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James Mckay Group Head
Genetic Cancer Susceptibility Group

Speciality: Genetic susceptibility to human diseases, with a particular focus on genetic susceptibilty to tobacco-related cancers
Year Degree Major Institution Country/Town
2003 PhD Molecular Genetics University of Tasmania/IARC Australia/France / Hobart/Lyon
1996 Bsc (first class honors) Molecular Biology University of Tasmania Australia/ / Hobart
Current Research Projects

Genetic susceptibility to lung cancer (INTEGRAL/ILCCO). The aim of this project is characterize the contribution of common genetic variation to lung cancer etiology, smoking behaviour, and joint effects of environmental and genetic interactions on lung cancer risk. We are also exploring how these genetic variants can be combined to identify high risk individuals.and how they can add value to existing lung cancer models.
JD Mckay, C Amos, M Johansson, P Brennan

GENILUC. The goal of this project is to consider the mechanisms by which genetic susceptibility is conveyed. This project studies the somatic tissues of individuals with susceptibility alleles and determines the molecular phenotypes that are present in those individuals.
JD McKay, B Abedi-Ardekani, M Foll

InterLymph DCC. The International Lymphoma Epidemiology Consortium (InterLymph) has been at the forefront of genetic and epidemiological research in lymphomas and multiple myeloma for the last twenty years. We are aiming to develop a data coordinating centre at IARC. This platform, called the Data Coordinating Center (DCC), will ensure that the field’s most pertinent, cutting edge hypothesis driven research questions can be applied within the resources of the InterLymph Consortium.
JD McKay, C Jack, A Clay-Gilmour, Dr H Hjalgrim, Dr L Sucheston-Campbell and Dr S Wang

Nasopharyngeal cancer. NPC remains a significant, but understudied health problem in some of the world’s most populous countries. This project aims to explore the mechanism by which nitrosamines in preserved foods may be influencing the carcinogenic process. It combines genetics, bioinformatics, genomics and cutting edge laboratory techniques to explore how nitrosamines, EBV and genetics work together to influence the carcinogenic process and lead to nasopharyngeal cancer.
L Fernandez Cuesta, R Accardi, J Zavadil, J Fachiroh

Selected Publications

Xuemei J, Mukherjee S, Maria Teresa Landi MT, Bosse Y Philippe Joubert P, Zhu D,…., Shete S, Brenner H, Chanock S, Brennan P, The OncoArray Lung Cancer Consortium, McKay JD, Amos CI Protein-altering germline mutations implicate novel genes related to lung cancer development. Nature Communication Accepted 2020.

Pertesi M, Vallee M, Wei X, Revuelta MV, Galia P, Demangel D, Oliver J, Foll M, Chen S, Perrial E, Garderet L, Corre J, Leleu X, Boyle EM, Decaux O, Rodon P, Kolb B, Slama B, Mineur P, Voog E, Le Bris C, Fontan J, Maigre M, Beaumont M, Azais I, Sobol H, Vignon M, Royer B, Perrot A, Fuzibet JG, Dorvaux V, Anglaret B, Cony-Makhoul P, Berthou C, Desquesnes F, Pegourie B, Leyvraz S, Mosser L, Frenkiel N, Augeul-Meunier K, Leduc I, Leyronnas C, Voillat L, Casassus P, Mathiot C, Cheron N, Paubelle E, Moreau P, Bignon YJ, Joly B, Bourquard P, Caillot D, Naman H, Rigaudeau S, Marit G, Macro M, Lambrecht I, Cliquennois M, Vincent L, Helias P, Avet-Loiseau H, Moreno V, Reis RM, Varkonyi J, Kruszewski M, Vangsted AJ, Jurczyszyn A, Zaucha JM, Sainz J, Krawczyk-Kulis M, Watek M, Pelosini M, Iskierka-Jazdzewska E, Grzasko N, Martinez-Lopez J, Jerez A, Campa D, Buda G, Lesueur F, Dudzinski M, Garcia-Sanz R, Nagler A, Rymko M, Jamroziak K, Butrym A, Canzian F, Obazee O, Nilsson B, Klein RJ, Lipkin SM, McKay JD, Dumontet C. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma. Leukemia. 2019;33(9):2324-30. Epub 2019/04/11. doi: 10.1038/s41375-019-0452-6. PubMed PMID: 30967618; PMCID: PMC6756025.

