: 10.18632/oncotarget.7364

71. Grandin, M., Mathot, P., Devailly, G., Bidet, Y., Ghantous, A., Favrot, C., . . . Dante, R. (2016). Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference. EMBO Mol Med. 8(8): 863-877. PMID: 27378792 doi: 10.15252/emmm.201505945

72. Herceg, Z. (2016). Epigenetic Mechanisms as an Interface Between the Environment and Genome. Adv Exp Med Biol. 903: 3-15. PMID: 27343085 doi: 10.1007/978-1-4899-7678-9_1

73. Joehanes, R., Just, A. C., Marioni, R. E., Pilling, L. C., Reynolds, L. M., Mandaviya, P. R., . . . London, S. J. (2016). Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 9(5): 436-447. PMID: 27651444 doi: 10.1161/circgenetics.116.001506

74. Joubert, B. R., Felix, J. F., Yousefi, P., Bakulski, K. M., Just, A. C., Breton, C., . . . London, S. J. (2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 98(4): 680-696. PMID: 27040690 doi: 10.1016/j.ajhg.2016.02.019

75. Showeil, R., Romano, C., Valganon, M., Lambros, M., Trivedi, P., Van Noorden, S., . . . El-Bahrawy, M. (2016). The status of epidermal growth factor receptor in borderline ovarian tumours. Oncotarget. 7(9): 10568-10577. PMID: 26870997 doi: 10.18632/oncotarget.7257

76. Vuong, T., Mallet, J. F., Ouzounova, M., Rahbar, S., Hernandez-Vargas, H., Herceg, Z., & Matar, C. (2016). Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation. J Transl Med. 14(13): 1-12. PMID: 26762586 doi: 10.1186/s12967-016-0770-7

77. Accardi, R., Gruffat, H., Sirand, C., Fusil, F., Gheit, T., Hernandez-Vargas, H., . . . Tommasino, M. (2015). The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models. Carcinogenesis. 36(11): 1440-1451. PMID: 26424750 doi: 10.1093/carcin/bgv142

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