Actualité du CIRC

Latest data show a global increase of 13% in childhood cancer incidence over two decades

12/04/2017 An international study coordinated by the International Agency for Research on Cancer (IARC) and published today in The Lancet Oncology shows that in 2001–2010, childhood cancer was 13% more common than in the 1980s, reaching an annual incidence rate of 140 per million children aged 0–14 years worldwide.

Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, Hesseling P, Shin HY, Stiller CA, and the IICC-3 contributors.
International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol. Published online 11 April 2017.
http://dx.doi.org/10.1016/S1470-2045(17)30186-9
Read article, IARC Press Release 251

IARC Monographs Volume 118: Evaluation of welding, welding fumes, and some related chemicals

11/04/2017 A Working Group of 17 scientists from 10 countries met at the International Agency for Research on Cancer (IARC) on 21–28 March 2017 to evaluate the carcinogenicity of welding, molybdenum trioxide, and indium tin oxide. A summary of the evaluations has now been published in The Lancet Oncology. The detailed assessments will be published as Volume 118 of the IARC Monographs.

Guha N, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, et al.
Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide
Lancet Oncol, Published online 10 April 2017;
http://dx.doi.org/10.1016/S1470-2045(17)30255-3
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Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

05/04/2017 Human papillomavirus (HPV) infection is an emerging risk factor associated with head and neck cancer. A new study led by the Epigenetics Group at the International Agency for Research on Cancer (IARC) identified a novel epigenetic signature of HPV infection in head and neck squamous cell carcinomas (HNSCCs). This signature, which is independent of the anatomical site, was shown to be a better predictor of survival compared with HPV status determined by viral gene expression, and thus could be leveraged for improved prediction of survival in HNSCCs.
Degli Esposti D, Sklias A, Lima SC, Beghelli-de la Forest Divonne S, Cahais V, Fernandez-Jimenez N, et al.
Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
Genome Medicine. Published online 5 April 2017
http://dx.doi.org/10.1186/s13073-017-0419-z
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Publications

WHO/IARC Classification of Tumours, 4th Edition, Volume 9: WHO Classification of Head and Neck Tumours

23/01/2017 The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome.
Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors.
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