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeboller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnstrom H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Bruske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindstroem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bosse Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nature genetics. 2017;49(7):1126-32. Epub 2017/06/13. doi: 10.1038/ng.3892. PubMed PMID: 28604730; PMCID: PMC5510465.McKay JD, Hung RJ, Gaborieau V,Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A; EPIC Study, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P (2008) Lung cancer susceptibility locus at 5p15.33. Nat. Genet., 40(12) : 1404-6

Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, Zong X, Laplana M, Wei Y, Han Y, Lloyd A, Delahaye-Sourdeix M, Chubb D, Gaborieau V, Wheeler W, Chatterjee N, Thorleifsson G, Sulem P, Liu G, Kaaks R, Henrion M, Kinnersley B, Vallee M, Le Calvez-Kelm F, Stevens VL, Gapstur SM, Chen WV, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njolstad I, Chen C, Goodman G, Benhamou S, Vooder T, Valk K, Nelis M, Metspalu A, Lener M, Lubinski J, Johansson M, Vineis P, Agudo A, Clavel-Chapelon F, Bueno-de-Mesquita HB, Trichopoulos D, Khaw KT, Johansson M, Weiderpass E, Tjonneland A, Riboli E, Lathrop M, Scelo G, Albanes D, Caporaso NE, Ye Y, Gu J, Wu X, Spitz MR, Dienemann H, Rosenberger A, Su L, Matakidou A, Eisen T, Stefansson K, Risch A, Chanock SJ, Christiani DC, Hung RJ, Brennan P, Landi MT, Houlston RS, Amos CI. Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature genetics. 2017;49(4):651. Epub 2017/03/31. doi: 10.1038/ng0417-651a. PubMed PMID: 28358128.

Delahaye-Sourdeix M, Anantharaman D, Timofeeva MN, Gaborieau V, Chabrier A, Vallee MP, Lagiou P, Holcatova I, Richiardi L, Kjaerheim K, Agudo A, Castellsague X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Mates IN, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wunsch-Filho V, Eluf-Neto J, Boffetta P, Fernandez Garrote L, Polesel J, Lener M, Jaworowska E, Lubinski J, Boccia S, Rajkumar T, Samant TA, Mahimkar MB, Matsuo K, Franceschi S, Byrnes G, Brennan P, McKay JD. A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer. Journal of the National Cancer Institute. 2015;107(5). Epub 2015/04/04. doi: 10.1093/jnci/djv037. PubMed PMID: 25838448; PMCID: PMC4822523.

Cozen W, Timofeeva MN, Li D, Diepstra A, Hazelett D, Delahaye-Sourdeix M, Edlund CK, Franke L, Rostgaard K, Van Den Berg DJ, Cortessis VK, Smedby KE, Glaser SL, Westra HJ, Robison LL, Mack TM, Ghesquieres H, Hwang AE, Nieters A, de Sanjose S, Lightfoot T, Becker N, Maynadie M, Foretova L, Roman E, Benavente Y, Rand KA, Nathwani BN, Glimelius B, Staines A, Boffetta P, Link BK, Kiemeney L, Ansell SM, Bhatia S, Strong LC, Galan P, Vatten L, Habermann TM, Duell EJ, Lake A, Veenstra RN, Visser L, Liu Y, Urayama KY, Montgomery D, Gaborieau V, Weiss LM, Byrnes G, Lathrop M, Cocco P, Best T, Skol AD, Adami HO, Melbye M, Cerhan JR, Gallagher A, Taylor GM, Slager SL, Brennan P, Coetzee GA, Conti DV, Onel K, Jarrett RF, Hjalgrim H, van den Berg A, McKay JD. A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature communications. 2014;5:3856. Epub 2014/06/13. doi: 10.1038/ncomms4856. PubMed PMID: 24920014; PMCID: PMC4055950.

Urayama KY, Jarrett RF, Hjalgrim H, Diepstra A, Kamatani Y, Chabrier A, Gaborieau V, Boland A, Nieters A, Becker N, Foretova L, Benavente Y, Maynadie M, Staines A, Shield L, Lake A, Montgomery D, Taylor M, Smedby KE, Amini RM, Adami HO, Glimelius B, Feenstra B, Nolte IM, Visser L, van Imhoff GW, Lightfoot T, Cocco P, Kiemeney L, Vermeulen SH, Holcatova I, Vatten L, Macfarlane GJ, Thomson P, Conway DI, Benhamou S, Agudo A, Healy CM, Overvad K, Tjonneland A, Melin B, Canzian F, Khaw KT, Travis RC, Peeters PH, Gonzalez CA, Quiros JR, Sanchez MJ, Huerta JM, Ardanaz E, Dorronsoro M, Clavel-Chapelon F, Bueno-de-Mesquita HB, Riboli E, Roman E, Boffetta P, de Sanjose S, Zelenika D, Melbye M, van den Berg A, Lathrop M, Brennan P, McKay JD. Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. Journal of the National Cancer Institute. 2012;104(3):240-53. Epub 2012/01/31. doi: 10.1093/jnci/djr516. PubMed PMID: 22286212; PMCID: PMC3274508.

Scientific Societies Membership

American Association for Cancer Research

American Society of Human Genetics

Prizes, Honours

2005 - CJ Martin fellow
2004 - IARC fellowship, International Agency for Research on Cancer, France
2002 - Winner: Young Tasmanian of the Year: Science and Technology
1999-2001 - Recipient of Special Training Award from International Agency for Research on Cancer, France
1999 - Recipient of the Godard Sapin-Jaloustre Foundation Scholarship for studies in France
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Publication status

Published in section: WHO'S WHO

Publication date: 19 July, 2018, 11:21

Direct link: https://www.iarc.fr/staff_member/james-mckay/

© Copyright International Agency on Research for Cancer 2020