Jiri Zavadil
Deputy Branch Head
Epigenomics and Mechanisms
Speciality: Molecular biology, cancer genomics, mechanisms of tumorigenesis
Year | Degree | Major | Institution | Country/Town |
---|---|---|---|---|
1998 | PhD | Biomedicine & Molecular Genetics | Charles University | Czech Republic / Prague |
Current Research Projects
Experimental toxicogenomics of cancer risk agents
Collaborators: SG Rozen, LB Alexandrov, S Balbo, L Peterson, RJ Turesky, S Hecht, D Phillips, M Stratton, MM Stampfer, R Herbert, FA Beland, D Mandrioli, M Dusinska, L Sancey, B Busser
Molecular cancer epidemiology
Collaborators: B Fervers, B Charbotel, S Deneuve, F Virard, K Smits, L Schouten, S Karanovic, AP Grollman, K Dickman, J Nortier, B Jelakovic, SG Rozen, S De Saeger, M De Boevre, F Chung, L Dossus, Valerie McCormack, J Schuz
Topography of the cancer epigenome
Collaborators: LB Alexandrov, SG Rozen, F Virard, E Mathe, T Stopka, MM Stampfer, Z Herceg
Selected Publications
Das S, Thakur S, Korenjak M, Sidorenko VS, Chung FF, Zavadil J. Aristolochic acid-associated cancers: a public health risk in need of global action. (2022) NAT REV CANCER. 22(10):576-591.
Karanović S, Ardin M, Tang Z, Tomić K, Villar S, Renard C, Venturini E, Lorch AH, Lee DS, Stipančić Ž, Slade N, Vuković Brinar I, Dittrich D, Karlović K, Borovečki F, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J. Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. (2022) INT J CANCER. 150(2):374-386.
Thakur S, Cahais V, Turkova T, Zikmund T, Renard C, Stopka T, Korenjak M, Zavadil J. Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization. (2022) CELLS. 11(5):808.
Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, and Zavadil J, Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. (2019) GENOME RES. 29(4): 521-531.
Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG. Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. (2017) GENOME RES. 27(9): 1475-1486.
Scientific Societies Membership
EMGS - Environmental Mutagenesis and Genomics Society
AACR - American Society for Cancer Research
EACR - European Association for Cancer Research
Prizes, Honours
American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.
AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.