IARC News

Epigenetic signatures of cigarette smoking

23/09/2016 A new study involving almost 16,000 individuals from 16 cohorts, co-authored by researchers from the International Agency for Research on Cancer (IARC), shows that cigarette smoking has a broad impact on genome-wide methylation many years after smoking cessation. DNA methylation is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, and lung and cardiovascular disorders. The study, published in the American Heart Association Rapid Access Journal Report, provides new insights into genes affected by smoking, which could improve understanding of smoking-related diseases. These epigenetic alterations could also serve as sensitive and stable markers of lifetime exposure to tobacco smoke.

Epigenetic signatures of cigarette smoking
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, et al. Circulation: Cardiovascular Genetics Published Online 20 September 2016;
http://dx.doi.org/10.1161/CIRCGENETICS.116.001506
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IARC endorses World Declaration for Cancer Research

22/09/2016 The International Agency for Research on Cancer (IARC) has endorsed the World Declaration for Cancer Research and joined a global movement to promote research in order to improve survival rates and the quality of life of patients with cancer. The initiative, launched today in Madrid by the Spanish Association Against Cancer (AECC) and the AECC Scientific Foundation, is also supported by many other international cancer organizations, including the Union for International Cancer Control (UICC), the European Association for Cancer Research (EACR), the European Society for Medical Oncology (ESMO), the United States National Institutes of Health (NIH), Cancer Research UK (CRUK), the American Society of Clinical Oncology (ASCO), the Dutch Cancer Society (KWF-DCS), and the Italian Association for Cancer Research (AIRC). Read declaration

A global view on cancer incidence and national levels of the human development index

20/09/2016 A new study conducted by researchers from the International Agency for Research on Cancer (IARC) shows a strong positive relationship between overall cancer incidence and the Human Development Index (HDI) level. The report, published in the International Journal of Cancer, assessed cancer incidence for all cancers combined and 27 major types according to national HDI levels. Using GLOBOCAN data for 184 countries, age-standardized incidence rates were assessed by four HDI levels (low, medium, high, and very high).

A global view on cancer incidence and national levels of the human development index
Fidler MM, Soerjomataram I, Bray F
Int J Cancer 139(11):243646 (2016). http://dx.doi.org/10.1002/ijc.30382
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Publications

IARC Handbooks of Cancer Prevention Volume 15: Breast Cancer Screening

01/07/2016 IARC Handbook of Cancer Prevention Volume 15
Breast Cancer Screening

A Working Group of 29 independent experts from 16 countries, convened by the International Agency for Research on Cancer (IARC) in November 2014, reviewed the scientific evidence and assessed the cancer-preventive and adverse effects of various methods of screening for breast cancer. This publication provides an important update of the landmark 2002 IARC Handbook on Breast Cancer Screening, in light of recent improvements in treatment outcomes for late-stage breast cancer and recent data on the effectiveness of organized screening programmes. The Working Group also considered non-mammographic imaging techniques, clinical breast examination, and breast self-examination.
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